Subject(s)
Clobetasol/adverse effects , Cushing Syndrome/chemically induced , Glucocorticoids/adverse effects , Lichen Planus, Oral/drug therapy , Administration, Topical , Aged , Clobetasol/therapeutic use , Cushing Syndrome/diagnosis , Dose-Response Relationship, Drug , Drug Administration Schedule , Female , Follow-Up Studies , Gels , Glucocorticoids/therapeutic use , Humans , Lichen Planus, Oral/diagnosis , Mouth Mucosa/drug effects , Risk AssessmentABSTRACT
Although methotrexate (MTX) is used in several medical specialties including dermatology, rheumatology, and oncology, drug-induced mucocutaneous ulcerations rarely are reported. We present a 36-year-old woman with plaque psoriasis and psoriatic arthritis being treated with oral MTX (12.5 mg weekly) and oral methoxsalen plus UVA. Following an increase in MTX dose, she developed erosions and ulcerations on her oral mucosa and within her psoriatic plaques. All erosions and ulcerations healed within 2 weeks upon discontinuation of MTX.
Subject(s)
Folic Acid Antagonists/adverse effects , Methotrexate/adverse effects , Oral Ulcer/chemically induced , Psoriasis/pathology , Skin Ulcer/chemically induced , Administration, Oral , Adult , Drug Interactions , Female , Folic Acid Antagonists/administration & dosage , Humans , Methotrexate/administration & dosage , Mouth Mucosa/pathology , Oral Ulcer/pathology , Psoriasis/drug therapy , Skin/pathology , Skin Ulcer/pathologyABSTRACT
We report a case of bismuth-induced pityriasis rosea-like drug eruption. Although historical accounts of bismuth hypersensitivity exist, contemporary reports are lacking. Given the frequency of bismuth administration, a modern review of this phenomenon would seem prudent.
