ABSTRACT
Basra, southern Iraq, was mapped for haemoglobinopathies and glucose-6-phosphate dehydrogenase (G6PD) deficiency. Of 1064 couples aged 14-60 years recruited from the Public Health Laboratory, 49 had beta-thalassaemia trait, 69 had sickle-cell trait, 2 had haemoglobin D trait, 2 had haemoglobin C trait and 1 had high persistent fetal haemoglobin. Carriers of major beta-globin disorders comprised 11.48%. G6PD deficiency was detected in 133 individuals (12.5%). Only 10 couples (0.94%) were at risk of having children affected with either sickle-cell disease or beta-thalassaemia major. These defects constitute a real health problem and necessitate a management plan and public health education for early diagnosis and therapy.
Subject(s)
Glucosephosphate Dehydrogenase Deficiency/epidemiology , Glucosephosphate Dehydrogenase Deficiency/genetics , Hemoglobinopathies/epidemiology , Hemoglobinopathies/genetics , Adolescent , Adult , Female , Fetal Hemoglobin/genetics , Gene Frequency/genetics , Genetic Carrier Screening , Genetic Counseling , Genetic Testing , Glucosephosphate Dehydrogenase Deficiency/prevention & control , Health Education , Hemoglobin C Disease/epidemiology , Hemoglobin C Disease/genetics , Hemoglobinopathies/prevention & control , Hemoglobins, Abnormal/genetics , Humans , Iraq/epidemiology , Male , Middle Aged , Molecular Epidemiology , Needs Assessment , Population Surveillance , Prevalence , Residence Characteristics/statistics & numerical data , Risk Factors , Sickle Cell Trait/epidemiology , Sickle Cell Trait/genetics , beta-Thalassemia/epidemiologyABSTRACT
Basra, southern Iraq, was mapped for haemoglobinopathies and glucose-6-phosphate dehydrogenase [G6PD] deficiency. Of 1064 couples aged 14-60 years recruited from the Public Health Laboratory, 49 had beta-thalassaemia trait, 69 had sickle-cell trait, 2 had haemoglobin D trait, 2 had haemoglobin C trait and 1 had high persistent fetal haemoglobin. Carriers of major beta-globin disorders comprised 11.48%. G6PD deficiency was detected in 133 individuals [12.5%]. Only 10 couples [0.94%] were at risk of having children affected with either sickle-cell disease or beta-thalassaemia major. These defects constitute a real health problem and necessitate a management plan and public health education for early diagnosis and therapy
