Transgender Attitudes and Beliefs Scale-Spanish (TABS-S) Version: Translation and Initial Evaluation of Psychometric Properties.

Although the field of transprejudice studies has been growing, the literature suggests a need for quality assessments in languages other than English. To address this need, our study translated the Transgender Attitudes and Beliefs Scale (TABS) and evaluated its psychometric properties for use with Spanish-speaking populations. We recruited participants (N = 605) from American and Spanish samples. Results of the confirmatory factor analysis showed adequate fit, confirming the three-factor structure of TABS-Spanish Version (TABS-S). Correlations with existing measures provided evidence for its convergent and discriminant validity. Known-groups validity of the TABS-S was evidenced through confirming previous findings that females show less transgender prejudice than males. Moreover, the internal consistency of the TABS-S scores was high for the total scale (α = .96) and subscales (α = .87-.96). Overall, there is preliminary evidence to suggest that the TABS-S is a valid and reliable scale appropriate for use with Spanish-speaking populations.

Reducción del estigma hacia el trastorno mental en estudiantes de educación social a través de estudios de casos y aprendizaje basado en problemas / Reduction of stigma towards mental disorder in social education students through case studies and problem-based learning

Los trastornos mentales son una de las condiciones más estigmatizadas ennuestra sociedad, lo que supone un obstáculo para la recuperación de estaspersonas. Sin embargo, las actitudes estigmatizantes pueden cambiar, y laeducación y la experiencia personal con personas que tienen un trastorno mentalpueden reducir las actitudes estigmatizantes. El presente estudio evaluó el estigmade 111 estudiantes de educación social hacia las personas con trastornos mentalesy los conocimientos sobre los trastornos mentales antes y después de unaintervención educativa que incluía estudios de casos activos y metodologías deaprendizaje basado en problemas. Se utilizaron autoinformes para medir lasactitudes hacia el trastorno mental y conocimientos sobre salud mental. Lasactitudes negativas hacia los trastornos mentales se redujeron y los conocimientosaumentaron tras la intervención (p< 0,05). Estos resultados demuestran la eficaciade este tipo de intervenciones educativas activas en la reducción del estigma hacialas personas con trastornos mentales. Sin embargo, es importante seguir realizandoestudios de este tipo para aumentar las pruebas científicas

Mental disorders are one of the most stigmatized conditions in our society,which is a barrier to recovery for these individuals. However, stigmatizing attitudescan change, and education and personal experience with people who have amental disorder can reduce stigmatizing attitudes. The present study assessed 111social education students' stigma toward people with mental disorders andknowledge about mental disorders before and after an educational interventioninvolving active case studies and problem-based learning methodologies. Selfreports were used to measure attitudes toward mental disorder and knowledgeabout mental health. Negative attitudes towards mental disorders were reducedand knowledge increased after the intervention (p< .05). These results demonstratethe effectiveness of this type of active educational interventions in reducing stigma towards people with mental disorders. However, it is important to continueconducting studies of this type to increase the scientific evidence. (AU)

Transgender Attitudes and Beliefs Scale (TABS): Validation with a Sample of Self-Identified Christians.

Transgender people suffer from a variety of consequences as victims of anti-transgender prejudice. Christians have been frequently identified as holding negative attitudes toward transgender people; however, there is evidence that these attitudes may be changing. Accurate measurement of attitudes is important in understanding currently held beliefs and to assess potential changes over time. This study tested the validity of the Transgender Attitudes and Beliefs Scale (TABS) for use with the Christian population with a sample of 207 self-identified Christians in the United States. Confirmatory factor analysis (CFA) confirmed the factor structure of TABS: χ2 (374, N = 207) = 821.46, p < 0.001 (normed χ2 = 2.20 < 4); RMSEA = .076 (90%CI = .069; .083), CFI = .926, SRMR = .053. Overall, results suggest that TABS is an appropriate instrument to utilize with the Christian population in the United states.

Improvement in Gender and Transgender Knowledge in University Students Through the Creative Factory Methodology.

In Spain, Social Educators, similar to both social workers and educators in the United States, help coordinate social change through educational interventions and mobilization of social groups to benefit marginalized people and overall societal welfare. They are trained to work with diverse populations, and it is important that they have awareness and training on gender and transgender issues given the extensive discrimination that transgender people endue. Research has begun to identify the important role that knowledge and attitudes of health and educational professionals may play in providing a supportive, healing context to combat the harmful effects of this discrimination and how educational trainings may foster improved knowledge and attitudes in helping professions. This study describes a program to improve knowledge and positive attitudes toward gender and especially transgender people in university students who study Social Education. The researchers measured knowledge and attitudes toward gender and transgender people issues of 64 students before and after receiving a 4-month interactive training. They used the Short Form of the Genderism and Transphobia Scale, a 12-item scale of transphobia and gender ideology variables. The researchers also asked participants about their knowledge of gender and transgender issues before and after training. The methodological experience "Creative Factory" was employed as an interactive training program. The main goal of this methodology is to enable students in a formative context to analyze social realities to generate discussion and innovate ideas to design successful practices. After 4 months of training with a weekly session on gender and transgender learning, students showed improvements in knowledge and attitudes toward both gender and transgender people. Specifically, students demonstrated more knowledge about gender and transgender issues and more positive attitudes toward transgender people. The study demonstrates that training in gender education using the Creative Factory methodology improved knowledge and attitudes in students.

Measuring Discrimination Against Transgender People at the University of the Basque Country and in a Non-University Sample in Spain.

Transgender people suffer from others' negative attitudes in many situations. The university context is one environment where further progress has to be made to ensure the inclusion of transgender people. In this study, a sample of 376 undergraduate students was collected and their attitudes towards transgender people were analyzed. A comparison was made between number of years in university, and a sample from the general public. In addition, comparisons were made by gender, since the literature shows more negative attitudes toward transgender people in men than in women. The results show relatively positive attitudes toward transgender people among higher education students, but they have little knowledge of transgender identity. In turn, researchers found significant differences between different years in the university and between genders. These results support the need to expand knowledge about transgender people in the university environment.

Thyroid Hormone Receptor ß Suppression of RUNX2 Is Mediated by Brahma-Related Gene 1-Dependent Chromatin Remodeling.

Thyroid hormone receptor ß (TRß) suppresses tumor growth through regulation of gene expression, yet the associated TRß-mediated changes in chromatin assembly are not known. The chromatin ATPase brahma-related gene 1 (BRG1; SMARCA4), a key component of chromatin-remodeling complexes, is altered in many cancers, but its role in thyroid tumorigenesis and TRß-mediated gene expression is unknown. We previously identified the oncogene runt-related transcription factor 2 (RUNX2) as a repressive target of TRß. Here, we report differential expression of BRG1 in nonmalignant and malignant thyroid cells concordant with TRß. BRG1 and TRß have similar nuclear distribution patterns and significant colocalization. BRG1 interacts with TRß, and together, they are part of the regulatory complex at the RUNX2 promoter. Loss of BRG1 increases RUNX2 levels, whereas reintroduction of TRß and BRG1 synergistically decreases RUNX2 expression. RUNX2 promoter accessibility corresponded to RUNX2 expression levels. Inhibition of BRG1 activity increased accessibility of the RUNX2 promoter and corresponding expression. Our results reveal a mechanism of TRß repression of oncogenic gene expression: TRß recruitment of BRG1 induces chromatin compaction and diminishes RUNX2 expression. Therefore, BRG1-mediated chromatin remodeling may be obligatory for TRß transcriptional repression and tumor suppressor function in thyroid tumorigenesis.

Development and Validation of the Transgender Attitudes and Beliefs Scale.

In recent years, issues surrounding transgender have garnered media and legal attention, contributing to rapidly shifting views on gender in the U.S. Yet, there is a paucity of data-driven studies on the public's views of transgender identity. This study reports the development and validation of the Transgender Attitudes and Beliefs Scale (TABS). After constructing an initial 96-item pool from consulting experts and existing scales, Phase 1 of the study was launched, involving an exploratory factor analysis of 48 items. The initial factor analysis with 295 participants revealed three factors across 33 items-16 items on interpersonal comfort, 11 on sex/gender beliefs, and 6 on human value. The internal consistency of each factor was high-α = .97 for Factor 1, α = .95 for Factor 2, and α = .94 for Factor 3. A confirmatory factor analysis was conducted in the second phase with an independent sample consisting of 238 participants. The Attitudes Toward Transgender Individual Scale and the Genderism and Transphobia Scale were also included to test for convergent validity, and the Rosenberg Self-Esteem Scale and the short form of the Marlowe-Crowne Social Desirability Scale were utilized to test discriminant validity. Both of the data collection phases employed MTurk, a form of online sampling with increased diversity compared to college student samples and more generalizability to the general U.S. POPULATION: TABS represents an addition to the literature in its ability to capture a more nuanced conceptualization of transgender attitude not found in previous scales.

Thyroid Hormone Receptor-ß (TRß) Mediates Runt-Related Transcription Factor 2 (Runx2) Expression in Thyroid Cancer Cells: A Novel Signaling Pathway in Thyroid Cancer.

Dysregulation of the thyroid hormone receptor (TR)ß is common in human cancers. Restoration of functional TRß delays tumor progression in models of thyroid and breast cancers implicating TRß as a tumor suppressor. Conversely, aberrant expression of the runt-related transcription factor 2 (Runx2) is established in the progression and metastasis of thyroid, breast, and other cancers. Silencing of Runx2 diminishes tumor invasive characteristics. With TRß as a tumor suppressor and Runx2 as a tumor promoter, a compelling question is whether there is a functional relationship between these regulatory factors in thyroid tumorigenesis. Here, we demonstrated that these proteins are reciprocally expressed in normal and malignant thyroid cells; TRß is high in normal cells, and Runx2 is high in malignant cells. T3 induced a time- and concentration-dependent decrease in Runx2 expression. Silencing of TRß by small interfering RNA knockdown resulted in a corresponding increase in Runx2 and Runx2-regulated genes, indicating that TRß levels directly impact Runx2 expression and associated epithelial to mesenchymal transition molecules. TRß specifically bound to 3 putative thyroid hormone-response element motifs within the Runx2-P1 promoter ((-)105/(+)133) as detected by EMSA and chromatin immunoprecipitation. TRß suppressed Runx2 transcriptional activities, thus confirming TRß regulation of Runx2 at functional thyroid hormone-response elements. Significantly, these findings indicate that a ratio of the tumor-suppressor TRß and tumor-promoting Runx2 may reflect tumor aggression and serve as biomarkers in biopsy tissues. The discovery of this TRß-Runx2 signaling supports the emerging role of TRß as a tumor suppressor and reveals a novel pathway for intervention.