Toddlers' interventions toward fair and unfair individuals.

Cooperative societies rely on reward and punishment for norm enforcement. We examined the developmental origin of these interventions in the context of distributive fairness: past research has shown that infants expect resources to be distributed fairly, prefer to interact with fair distributors, and evaluate others based on their fair and unfair resource allocations. In order to determine whether infants would intervene in third-party resource distributions by use of reward and punishment we developed a novel task. Sixteen-month-old infants were taught that one side of a touch screen produces reward (vocal statements expressing praise; giving a cookie), whereas the other side produces punishment when touched (vocal statements expressing admonishment; taking away a cookie). After watching videos in which one actor distributed resources fairly and another actor distributed resources unfairly, participants' screen touches on the reward and punishment panels while the fair and unfair distributors appeared on screen were recorded. Infants touched the reward side significantly more than the punishment side when presented with the fair distributor but touched the screen sides equally when the unfair distributor was shown. Control experiments revealed no evidence of reward or punishment when infants saw food items they liked and disliked, or individuals uninvolved in the resource distribution events. These results provide the earliest evidence that infants are able to spontaneously intervene in socio-moral situations by rewarding positive actions.

Single injection of rapamycin blocks post-food restriction hyperphagia and body-weight regain in rats.

Given the increasing prevalence of and severity of complications associated with obesity, there is great need for treatments resulting in prolonged weight loss. Long-term maintenance of weight loss requires sustained changes in food-intake and energy-expenditure strategies, which are unfortunately often taxing, resulting in a return to predieting weight. Therefore, drug therapies may facilitate greater adherence to a restricted diet and prolong weight loss. One such drug is rapamycin (RAP), a mechanistic target of rapamycin (mTOR) inhibitor. Here, we show that a single injection of RAP dampens the hyperphagic response in calorically restricted rats when they are returned to free feed immediately or 10 days after injection. Moreover, we demonstrate that a single injection of RAP given to calorically restricted rats prevents body-weight regain when animals are returned to free feed either immediately or 10 days after injection. Furthermore, we extend our previous findings that RAP does not produce malaise or illness and show that RAP does not produce any behavioral deficits that may inhibit an animal from eating. Thus, we suggest that mTOR may be a useful target in obesity research, given that its inhibition may decrease the hyperphagic response following caloric restriction. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

Time-dependent effects of rapamycin on consolidation of predator stress-induced hyperarousal.

Previous studies have indicated that rapamycin, a potent inhibitor of the mammalian target of rapamycin (mTOR) pathway, blocks consolidation of shock-induced associative fear memories. Moreover, rapamycin's block of associative fear memories is time-dependent. It is unknown, however, if rapamycin blocks consolidation of predator stress-induced non-associative fear memories. Furthermore, the temporal pattern of mTOR activation following predator stress is unknown. Thus, the goal of the current studies was to determine if rapamycin blocks consolidation of predator stress-induced fear memories and if so, whether rapamycin's effect is time-dependent. Male rats were injected systemically with rapamycin at various time points following predator stress. Predator stress involves an acute, unprotected exposure of a rat to a cat, which causes long-lasting non-associative fear memories manifested as generalized hyperarousal and increased anxiety-like behaviour. We show that rapamycin injected immediately after predator stress blocked consolidation of stress-induced startle. However, rapamycin injected 9, 24 or 48h post predator stress potentiated stress-induced startle. Consistent with shock-induced associative fear memories, we show that mTOR signalling is essential for consolidation of predator stress-induced hyperarousal. However, unlike shock-induced fear memories, a second, persistent, late phase mTOR-dependent process following predator stress actually dampens startle. Consistent with previous findings, our data support the potential role for rapamycin in treatment of stress related disorders such as posttraumatic stress disorder. However, our data suggest timing of rapamycin administration is critical.