ABSTRACT
BACKGROUND: A previous study found that circulating angiopoietin-1 (angpt-1) concentrations were significantly lower in patients who had a recent ischaemic stroke compared to healthy controls. The primary aim of this study was to assess whether serum angpt-1 could be used as a diagnostic test of ischemic stroke in patients presenting to hospital as an emergency. Exploratory analyses investigated the association of proteins functionally related to angpt-1 (angpt-2, Tie-2, matrix metalloproteinase-9 and vascular endothelial growth factors A, C and D) with ischaemic stroke diagnosis. METHODS: Patients presenting to Townsville University Hospital for emergency assessment of stroke-like symptoms were consecutively recruited and provided a blood sample. After assessment by a consultant neurologist, patients were grouped into those who did, or did not have ischaemic stroke. The potential for serum angpt-1 to diagnose ischaemic stroke was assessed using receiver operator characteristic (ROC) curves. Cross-sectional analyses appraised inter-group differences in the serum concentration of other proteins. RESULTS: One-hundred and twenty-six patients presenting to Townsville University Hospital for emergency assessment of stroke-like symptoms were recruited (median time from symptom onset to hospital presentation: 2.6 (inter-quartile range: 1.2-4.6) hours). Serum angpt-1 had poor ability to diagnose ischaemic stroke in analyses using the whole cohort, or in sensitivity analyses (area under the ROC curve 0.51 (95% CI: 0.41-0.62) and 0.52 (95% CI: 0.39-0.64), respectively). No associations of serum angpt-1 concentration with ischaemic stroke severity, symptom duration or aetiology were observed. Serum concentrations of the other assessed proteins did not differ between patient groups. CONCLUSIONS: Serum angpt-1 concentration is unlikely to be useful for emergency diagnosis of ischaemic stroke.
Subject(s)
Brain Ischemia , Ischemic Stroke , Stroke , Humans , Angiopoietin-1/metabolism , Angiopoietin-2/metabolism , Cross-Sectional Studies , Brain Ischemia/diagnosis , Stroke/diagnosis , HospitalsABSTRACT
BACKGROUND: Creutzfeldt-Jacob disease (CJD) is a human prion disease generally characterized by subacute changes in behavior and intellectual function, often followed by ataxia, vision changes, and myoclonus. Ten percent of cases may present atypically, both symptomatically and in respect to initial investigations. METHODS: We report a case of CJD mimicking acute stroke and review all similar cases in the magnetic resonance imaging era reported in English, identified through a PubMed and SCOPUS search. RESULTS: A 68-year-old woman presented with an acute left parietal syndrome, initially referred as a left middle cerebral artery territory stroke. Structural imaging was unremarkable and focal electroencephalogram changes suggested nonconvulsive status epilepticus. Subsequent clinical progression, with the development of cortical high signal on diffusion-weighted imaging and positive 14-3-3 protein in the cerebrospinal fluid, confirmed a diagnosis of CJD. Review of the literature identified 14 further cases mimicking both anterior and posterior stroke syndromes. CONCLUSIONS: CJD develops primarily within a population in whom stroke risk factors are common and represents a rare but important stroke mimic. Negative vascular imaging in elderly patients with apparent acute stroke syndromes should prompt diagnostic review including consideration of prion diseases.
Subject(s)
Cognition Disorders/etiology , Creutzfeldt-Jakob Syndrome/complications , Stroke/etiology , Aged , Brain/diagnostic imaging , Cognition Disorders/diagnostic imaging , Creutzfeldt-Jakob Syndrome/diagnostic imaging , Disease Progression , Electroencephalography , Female , Humans , Magnetic Resonance Imaging , Stroke/diagnostic imagingSubject(s)
Alcohol-Induced Disorders, Nervous System/diagnosis , Brain Diseases, Metabolic/chemically induced , Brain Diseases, Metabolic/diagnosis , Ethanol/analysis , Hepatic Encephalopathy/diagnosis , Magnetic Resonance Spectroscopy/methods , Alcohol-Induced Disorders, Nervous System/metabolism , Alcohol-Induced Disorders, Nervous System/physiopathology , Brain Diseases, Metabolic/physiopathology , Central Nervous System Depressants/adverse effects , Central Nervous System Depressants/analysis , Central Nervous System Depressants/metabolism , Ethanol/adverse effects , Ethanol/metabolism , Glutamine/metabolism , Hepatic Encephalopathy/metabolism , Hepatic Encephalopathy/physiopathology , Humans , Hyperammonemia/diagnosis , Hyperammonemia/metabolism , Hyperammonemia/physiopathology , Magnetic Resonance Spectroscopy/standards , Male , Middle Aged , Predictive Value of TestsABSTRACT
BACKGROUND: The impact of circle of Willis anatomical variation upon the presentation of stroke is probably underrecognized. CASE PRESENTATION: A 63-year-old right-handed woman developed a left hemiparesis and right leg weakness sequentially following a road traffic accident (RTA). Despite initial concern about the possibility of cervical spinal cord injury, the final diagnosis was bilateral artery-to-artery embolic cerebral infarction with dominant right internal carotid artery. CONCLUSION: The case illustrates the complex presentation of stroke as a pseudo-cervical cord lesion and the impact of circle of Willis anatomical variation upon the expression of large vessel cerebrovascular disease.
