Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Type of study
Language
Publication year range
1.
Behav Brain Res ; 380: 112447, 2020 02 17.
Article in English | MEDLINE | ID: mdl-31870777

ABSTRACT

Vascular pathologies represent the leading causes of mortality worldwide. The nervous system has evolved mechanisms to compensate for the cerebral hypoxia caused by many of these conditions. Vessel dilation and growth of new vessels are two prominent responses to hypoxia, both of which play a critical role in maintaining cerebral homeostasis. One way to facilitate cerebrovascular plasticity, and develop neuroprotection against vascular pathologies, is through aerobic exercise. The present study explored the long-term consequences of aerobic exercise on vascular structure and function in the motor cortex. Rats were assigned to a sedentary condition or were provided access to running wheels for 26 weeks. Rats were then anesthetized, and angiograms were captured using spectral domain optical coherence tomography (SD-OCT) to explore cerebrovascular reactivity in response to altered oxygen and carbon dioxide status. Following this procedure, all rats were euthanized, and unbiased stereological quantification of blood vessel density was collected from sections of the primary motor cortex infused with India ink. Results demonstrated that chronic exercise increased capillary and arteriole surface area densities and enhanced arteriole reactivity in response to hypercapnia-hypoxia, as displayed by increased vasodilation within the motor cortex of exercised animals.


Subject(s)
Hypercapnia/physiopathology , Hypoxia/physiopathology , Motor Cortex/blood supply , Neovascularization, Physiologic/physiology , Physical Conditioning, Animal/physiology , Running/physiology , Vasodilation/physiology , Animals , Arterioles/physiology , Capillaries/physiology , Male , Rats , Rats, Long-Evans , Tomography, Optical Coherence
SELECTION OF CITATIONS
SEARCH DETAIL
...