1.
Bioorg Med Chem Lett
; 22(17): 5595-9, 2012 Sep 01.
Article
in English
| MEDLINE
| ID: mdl-22841436
ABSTRACT
A series of 2-methoxyacylhydrazones were optimized to yield compounds with high affinity for PDE10A. Several compounds demonstrated efficacy in animal models of schizophrenia, including conditioned avoidance response and a pro-psychotic phencyclidine hyperactivity model.