Comparison of intravenous terbutaline versus normal saline in pediatric patients on continuous high-dose nebulized albuterol for status asthmaticus.

OBJECTIVE: To determine if the addition of intravenous terbutaline provides any clinical benefit to children with acute severe asthma already on continuous high-dose nebulized albuterol. METHODS: We conducted a prospective, randomized, double blind, placebo-controlled trial on pediatric patients with acute severe asthma presenting to a large inner city tertiary children's emergency department. Consecutive patients between 2 and 17 years of age who failed acute asthma management and needed intensive care unit admission underwent informed consent and were enrolled into the study. Patients not requiring intubation were randomized to receive either intravenous terbutaline or intravenous normal saline while on continuous high-dose nebulized albuterol, ipratropium bromide, and systemic corticosteroids. Outcome measures included a clinical asthma severity score, hours on continuous nebulized albuterol, and duration of stay in the pediatric intensive care unit. In addition, electrocardiograms, electrolytes, lactic acid, and troponin I levels were obtained at routine intervals during the first 24 hours after admission. Patients who significantly worsened while enrolled in the study received intravenous aminophylline according to protocol. RESULTS: Forty-nine patients were enrolled in the study. Patients on terbutaline had a mean improvement in the clinical asthma severity score over the first 24 hours of 6.5 points compared with 4.8 points in the placebo group (P = 0.073). Patients on terbutaline spent 38.19 hours on continuous nebulized albuterol compared with their placebo counterparts who spent 51.93 hours (P = 0.25). The length of stay in the PICU was on average 12.95 hours longer for those patients in the placebo group as compared with the terbutaline group (P = 0.345). One patient was removed from the study for a significant cardiac dysrhythmia. This patient was in the terbutaline group and recovered without complications. Troponin I values at 12 hours and 24 hours were elevated in 3 patients each, all within the terbutaline group. CONCLUSIONS: No outcome measures demonstrated statistical significance. Outcome measures revealed a trend toward improvement in the terbutaline group. Before recommending routine use of intravenous terbutaline for acute severe asthma, further study to determine safety and efficacy is necessary.

Bilevel positive airway pressure in the treatment of status asthmaticus in pediatrics.

OBJECTIVES: The aim of this study was to examine the safety, patient tolerance, and possible benefit of bilevel positive airway pressure (BiPAP) in conjunction with beta-2 agonist therapy in the treatment of pediatric patients with status asthmaticus who were refractory to conventional medical therapy. METHODS: This descriptive retrospective chart review examined all patients with the diagnosis of acute asthma treated with BiPAP in an urban academic pediatric emergency department (ED) from April 1, 2003, to August 31, 2004. RESULTS: Eighty-three patients with status asthmaticus refractory to conventional pharmacological treatment were placed on BiPAP with beta-2 agonist nebulization in the ED. The number of subjects tolerating BiPAP was 73 (88%) of 83 patients. All patients placed on BiPAP in the ED were initially designated for admission to the pediatric intensive care unit (PICU). However, only 78% (57/73) were actually admitted to the PICU. Sixteen patients on BiPAP were admitted to a ward service; of these patients, none were subsequently transferred to the PICU. In addition, there was an immediate improvement in subjects' clinical status upon initiation of BiPAP, with 77% showing a decrease in respiratory rate, averaging 23.6% (range, 4%-50%), and 88% showing an improved oxygen saturation, averaging 6.6 percentage points (1-28 percentage points). There were no adverse events due to the use of BiPAP. CONCLUSIONS: These results suggest that the addition of BiPAP in treating pediatric status asthmaticus is safe and well tolerated. This intervention shows promise as a beneficial adjunct to conventional medical treatments. However, further prospective investigation is warranted to confirm these findings.

Evaluation of a Web-based education program on reducing medication dosing error: a multicenter, randomized controlled trial.

CONTEXT: The Broselow Pediatric Resuscitation Tape has been shown to be effective in reducing medication dosing error among pediatric emergency providers. However, the tape has often been used inappropriately or incorrectly. OBJECTIVE: To evaluate whether a Web-based education program on proper use of the tape could reduce medication dosing errors and time to determine dose. DESIGN, SETTING, AND PARTICIPANTS: A randomized, controlled trial conducted among 89 pediatric emergency providers from 3 study sites. INTERVENTION: All study subjects participated in a videotaped simulated stabilization scenario and were then randomly assigned to control or education group. After the intervention, all subjects participated in another simulation. MAIN OUTCOMES MEASURES: The primary outcomes included dosing deviation from accepted dose range for each medication prescribed and dosing deviation summary, calculated by averaging dosing deviation for all medications. The secondary outcomes included time to determine a dose for each medication prescribed, and dosing time summary; that is, the average time to determine doses for all medications prescribed. RESULTS: No significant difference was observed in the demographic characteristics of the 2 groups. After the educational intervention, the average (12.6% vs. 24.9%) and median (7.1% vs. 20.1%) dosing deviation summary were much lower in the education group than in the control group. The difference in the median dosing deviation summary between the 2 groups was statistically significant (P = 0.0002). Similar results were observed for the dosing time. The education group demonstrated a lower average (16 vs. 20 seconds) and lower median (15 vs. 18 seconds) dosing time summary than the control group. The difference in the median dosing time summary between the 2 groups was statistically significant (P = 0.02). Analysis of each medication prescribed indicated that the decrease in the dosing deviation and dosing time in the education group was most obvious for several specific medications. CONCLUSIONS: The Web-based education program on the proper use of the Broselow Pediatric Resuscitation Tape could improve dosing accuracy and reduce dosing time.

A comparison of the influence of hospital-trained, ad hoc, and telephone interpreters on perceived satisfaction of limited English-proficient parents presenting to a pediatric emergency department.

BACKGROUND: Latinos are the fastest growing minority group in the United States with a significant percentage of this population having limited English proficiency. OBJECTIVE: To determine whether mode of interpretation influences satisfaction of limited English-proficient parents presenting to a tertiary care pediatric emergency department. DESIGN: One hundred eighty parents of patients presenting to a pediatric emergency department were surveyed after receiving services from one of the following interpreters: hospital-trained, ad hoc, or telephone. An English-proficient comparison group of 60 parents of any ethnicity was also surveyed (total N = 240). RESULTS: Parents were significantly more satisfied (P < 0.001) with hospital-trained interpreters. While no significant difference was found in overall visit satisfaction, there were significant differences in several other outcome variables. When hospital-trained interpreters were used, parents were significantly more satisfied (P < 0.001) with their physicians and nurses. With regard to the ability to communicate with pediatric emergency department personnel, parents using hospital-trained interpreters averaged significantly higher scores (P < 0.001) than the telephone group. Quality-of-care scores were significantly higher (P < 0.001) for parents assigned to hospital-trained interpreters than for the other forms of interpretation. English-proficient parents scored highest in the following categories: ability to communicate, quality of care, and overall visit satisfaction. Parents using hospital-trained interpreters scored higher than English-proficient parents when questioned about physician and nursing satisfaction. CONCLUSION: Hospital-trained interpreters are a valuable and needed resource to facilitate communication with limited English-proficient patients and families. Other interpretation services are useful but have limitations.

Capnometry for noninvasive continuous monitoring of metabolic status in pediatric diabetic ketoacidosis.

OBJECTIVE: To determine the utility of continuous noninvasive capnometry for monitoring pediatric patients with diabetic ketoacidosis as assessed by the agreement between end-tidal carbon dioxide (PetCO2) and PCO2 DESIGN: Clinical, prospective, observational study. SETTING: University affiliated children's hospital. INTERVENTIONS: Patients with diabetic ketoacidosis were monitored with an oral/nasal carbon dioxide (CO2) sampling cannula while in the emergency department. Laboratory studies were ordered per protocol. PetCO2 values were correlated with respiratory rate, PCO2, and pH. MEASUREMENTS AND MAIN RESULTS: One hundred twenty-one patients were monitored for 5.9 +/- 0.32 hrs. The average (mean +/- sd) initial values for pH were 7.08 +/- 0.18; respiratory rate, 35.1 +/- 9.1 breaths/min; PetCO2, 18.6 +/- 10.8 torr; and venous PCO2, 20.2 +/- 10.6 torr. At the conclusion of the observation period, averages were pH, 7.29 +/- 0.05; respiratory rate, 22.4 +/- 3.7 breaths/min; PetCO2, 35.3 +/- 5.8 torr; and venous PCO2, 36.8 +/- 5.3 torr. For all 592 observations, the correlations between PetCO2 and venous PCO2 (r =.92, p =.0001), PetCO2 and pH (r =.88, p =.0001), Petco2 and respiratory rate (r = -.79, p =.0001), and respiratory rate and pH (r = -.80, p =.0001) were statistically significant and the correlations with respiratory rate were inversely related to pH and PetCO2. The difference scores were not related to the average scores for initial readings (r = -.073, p =.43), final readings (r = -.124, p =.18), and overall readings (r =.057, p =.17). Limits of agreement between the two methods were established with PetCO2 lower than venous PCO2 with 95% limits of agreement 0.8 +/- 8.3 (2 sd) torr. CONCLUSIONS: PetCO2 monitoring of patients with diabetic ketoacidosis provides an accurate estimate of PCO2. Noninvasive PetCO2 sampling may be useful in patients with diabetic ketoacidosis to allow for continuous monitoring of patients.

Tap water for irrigation of lacerations.

This study was designed to compare the infection rates of simple lacerations irrigated with tap water versus sterile normal saline before repair. Patients with simple lacerations to an extremity that were less than 8 hours from injury were prospectively enrolled. Exclusions from the study were: dog bites, hand lacerations, immunocompromised patients, and those on antibiotics at the time of injury. Patients who qualified were randomized to receive tap water or normal saline for wound irrigation. Before and after irrigation, wound cultures were obtained. After the procedure was complete, patients were scheduled for a 48 hour follow-up wound check. A total of 46 patients were enrolled in the study. Twenty-four patients were randomized to the normal saline group and 21 were assigned to receive tap water irrigation. There were 2 infected lacerations in both the tap water and normal saline groups. The organisms cultured from the wounds in both groups were similar and there was no difference in colony counts when tap water was used. The use of tap water for the irrigation of lacerations does not result in the growth of unusual organisms or increase the colony counts of organisms. Wound infection rates were the same in both groups. This pilot study suggests that the use of tap water for irrigation of wounds may be safe. Further validation is necessary.