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1.
Eur J Cardiothorac Surg ; 62(2)2022 07 11.
Article in English | MEDLINE | ID: mdl-35301524

ABSTRACT

The surgical repair of type A aortic dissection often involves prosthetic proximal aortic and arch reconstruction. Hypothermic circulatory arrest is typically used in these complex surgeries given the required prolonged ischaemia and the associated morbidity and mortality. A novel vascular anastomoses device (Device) has been developed to rapidly connect a native vessel to a polyester graft. This study describes deployment of the Device in the ovine model (n = 3; 6 carotid arteries). Anastamoses were created rapidly, and brain ischaemia time was limited to 6 min in all but one vessel. All vessels remained fully patent with normal blood flow and thrombus-free transitions through 6 months. Results thus suggest that this Device has the potential to reduce anastomosis time versus conventional suturing techniques and thereby reduce hypothermic circulatory arrest time.


Subject(s)
Aortic Aneurysm, Thoracic , Aortic Dissection , Blood Vessel Prosthesis Implantation , Brain Ischemia , Anastomosis, Surgical , Aortic Dissection/surgery , Animals , Aorta/surgery , Aorta, Thoracic/surgery , Aortic Aneurysm, Thoracic/surgery , Blood Vessel Prosthesis Implantation/methods , Humans , Sheep , Treatment Outcome
3.
J Thorac Cardiovasc Surg ; 160(2): 368-369, 2020 08.
Article in English | MEDLINE | ID: mdl-31570224
5.
J Thorac Cardiovasc Surg ; 157(3): e69-e70, 2019 Mar.
Article in English | MEDLINE | ID: mdl-30093150
6.
J Thorac Cardiovasc Surg ; 157(3): 866-867, 2019 Mar.
Article in English | MEDLINE | ID: mdl-30007781
7.
J Thorac Cardiovasc Surg ; 156(6): 2087, 2018 12.
Article in English | MEDLINE | ID: mdl-30086989
9.
J Vasc Surg ; 67(1): 332-342, 2018 01.
Article in English | MEDLINE | ID: mdl-28844469

ABSTRACT

OBJECTIVE: Endovascular repair of the ascending aorta is currently limited to patients at high surgical risk with aortic diseases originating above the sinotubular junction. A number of different endovascular technologies and approaches have been used, although no consensus exists regarding a standardized technique. To better understand real-world endovascular approaches to the ascending aorta, we performed a comprehensive review of the types of endovascular aortic stents and associated vascular access used in repair of the ascending aorta. METHODS: A search of the MEDLINE database was conducted from January 1, 1995, through January 31, 2017, with the search term "ascending aortic stent." Studies involving endovascular stenting in which the primary therapy was confined exclusively to the ascending aorta were included. Studies involving hybrid arch procedures and surgical replacement of the ascending aorta associated with aortic stenting were excluded. The type of aortic stent, underlying aortic disease, and surgical approach were recorded along with outcomes, need for reinterventions, and follow-up. RESULTS: A total of 46 publications that focused on primary endovascular repair of the ascending aorta were identified. Thirteen different aortic stent grafts of various designs were used in 118 total patients. The most commonly used device types were thoracic stents (n = 84 [71.2%]) along with abdominal cuffs (n = 13 [11%]) and custom-made grafts (n = 12 [10.2%]). The most commonly treated aortic disease was type A aortic dissection (n = 59 [50%]), followed by aortic pseudoaneurysm (n = 35 [29.7%]), aortic aneurysm (n = 6 [5.1%]), penetrating atherosclerotic ulcer (n = 5 [4.2%]), and acute aortic rupture (n = 3 [2.5%]). Femoral arterial access was used in 62.7% of patients (n = 74); transapical (n = 17 [14.4%]), carotid (n = 15 [12.7%]), and axillary (n = 8 [6.8%]) approaches were also used. The overall type I endoleak rate was 18.6% (n = 22), with 11 patients (9.3%) requiring reintervention. Other complications included all-cause mortality (n = 18 [15.2%]), conversions to open surgery (n = 4 [3.4%]), and cerebrovascular complications (n = 4 [3.4%]). Aorta-related mortality was 5% (n = 6), and average follow-up was 17.2 months. CONCLUSIONS: Despite the absence of a dedicated aortic stent graft for the ascending aorta, patients with a range of ascending aortic diseases are being successfully treated by endovascular technologies. For optimal outcomes, patient selection is critical to align aortic anatomy with the limited device sizing options, and it should be reserved for patients at high surgical risk.


Subject(s)
Aorta/surgery , Aortic Diseases/surgery , Blood Vessel Prosthesis Implantation/methods , Endovascular Procedures/methods , Postoperative Complications/epidemiology , Aortic Diseases/mortality , Blood Vessel Prosthesis Implantation/adverse effects , Blood Vessel Prosthesis Implantation/instrumentation , Blood Vessel Prosthesis Implantation/standards , Endovascular Procedures/adverse effects , Endovascular Procedures/instrumentation , Endovascular Procedures/standards , Humans , Patient Selection , Postoperative Complications/etiology , Reoperation/statistics & numerical data , Stents/adverse effects , Treatment Outcome
10.
J Card Surg ; 32(5): 296-300, 2017 May.
Article in English | MEDLINE | ID: mdl-28436152

ABSTRACT

PURPOSE: Involvement of qualified specialists with proficiency in endovascular therapies has created flux regarding the role of cardiothoracic surgeons, vascular surgeons, and other catheter-skilled specialists in the management of type B aortic dissections. We used manuscript authorship trends and recent match data in order to study how multi-specialty involvement in treating aortic dissections has changed in the endovascular era. METHODS: A PubMed review of published literature between 1998 and 2015 was performed with "aortic dissection" in the title. Case studies and entries with incomplete author or identifying information were excluded. Author number, specialty affiliation, and treatment focus were recorded. Available residency match data were obtained from the National Resident Matching Program (NRMP). RESULTS: Cardiothoracic surgeons represented 38.5% (10/23) of the authors for papers with an endovascular focus in 1998 compared with 27.7% (59/213) in 2015. Vascular surgeons represented 19.2% (5/23) and 37.1% (79/213) of authors in 1998 and 2015, respectively. Radiologists accounted for 30.4% (7/23) of authorship in 1998 and 8.9% (19/213) in 2015. NRMP match data revealed a 10.6% decrease in thoracic surgery matches from 2004 to 2015, while vascular surgery and interventional radiology increased by 74.7% and 191.1%, respectively. CONCLUSIONS: Endovascular technologies have resulted in significant changes as to which specialties manage complicated type B aortic dissections. Vascular surgeons, with both open and extensive endovascular training are optimally positioned to assume a major role in the care of aortic dissection patients. Continued emphasis on endovascular training and multispecialty collaboration is essential for cardiothoracic surgeons in the endovascular era.


Subject(s)
Aortic Aneurysm/surgery , Aortic Dissection/surgery , Databases, Bibliographic , Endovascular Procedures/education , Internship and Residency , Intersectoral Collaboration , Thoracic Surgery/education , Databases, Bibliographic/statistics & numerical data , Databases, Bibliographic/trends , Endovascular Procedures/trends , Humans , Internship and Residency/statistics & numerical data , Physician's Role , Specialties, Surgical , Workforce
11.
Innovations (Phila) ; 12(2): 140-143, 2017.
Article in English | MEDLINE | ID: mdl-28319480

ABSTRACT

We present the case of a 48-year-old woman with an acute type A aortic dissection that was treated with thoracic endovascular aortic repair at our institution. The patient was found to have a focal type A dissection with pericardial effusion but no tamponade physiology and no involvement of the aortic valve or root. We elected to treat the patient's type A aortic dissection with an endovascular stent because of the patient's favorable anatomy and no evidence of neurologic deficits or signs of distal malperfusion. The patient was successfully treated with an abdominal aortic cuff deployed through the axillary artery. An axillary approach was necessary because of the short length of the delivery sheath preventing a transfemoral delivery. At 2-year follow-up, the patient remains free of complications with computed tomography scan revealing complete false lumen thrombosis and a stable endovascular repair. This report demonstrates a case of acute type A aortic dissection successfully treated using thoracic endovascular aortic repair and illustrates the utility of axillary cannulation for precise deployment of stent grafts in the ascending aorta.


Subject(s)
Aortic Aneurysm, Thoracic/surgery , Aortic Dissection/surgery , Blood Vessel Prosthesis Implantation/methods , Blood Vessel Prosthesis Implantation/instrumentation , Endovascular Procedures/instrumentation , Endovascular Procedures/methods , Female , Humans , Middle Aged , Stents , Treatment Outcome
12.
Thorac Cardiovasc Surg ; 65(5): 423-429, 2017 Aug.
Article in English | MEDLINE | ID: mdl-28110488

ABSTRACT

Background There is a paucity of data on outcomes related to combined heart-lung transplantations (HLTs). Our objective was to identify variables associated with mortality and rejection in HLT. Methods The United Network for Organ Sharing database was reviewed for HLT performed between 1993 and 2008. Long-term survivors (survival > 5 years) were compared with short-term survivors (survival < 5 years). Factors associated with rejection were examined. Risk-adjusted multivariable Cox's proportional hazards regression analysis was performed to examine variables associated with mortality and rejection. Results Multivariable analysis revealed that recipient male gender was associated with mortality at 1 year (hazard ratio [HR]: 1.68, 95% confidence interval [CI]: 1.11-2.54, p = 0.01) and 5 years (HR: 1.41, 95% CI: 1.05-1.89, p = 0.02). Preoperative extracorporeal membrane oxygenation (ECMO) was associated with mortality at 1 year (HR: 7.55, 95% CI: 2.55-22.30, p < 0.01) and 5 years (HR: 3.14, 95% CI: 1.19-8.32, p = 0.02). Preoperative mechanical ventilation (MV) was associated with mortality at 1 year (HR: 3.51, 95% CI: 1.77-6.98, p < 0.01) and at 5 years (HR: 2.70, 95% CI: 1.51-4.85, p < 0.01). Multivariable analysis showed that male gender (HR: 1.78, 95% CI: 1.03-3.09, p = 0.04) and cytomegalovirus (CMV) positivity in the recipient and donor (HR: 3.09, 95% CI: 1.59-6.01, p < 0.01) were associated with rejection. Clinical infection in the donor (HR: 2.05, 95% CI: 1.16-3.61, p = 0.01) was also associated with rejection. Conclusion Survival was affected by recipient male sex and need for preoperative ECMO or MV. Risk factors for rejection included male sex, CMV positivity in the donor and recipient, and donor with clinical infection.


Subject(s)
Graft Rejection/mortality , Heart Transplantation/mortality , Lung Transplantation/mortality , Adult , Chi-Square Distribution , Cytomegalovirus Infections/mortality , Databases, Factual , Female , Graft Rejection/immunology , Heart Transplantation/adverse effects , Humans , Lung Transplantation/adverse effects , Male , Middle Aged , Multivariate Analysis , Proportional Hazards Models , Registries , Retrospective Studies , Risk Factors , Sex Factors , Time Factors , Tissue and Organ Procurement , Treatment Outcome , United States
13.
Innovations (Phila) ; 11(5): 355-359, 2016.
Article in English | MEDLINE | ID: mdl-27607762

ABSTRACT

OBJECTIVE: Aortic occlusion with an endoballoon is a well-established technique to facilitate robotic and minimally invasive mitral valve surgery. Use of the endoballoon has several relative contraindications including ascending aortic dilatation greater than 38 mm in size. We sought to review our experience using the endoballoon in cases of totally endoscopic mitral valve surgery with aortic diameters greater than 38 mm. METHODS: A retrospective review of our single-site database was conducted to identify patients undergoing totally endoscopic mitral valve surgery by a single surgeon using an endoballoon and who had ascending aortic dilation. We defined aortic dilation as greater than 38 mm. Computed tomography was done preoperatively on all patients to evaluate the aortic anatomy as well as iliofemoral access vessels. Femoral artery cannulation was done in a standardized fashion to advance and position the endoballoon, to occlude the ascending aorta, and to deliver cardioplegia. RESULTS: From October 2011 through June 2015, 196 patients underwent totally endoscopic mitral valve surgery using an endoballoon at our institution. Twenty-two patients (11.2%) had ascending aortic diameters greater than 38 mm (range, 38.1-46.6 mm; mean, 40.5 ± 2.5 mm). In these cases, there were no instances of aortic dissection or other injury due to balloon rupture, balloon migration, device movement leading to loss of occlusion, or inability to complete planned surgery due to occlusion failure. CONCLUSIONS: Our experience suggests that it is possible to successfully use endoaortic balloon occlusion in patients with ascending aortic dilation with proper preoperative imaging and planning.


Subject(s)
Aorta/abnormalities , Aortic Diseases/therapy , Balloon Occlusion/methods , Cardiac Surgical Procedures/instrumentation , Heart Valve Diseases/surgery , Mitral Valve/surgery , Robotic Surgical Procedures/methods , Aged , Dilatation, Pathologic , Female , Humans , Male , Middle Aged , Minimally Invasive Surgical Procedures/instrumentation , Postoperative Complications/epidemiology , Retrospective Studies , Treatment Outcome
16.
J Card Surg ; 31(8): 541-3, 2016 Aug.
Article in English | MEDLINE | ID: mdl-27349832

ABSTRACT

As more challenging aortic arch anatomy is being treated using aortic stent-grafts, there is an increased risk for proximal Type I endoleaks at the proximal seal zone or subsequent graft migration. We report a case of an endoanchor-assisted thoracic endovascular aneurysm repair of a patient with an aberrant right subclavian artery (ARSA) and aortic arch aneurysm who developed a proximal Type I endoleak in the aortic arch which was subsequently treated with endoanchors.


Subject(s)
Aorta, Thoracic/surgery , Aortic Aneurysm, Thoracic/surgery , Diverticulum/surgery , Endoleak/surgery , Endovascular Procedures/adverse effects , Stents , Subclavian Artery/abnormalities , Adult , Aorta, Thoracic/diagnostic imaging , Aortic Aneurysm, Thoracic/diagnosis , Blood Vessel Prosthesis/adverse effects , Diverticulum/congenital , Diverticulum/diagnostic imaging , Endoleak/diagnosis , Endoleak/etiology , Humans , Male , Prosthesis Design , Subclavian Artery/diagnostic imaging , Subclavian Artery/surgery , Tomography, X-Ray Computed
17.
Catheter Cardiovasc Interv ; 88(2): 287-93, 2016 Aug.
Article in English | MEDLINE | ID: mdl-27122473

ABSTRACT

BACKGROUND: Tricuspid regurgitation (TR) is an under treated disease. Although surgery for TR remains an effective therapy, many patients are considered to be at a high risk or otherwise inoperable. Caval valve implant (CAVI) offers an alternative to surgery in these patients. Trials assessing the safety and efficacy of caval valve implant are lacking. METHODS: The Heterotopic Implantation Of the Edwards-Sapien XT Transcatheter Valve in the Inferior VEna cava for the treatment of severe Tricuspid Regurgitation (HOVER) trial is an FDA approved, physician initiated, prospective, non-blinded (open label), non-randomized safety and feasibility study to determine the safety and efficacy of the heterotopic implantation of the Edwards-Sapien XT valve in the inferior vena cava for the treatment of severe TR in patients who are at high risk or inoperable. Patients with severe TR in the absence of severe pulmonary hypertension will be recruited. They will be evaluated by a multi-disciplinary team who will agree by consensus that the patients' symptoms are from TR. They will undergo imaging to assess the size of the inferior vena cava (IVC) to determine feasibility of the procedure. If patients meet the inclusion criteria and are free from exclusion criteria, after informed consent they will be eligible for enrollment in the study. A total of 30 patients will be enrolled. The primary objective of the study will be to demonstrate procedural success at 30-days and patient success at 1-year. CONCLUSION: Caval valve implant may present an alternative for patients who are at high risk or inoperable for tricuspid valve surgery (TVS) for TR. © 2016 Wiley Periodicals, Inc.


Subject(s)
Catheterization, Central Venous/instrumentation , Catheterization, Central Venous/methods , Heart Valve Prosthesis Implantation/instrumentation , Heart Valve Prosthesis Implantation/methods , Heart Valve Prosthesis , Tricuspid Valve Insufficiency/therapy , Tricuspid Valve , Vena Cava, Inferior , Catheterization, Central Venous/adverse effects , Clinical Protocols , Feasibility Studies , Heart Valve Prosthesis Implantation/adverse effects , Hemodynamics , Humans , Prospective Studies , Prosthesis Design , Research Design , Severity of Illness Index , Treatment Outcome , Tricuspid Valve/diagnostic imaging , Tricuspid Valve/physiopathology , Tricuspid Valve Insufficiency/diagnostic imaging , Tricuspid Valve Insufficiency/physiopathology , Vena Cava, Inferior/diagnostic imaging , Vena Cava, Inferior/physiopathology
18.
Innovations (Phila) ; 11(3): 217-8, 2016.
Article in English | MEDLINE | ID: mdl-27093272

ABSTRACT

We aimed to develop a method that provides an alternative cannulation site in robotic mitral valve surgery that allows simultaneous endo-occlusion and antegrade perfusion. A 71-year-old man with severe mitral regurgitation and history of coronary artery bypass grafting underwent totally endoscopic robotic mitral valve repair. A 23-mm endoreturn cannula was placed through a 10-mm graft that was sewn to the left axillary artery. An endoballoon was passed through the Dacron/cannula complex and into the ascending aorta. This complex was used for simultaneous antegrade perfusion, endoballoon occlusion, and antegrade cardioplegia. Completion transesophageal echocardiography showed no evidence of mitral regurgitation. The patient had an uneventful postoperative course and was doing well at his 2-month follow-up appointment. The left axillary artery is a viable option for simultaneous endoballoon occlusion, antegrade perfusion, and antegrade cardioplegia in robotic mitral valve surgery. This has the potential benefit of providing antegrade perfusion, which some studies have shown to be associated with a decreased risk of complications when compared with retrograde perfusion specifically in patients with severe peripheral vascular disease.


Subject(s)
Axillary Artery/surgery , Balloon Occlusion/methods , Heart Valve Prosthesis Implantation/methods , Mitral Valve Insufficiency/therapy , Robotic Surgical Procedures/methods , Aged , Combined Modality Therapy , Echocardiography, Transesophageal , Humans , Male , Mitral Valve Insufficiency/diagnostic imaging , Perfusion/methods
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