Subject(s)
Amikacin/administration & dosage , Gentamicins/administration & dosage , Respiratory Tract Infections/drug therapy , Urinary Tract Infections/drug therapy , Adolescent , Amikacin/blood , Child , Child, Preschool , Gentamicins/blood , Humans , Infant , Respiratory Tract Infections/blood , Urinary Tract Infections/bloodSubject(s)
Drug Therapy , Monitoring, Physiologic , Pharmaceutical Preparations/metabolism , Half-Life , Humans , KineticsABSTRACT
The pharmacokinetics of acetylsalicylic acid have been examined in a dose of 3.6 g per day (0.9 g every 6 h) for 4 days, and the effect of the drug in 25 gravidae, threatened by premature delivery, has also been studied. Salicylate in maternal blood was higher than in amniotic fluid, umbilical cord and foetus at birth. It is concluded that 9 h after a dose of 3.6 g acetylsalicylic acid, the salicylate level in maternal blood was sufficient to reduce the number of uterine spasms in most patients. No effect of the drug on blood coagulation in mother or child was observed.
Subject(s)
Aspirin/metabolism , Obstetric Labor, Premature/prevention & control , Amniotic Fluid/metabolism , Aspirin/therapeutic use , Female , Fetal Blood/metabolism , Humans , Infant, Newborn , Kinetics , Placenta/metabolism , Pregnancy , Salicylates/urine , Salicylic Acid , Time FactorsSubject(s)
Intestinal Absorption , Opipramol/metabolism , Administration, Oral , Adult , Biological Availability , Female , Humans , Male , Opipramol/administration & dosage , Solutions , TabletsSubject(s)
Diazepam/metabolism , Administration, Oral , Adult , Diazepam/administration & dosage , Female , Humans , Injections, Intramuscular , Injections, Intravenous , Kinetics , Male , Middle AgedABSTRACT
The relationship between the serum concentration and some of pharmacokinetic parameters of chlorpropamide and the hypoglycemic effect of this drug was studied. Studies were carried out in a group of 18 patients in whom the concentrations of drug and sugar in blood were determined simultaneously. Close correlation between the concentration and some pharmacokinetic parameters of chlorpropamide and the intensity of decrease of the blood glucose level as well as the time of its occurrence has been found.
Subject(s)
Blood Glucose/analysis , Chlorpropamide/pharmacology , Diabetes Mellitus/drug therapy , Adult , Chlorpropamide/blood , Chlorpropamide/therapeutic use , Diabetes Mellitus/blood , Female , Humans , Kinetics , Male , Middle AgedABSTRACT
We determined the relative bioavailability in men of two preparations containing ferrous salts in the form of long-action tablets in relation to analogous conventional preparations in the from of drops and tablets. The comparison of the bioavailability of preparations slowly and quickly releasing the active substance did not show any prolonged effect and greater absorption of drugs slowly releasing the active substance along the alimentary tract.
Subject(s)
Ferrous Compounds/metabolism , Iron/metabolism , Biological Availability , Delayed-Action Preparations , Ferrous Compounds/administration & dosage , Humans , Iron/blood , Kinetics , TabletsABSTRACT
The purpose of this study was to investigate the pharmacokinetics of carbamazepine at steady state, after multiple doses in patients with elevated serum cholesterol levels. Twelve patients participated in the investigation; patients were divided into two groups according to their total serum cholesterol levels. Each patient received multiple doses of carbamazepine 600 mg po once per day. Blood samples were collected and analyzed for carbamazepine by gas-liquid chromatography. The clearance concept was used to describe the pharmacokinetic behavior of carbamazepine in high and low cholesterol patients. The area under the plasma concentration-time curve was determined by the trapezoidal rule method. This value was used to determine the oral dose clearance. In this study, the authors found that the elevated serum cholesterol and elevated total lipids cause a decrease in drug concentration. The significantly higher values of the total body clearance of carbamazepine, obtained in patients with elevated serum cholesterol levels, may have significance in clinical practice.
