Motion loss after ligament injuries to the knee. Part II: prevention and treatment.

This is the second part of a two-part review on motion problems after ligament injuries to the knee. The first part, published in the September/October 2001 issue, discussed normal and abnormal knee motion, terminology, risk factors, and pathoanatomy. The purpose of this article is to review current concepts on prevention and treatment of motion problems, summarizing the recent and pertinent studies that discuss this complicated clinical problem. The first part of this article will discuss the different classification schemes that have been published on motion loss of the knee. Prevention strategies will be discussed next, followed by early recognition. Finally, a discussion of the various treatment options and published results will be presented in detail, together with the authors' nine-step systematic surgical approach to the stiff knee.

Reliability, validity, and responsiveness of four knee outcome scales for athletic patients.

BACKGROUND: Many patient-based knee-rating scales are available for the evaluation of athletic patients. However, there is little information on the measurement properties of these instruments and therefore no evidence to support the use of one questionnaire rather than another. The goal of the present study was to determine the reliability, validity, and responsiveness of four knee-rating scales commonly used for the evaluation of athletic patients: the Lysholm scale, the subjective components of the Cincinnati knee-rating system, the American Academy of Orthopaedic Surgeons sports knee-rating scale, and the Activities of Daily Living scale of the Knee Outcome Survey. METHODS: All patients in the study had a disorder of the knee and were active in sports (a Tegner score of 4 points). Forty-one patients who had a knee disorder that had stabilized and who were not receiving treatment were administered all four questionnaires at baseline and again at a mean of 5.2 days (range, two to fourteen days) later to test reliability. Forty-two patients were administered the scales at baseline and at a minimum of three months after treatment to test responsiveness. The responses of 133 patients at baseline were studied to test construct validity. RESULTS: The reliability was high for all scales, with the intraclass correlation coefficient ranging from 0.88 to 0.95. As for construct validity, the correlations among the knee scales ranged from 0.70 to 0.85 and those between the knee scales and the physical component scale of the Short Form-36 (SF-36) and the patient and clinician severity ratings ranged from 0.59 to 0.77. Responsiveness, measured with the standardized response mean, ranged from 0.8 for the Cincinnati knee-rating system to 1.1 for the Activities of Daily Living scale. CONCLUSIONS: All four scales satisfied our criteria for reliability, validity, and responsiveness, and all are acceptable for use in clinical research.

Motion loss after ligament injuries to the knee. Part I: causes.

Motion loss continues to be a difficult complication after ligament injury and surgery to the knee. A better understanding of the pathoanatomic causes of motion loss can lead to improved prevention and treatment strategies. When motion loss does occur, early recognition and appropriate treatment can be expected to restore motion and improve function in most patients. Treatment options, although varied, should improve outcome when implemented appropriately. This article is composed of two parts. The first part reviews the current concepts on definitions, incidence, and causes of motion loss. In the second part, to be published later, current strategies on prevention and treatment of motion loss after ligament injury to the knee are reviewed. Emphasis is placed on risk factors and prevention as well as on diagnosis and treatment. The article summarizes the latest information from the basic sciences as well as clinical studies on the problem of motion loss of the knee and attempts to provide a rational approach to these difficult clinical problems.

Patients' expectations of knee surgery.

BACKGROUND: Patients' expectations of medical care are linked to their requests for treatment and to their assessments of outcome and satisfaction. Our goals were to measure patients" preoperative expectations of knee surgery and to develop and test patient-derived knee expectations surveys. METHODS: An initial sample of 377 patients (mean age, 54.6 18.2 years; 52% women) was enrolled in the survey-development phase. One hundred and sixty-one (43%) of these patients subsequently underwent total knee arthroplasty; seventy-five (20%), cruciate ligament repair; eighty-five (23%), meniscal surgery; and fifty-six (15%), surgery for another knee condition. Preoperatively, these patients were asked open-ended questions about their expectations of knee surgery. Their responses were grouped with use of qualitative research techniques to generate categories of expectations. Categories were transformed into specific questions and were formatted into two draft surveys, one for patients undergoing total knee arthroplasty and one for patients undergoing other surgical procedures on the knee. A second sample of 163 patients (mean age, 55.1 17.5 years; 49% women) was enrolled in the survey-testing phase, and they completed the draft surveys on two separate occasions to establish test-retest reliability. Items were selected for the final surveys if they were cited by 5% of the patients, if they represented important functional changes resulting from surgery, or if they represented potentially unrealistic expectations. All selected items fulfilled reliability criteria, defined as a kappa (or weighted kappa) value of 0.4, or were deemed to be clinically relevant by a panel of orthopaedic surgeons. RESULTS: From the survey-development phase, a total of fifty-two categories of expectations were discerned; they included both anticipated items such as pain relief and improvement in walking ability and unanticipated items such as improving psychological well-being. Expectations varied by diagnosis and patient characteristics, including functional status. Two final surveys were generated: the seventeen-item Hospital for Special Surgery Knee Replacement Expectations Survey and the twenty-item Hospital for Special Surgery Knee Surgery Expectations Survey. Each required less than five minutes to complete. CONCLUSIONS: Patients have multiple expectations of knee surgery in the areas of symptom relief and improvement of physical and psychosocial function, and these expectations vary according to the diagnosis. We developed two valid and reliable surveys that can be used preoperatively to direct patient education and shared decision-making and to provide a framework for setting reasonable goals. Reexamining patients' responses postoperatively could provide a way to assess fulfillment of expectations, which is a crucial patient-derived measure of outcome and satisfaction.

Development and evaluation of an activity rating scale for disorders of the knee.

Reports of clinical studies of patients with knee disorders should routinely include their activity levels to enable comparison of treatment groups and to allow generalizability. The goal of this study was to develop and evaluate a new rating scale to measure activity levels of patients. We assessed reliability by administering the scale to 40 subjects on 2 separate occasions, 1 week apart. Validity was evaluated by comparing the activity rating on the new scale with that from other instruments that use activity level scales (concurrent construct validity) and also by correlating the score on the new scale with age (divergent validity). Patients easily understood the scale and were able to complete it in 1 minute. The reliability was high (intraclass correlation coefficient, 0.97). The scale also correlated well with existing activity rating scales: Spearman correlation coefficient for Cincinnati score, 0.67; for Tegner scale, 0.66; for Daniel scale, 0.52. The activity score was significantly inversely correlated with age (P = 0.002), indicating divergent validity. This instrument will facilitate generalizability of results and allow more accurate comparisons among patient groups in outcomes research in sports medicine.

Development of the popliteomeniscal fasciculi in the fetal human knee joint.

PURPOSE: The purpose of this study is to better understand the function of the popliteomeniscal fasciculi and their relationship to the popliteus tendon and the lateral meniscus by describing these structures during embryonic development. TYPE OF STUDY: Anatomic dissection and histologic evaluation. METHODS: Twelve fresh-frozen lower extremity specimens (6 paired limbs) from second and third trimester human fetuses were obtained from spontaneous abortions. Each specimen was fixed in formalin and decalcified in 9.0% nitric oxide. The specimens were prepared by removal of all skin and most of the soft tissues before dissection of the lateral meniscus, parts of the posterolateral joint capsule, and the popliteus tendon and muscle. The right-side specimens were sectioned in the transverse plane, and the left-side specimens in the coronal plane. Histologic sections were prepared with H&E and Masson's trichrome stains. Light microscopy was used to evaluate the lateral meniscal attachment, with detailed attention to the popliteomeniscal fasciculi. RESULTS: The close interrelationship of lateral meniscus and popliteus tendon, especially during embryologic development, does give a better understanding how the fasciculi stabilize the lateral meniscus and allow the popliteus tendon to function as a retractor of the lateral meniscus. The fasciculi consist of 3 layers including a dense collagen layer, a vascular layer, and a synovial or capsular layer. CONCLUSIONS: During embryologic development, the fasciculi appeared to provide a vascular supply to the lateral meniscus adjacent to the popliteal hiatus where the meniscus is devoid of capsular attachments.

Meniscal tears in the athlete. Operative and nonoperative management.

There are many factors to consider when treating an active individual with a known or suspected meniscal tear. The athlete with a meniscal tear sometimes can return to competition, temporarily delaying surgery until after the season. If an athlete remains symptomatic and is unable to return, however, then arthroscopic surgery generally is effective to allow the athlete to resume participation. The decision of meniscal repair versus excision must be carefully thought out and discussed with the athlete before surgery. Either treatment can allow the athlete to return to their sport. It is controversial whether or not an athlete should be allowed early return to play after meniscal repair. Further prospective randomized studies would provide useful information in deciding which type of treatment and which type of rehabilitation is best suited for the active individual.

Management of unicompartmental arthritis in the anterior cruciate ligament-deficient knee.

There exists a group of patients who are difficult to manage because they have both anterior knee instability secondary to anterior cruciate ligament deficiency and unilateral degenerative joint disease. A large majority of these patients report a history of previous meniscal injury or meniscectomy after knee trauma at a relatively young age. Active patients who report symptomatic knee instability or pain associated with athletics or activities of daily living after conservative treatment may be indicated for surgery. Current endoscopic methods of anterior cruciate ligament reconstruction result in low patient morbidity, the elimination of anterior knee instability, and a timely return of function. Osteotomies about the knee joint are an effective means of treating unicompartmental knee arthrosis. Long-term studies have demonstrated that knee osteotomy is a good surgical option for patients with unicompartmental arthritis who are considered too young for total knee arthroplasty. We describe a comprehensive treatment approach to the patient with anterior cruciate ligament deficiency and isolated medial or lateral osteoarthritis. An assessment of pain symptoms, instability symptoms, and lower extremity alignment is used to formulate a treatment plan.

Histological analysis of human meniscal allografts. A preliminary report.

BACKGROUND: Little is known about the biology of meniscal allograft transplantation in humans. In particular, little information is available about the phenotype of the cells that repopulate the allograft, whether an immune response is elicited against the graft, and whether the repopulating cells synthesize normal extracellular matrix components. METHODS: A small biopsy specimen of the meniscal allograft (twenty-eight menisci in twenty-five patients) and the adjacent synovial membrane (sixteen patients) was harvested during follow-up arthroscopy in patients who had undergone meniscal allograft transplantation at a mean of sixteen months earlier. Seventeen patients had undergone concomitant reconstruction of the anterior cruciate ligament with an allograft. Normal menisci (unimplanted allografts) and synovial specimens from age-matched controls were examined as well. All twenty-eight meniscal allografts were examined histologically. Immunohistochemical analysis was carried out on ten menisci and nine synovial specimens with use of monoclonal antibodies to class-I and class-II major histocompatibility complex antigens, CD-8, CD-11b, and CD-19 epitopes, as well as other epitopes, to demonstrate immunogenic macromolecules, cytotoxic T-lymphocytes, activated macrophages, and B-lymphocytes. RESULTS: Most of the specimens demonstrated incomplete repopulation with viable cells. The repopulating cells stained positively with phenotype markers for both synovial cells and fibroblasts. Polarized light microscopy demonstrated evidence of active remodeling of the matrix. The cells in frozen, unimplanted menisci stained positively for class-I and class-II human leukocyte antigens, indicating immunogenicity at the time of transplantation. Overall, nine of twelve specimens contained immunoreactive cells (B-lymphocytes or cytotoxic T-cells) in the meniscus or synovial tissue. However, only a small number of these cells was present. There was no evidence of frank immunological rejection. The clinical outcome (success or failure of the transplant) was not related to the overall histological score or to the presence of an immune response in the meniscal or synovial biopsy specimen. CONCLUSIONS: Human meniscal allograft transplants are repopulated with cells that appear to be derived from the synovial membrane; these cells appear to actively remodel the matrix. Although there is histological evidence of an immune response directed against the transplant, this response does not appear to affect the clinical outcome. The presence of histocompatibility antigens on the meniscal surface at the time of transplantation (even after freezing) indicates the potential for an immune response against the transplant. CLINICAL RELEVANCE: Despite the absence of frank immunological rejection, a subtle immune reaction may affect the healing, incorporation, and revascularization of the graft. It is possible that the structural remodeling associated with cellular repopulation may render the meniscus more susceptible to injury.

The effect of ciprofloxacin on tendon, paratenon, and capsular fibroblast metabolism.

The pathologic mechanisms underlying fluoroquinolone-induced tendinopathy are poorly understood. The observed incidence of tendinitis and tendon rupture in patients treated with ciprofloxacin hydrochloride suggests that the fluoroquinolone antibiotics alter tendon fibroblast metabolism. The purpose of this study was to examine the effect of ciprofloxacin on fibroblast metabolism in vitro. Canine Achilles tendon, paratenon, and shoulder capsule specimens were maintained in culture with ciprofloxacin (5, 10, or 50 microg/ml). Fibroblast proliferation, collagen synthesis, proteoglycan synthesis, and matrix-degrading activity were analyzed. Incubation of Achilles tendon, Achilles paratenon, and shoulder capsule fibroblasts with ciprofloxacin resulted in a statistically significant 66% to 68% decrease in cell proliferation compared with control cells at day 3 in culture. Ciprofloxacin caused a statistically significant 36% to 48% decrease in collagen synthesis compared with controls in all fibroblast cultures. Ciprofloxacin caused a statistically significant 14% to 60% decrease in proteoglycan synthesis in all fibroblast cell lines. Compared with unstimulated control fibroblasts, culture media from Achilles tendon, paratenon, and shoulder capsule cells that were exposed to ciprofloxacin demonstrated statistically significant increases in matrix-degrading proteolytic activity after 72 hours in culture. This study demonstrates that ciprofloxacin stimulates matrix-degrading protease activity from fibroblasts and that it exerts an inhibitory effect on fibroblast metabolism. The increase in protease activity and the inhibition of both cell proliferation and the synthesis of matrix ground substance may contribute to the clinically described tendinopathies associated with ciprofloxacin therapy.

Response of hamstring and patellar tendon grafts for anterior cruciate ligament reconstruction during cyclic tensile loading.

The efficacy of anterior cruciate ligament (ACL) reconstruction in the knee using hamstring tendon or patellar tendon grafts is thought to depend on the relative amounts of graft elongation, or creep, following postoperative rehabilitation. In this study, the creep responses of the tendinous portions of these two graft types were compared during 1 hour of cyclic loading to 200 N at 1 Hz. In the hamstring tendon grafts, strains were measured in both the tissue and in the length-augmentation tape to identify the relative contribution of this particular graft fixation to overall creep. Differences in tissue strain between graft types during cyclic loading were not statistically significant. For both types of grafts, overall graft length significantly increased after 3600 cycles while tissue creep was not significant. The greatest creep in the hamstring tendon grafts occurred at the tissue-tape interface, indicating a potential disadvantage of this composite graft construct.

Quadrilateral space syndrome: diagnosis, pathology, and treatment.

Quadrilateral space syndrome is an infrequent, recently established neurovascular compression syndrome affecting young active adults. With this syndrome, the neurovascular bundle, consisting of the posterior humeral circumflex artery (PHCA) and the axillary nerve, is compressed by fibrotic bands as it traverses the quadrilateral space. Symptoms result from compression of the axillary nerve, not from PHCA occlusion. Because of the vague, often nonspecific, clinical presentation of patients with quadrilateral space syndrome, diagnosis is challenging and requires a high index of suspicion from the orthopedist. Subclavian arteriography confirms the diagnosis. Treatment is usually conservative; operative management is reserved for selected patients. A posterior approach with detachment of the deltoid and teres minor muscles is recommended for surgical decompression and for lysis of fibrous tissue. We report two cases of persistent quadrilateral space syndrome in young adults, treated surgically, with 2-year follow-up. In the present report, diagnostic criteria, pathology, management, operative technique, and recent literature are also reviewed.

Open debridement and soft tissue release as a salvage procedure for the severely arthrofibrotic knee.

Postoperative loss of knee motion is a well-recognized phenomenon. This paper reports our results with open debridement and soft tissue release as a salvage procedure in the treatment of patients with severe arthrofibrosis on whom arthroscopic surgical techniques had failed. Eight knees (eight patients) were identified retrospectively. There were four men and four women; mean age was 29 years. All had severely restricted motion with extensive intraarticular and periarticular fibrosis. Range of motion averaged 62.5 degrees preoperatively (flexion 81 degrees, loss of extension 18.8 degrees). Patients underwent open debridement and soft tissue release to restore motion. There were no complications. Motion improved to an average of 124 degrees after surgery. Average flexion improved from 81 degrees to 125 degrees . Loss of extension improved from 18.8 degrees to 1.25 degrees. Functional outcome was good, with Lysholm II scores averaging 79. Patient satisfaction was high. There was a high incidence of patellofemoral arthritis at follow-up. Furthermore, the patellar tendon shortened approximately 6 mm over time. While we do not advocate open debridement and soft tissue release as a first-line treatment for arthrofibrosis, we do conclude that it can be effective as a salvage procedure to restore motion in the profoundly arthrofibrotic knee.

Injuries of the pectoralis major muscle: evaluation with MR imaging.

PURPOSE: To demonstrate that magnetic resonance (MR) imaging allows evaluation of injuries of the pectoralis major muscle. MATERIALS AND METHODS: Fifteen men underwent MR imaging after injury of the pectoralis major muscle. Most of the patients (nine of 15) were injured while lifting weights, notably bench-pressing. The injuries were evaluated for abnormal morphology and signal intensity, specifically the site of injury, degree of tearing, and amount of tendon retraction. RESULTS: Six injuries occurred at the musculotendinous junction, and five were treated conservatively; eight of the nine cases of distal tendon avulsion were treated with primary surgical repair. The MR imaging findings were confirmed in the nine cases treated surgically. Complete tears (three of 15) were less common than partial tears (12 of 15). The sternal and clavicular heads were torn in 10 patients, only the clavicular head was torn in two patients, and only the sternal head was torn in three patients. Acute tears (10 of 15) demonstrated hemorrhage and edema, whereas chronic tears (five of 15) demonstrated fibrosis and scarring. There was a variable amount of tendon retraction. CONCLUSION: MR imaging allows accurate evaluation of injuries of the pectoralis major muscle and enables identification of patients who would benefit from surgical repair.

Noncontrast magnetic resonance imaging of superior labral lesions. 102 cases confirmed at arthroscopic surgery.

Previous studies report that noncontrast magnetic resonance imaging is limited in the evaluation of the superior glenoid labrum. From our magnetic resonance imaging database of 2552 patients, we prospectively identified 104 patients with superior labral lesions who subsequently went on to arthroscopic surgery. Magnetic resonance images were assessed to identify fraying, flap tears, bucket-handle tears, or displaced flap of fibrocartilage. The biceps tendon was also evaluated. Patients were categorized according to Snyder's classification, and the findings on the magnetic resonance images were correlated with surgical findings. One hundred of the 104 tears suspected on the images were confirmed at surgery. There were four false-positives and two false-negatives, the former reflecting one normal labrum, two meniscoid-type labra, and one sublabral foramen. With arthroscopic surgery as the standard, magnetic resonance imaging had a sensitivity of 98.0% (100 of 102), a specificity of 89.5% (34 of 38), and an accuracy of 95.7% (134 of 140) for detection of superior labral lesions. We concluded that high-resolution noncontrast magnetic resonance imaging can accurately diagnose superior labral lesions and aid in surgical management.

Radiographic evaluation of glenohumeral kinematics: a muscle fatigue model.

The purpose of this study was to document the effect of muscle fatigue on glenohumeral kinematics. Twelve male volunteers without shoulder disease and with an average age of 27 years were studied. Glenohumeral anteroposterior radiographs were taken at 45 degrees intervals as the arm was abducted in the plane of the scapula from 0 degree to 135 degrees. This series of radiographs was performed both before and immediately after the subject performed a series of deltoid and rotator cuff fatiguing exercises. The average humeral head position or translation before and after muscle fatigue for each arm angle was compared. For all subjects, before fatigue, the position of the humeral head was below the center of the glenoid for all angles of abduction. There was essentially no change in position of the humeral head in the prefatigue state, as the arm was abducted from 0 degree to 135 degrees with no more than an average 0.3 mm of total humeral head excursion. After fatigue, excursion of the humeral head increased to an average of 2.5 mm between the tested positions. The position of the humeral head with the arm at 0 degree of abduction was lower or had migrated inferiorly compared with the rested state, with an average 1.2 mm significant increase in inferior translation. With the initiation of abduction, the humeral head demonstrated significant superior migration or translation in all positions tested. This result has important implications for conservative treatment of shoulder impingement and underscores the importance of rehabilitation to maximize the endurance and strength of the rotator cuff musculature.

The skeletally fixed knee hinge for the grossly unstable knee.

This study examined whether a skeletally fixed prefabricated knee hinge can provide the intact or unstable knee with normal motion through a specific arc of motion. Eight cadaveric knee specimens were used. The amount of motion mismatch between knee and hinge motion was evaluated at six different knee flexion angles. With all knee ligaments intact, addition of the hinge resulted in increasing amounts of joint compression with knee flexion. When all knee ligaments were cut, there was some degree of distraction with 0 degrees of knee flexion, which seemed to gradually decrease and become compressive at 80 degrees of flexion. These values were not statistically significant. In contrast, the mismatch between anterior and posterior tibial translation mismatch was statistically significant. With the ligaments intact, the addition of the hinge resulted in increased amounts of posterior tibial translation, which became significant at 80 degrees of flexion. Similarly, when the ligaments were cut with the hinge intact, there was an increasing amount of posterior tibial translation, which became significant at 60 degrees of flexion. There was also a significant amount of anterior tibial translation at 0 degrees in this group. These results indicate that the hinge allows only a limited range of motion that does not significantly alter tibial translation or joint compression or distraction. Whether this amount of motion is enough to improve the outcome of the grossly unstable knee is unknown. The use of a more sophisticated hinge system might accomplish a greater range of anatomic motion before significant mismatch occurs between hinge and knee motion.

Contact pressures at osteochondral donor sites in the knee.

The purposes of this study were to determine whether any of the commonly recommended osteochondral donor sites are nonarticulating throughout a functional range of knee motion, and to determine the differential contact pressures for these sites. Ten commonly recommended sites for osteochondral harvest were evaluated with pressure-sensitive film through a functional range of motion with a model that simulated nonweightbearing resistive extension of the knee. All 10 donor sites demonstrated a significant contact pressure through 0 degree to 110 degrees of knee motion. The different color density measurements between donor sites were also significant. Although donor sites 1, 2, 9, and 10 demonstrated significantly less contact pressure than the sites with the greatest contact pressure, the difference in mean pressures was small. No osteochondral donor site tested was free from contact pressure. It is currently unknown whether articular contact at these osteochondral donor sites will lead to degenerative changes or any other problems.

Interference screw position and hamstring graft location for anterior cruciate ligament reconstruction.

Anterior cruciate ligament reconstruction with hamstring tendon graft and interference screw fixation has recently been considered. Concerns for the use of interference screws with soft tissue grafts include damage to the graft during screw insertion, decreased fixation strength, and a decrease in the bone-tendon contact area for healing within the tunnel when the screw is placed in an eccentric position. This last concern could be addressed by placing the interference screw centrally between the four limbs of the hamstring graft. The purpose of this study was to determine the mode of failure, the pullout force, and graft slippage before graft fixation failure of hamstring tendons fixed with an interference screw positioned eccentrically in relation to the hamstring tendons verses an interference screw positioned centrally between the four graft limbs. The semitendinosus and gracilis tendons were harvested from six, fresh cadaveric specimens. Each tendon was divided into two segments of equal length. Both the semitendinosus and gracilis tendon segments were looped to form four strands. The specimens were then fixed with a bioabsorbable interference screw in the two different positions and pulled from a standardized polyurethane foam. All tendons in both groups failed by pulling out from between the interference screw and tunnel, regardless of the screw position. No tendon was cut by the screw in either group. There was no significant difference between the forces required to produce specific amounts of graft slippage between the two fixation techniques tested. There was no significant difference between the average total slippage at maximum pullout, 11.8 mm for the screw placed in the eccentric position and 13.7 mm for the screw placed in the central position. The maximum pullout force averaged 265.3 N for the screw placed in the eccentric position, and 244.7 N for the screw placed in the central position; these values were not significantly different. Placement of the interference screw in the central position did not compromise strength and it improves graft contact within the bone tunnel. Interference screw fixation, when applied against a bone plug, has been shown to consistently have a pullout force of more than 400 N.