1.
J Med Chem
; 20(10): 1349-51, 1977 Oct.
Article
in English
| MEDLINE
| ID: mdl-409843
ABSTRACT
A series of 2-benzyloxy and 2-benzylthio analogues of primaquine has been synthesized and evaluated against Plasmodium berghei in the mouse and Plasmodium cynomolgi in the rhesus monkey. 8-Aminoquinoline toxicity, as measured in the Rane mouse screen, was reduced, and these compounds showed significant blood schizonticidal antimalarial activity in mice. In monkeys, significant tissue-schizonticidal activity was observed.
Subject(s)
Antimalarials/chemical synthesis , Primaquine/analogs & derivatives , Animals , Haplorhini , Malaria/drug therapy , Mice , Primaquine/chemical synthesis , Primaquine/pharmacology
2.
J Med Chem
; 17(6): 620-4, 1974 Jun.
Article
in English
| MEDLINE
| ID: mdl-4151456