ABSTRACT
Borderline leprosy patients with a reversal reaction were studied and short-term steroid treatment compared with prolonged steroid treatment using voluntary muscle testing (VMT) to assess the results. Prolonged steroid treatment was shown to be superior to short-term treatment and free of harmful effects. It is concluded that with the described antireaction treatment, permanent nerve damage can be prevented, provided that the reversal reaction is detected in time (within 3-4 months).
Subject(s)
Leprosy/drug therapy , Prednisolone/administration & dosage , Humans , Leprosy/complications , Leprosy/physiopathology , Median Nerve/physiopathology , Neuritis/drug therapy , Neuritis/etiology , Neuritis/physiopathology , Time Factors , Ulnar Nerve/physiopathologySubject(s)
Dapsone/therapeutic use , Leprosy/drug therapy , Dapsone/adverse effects , Humans , Leprosy/immunology , Time FactorsABSTRACT
Four Ethiopian patients with leshmaniasis affecting the nose or the mouth are described. Leishmaniasis affecting these sites is relatively common in Ethiopia; this resembles South American leishmaniasis but probably results from direct extension from skin lesions rather than from metastatic spread of organisms.