1.
Parkinsonism Relat Disord
; 79: 88-90, 2020 10.
Article
in English
| MEDLINE
| ID: mdl-32906083
ABSTRACT
Susceptibility to Parkinson's disease (PD) increases more than threefold in first-degree relatives of PD patients. Using a mouse model, we investigated in a proof-of-principle approach whether toxin exposure of F0 affects the F1 generation. We provide first evidence that disturbance of the nigrostriatal pathway can be transferred to the next generation.
Subject(s)
Epigenesis, Genetic/genetics , Genetic Predisposition to Disease/genetics , MPTP Poisoning/genetics , MPTP Poisoning/pathology , Animals , Corpus Striatum/pathology , Disease Models, Animal , Mice , Neural Pathways/pathology , Proof of Concept Study , Substantia Nigra/pathology
2.
Neurology
; 77(16): 1580, 2011 Oct 18.
Article
in English
| MEDLINE
| ID: mdl-22006891
