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Hypertens Pregnancy ; 42(1): 2238086, 2023 Dec.
Article in English | MEDLINE | ID: mdl-37477196

ABSTRACT

OBJECTIVE: To study associations between the first-trimester maternal determinants of renin-angiotensin-aldosterone system (RAAS) activation and telomere length (TL) in pregnancies conceived natural and after IVF/ICSI. METHODS: In 145 pregnancies of the Rotterdam Periconception cohort renin, prorenin and aldosterone concentrations were measured in maternal blood at 9 weeks gestational age (GA). TL was measured by qPCR at 20 weeks GA. RESULTS: A significantly negative correlation was found between renin and TL, which was attenuated for prorenin but not observed for aldosterone. Maternal TL was significantly shorter in pregnancies conceived after in-vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) compared to natural pregnancies. CONCLUSION: The negative association between first-trimester maternal renin and maternal TL, and the shorter maternal TL in women after IVF/ICSI treatment compared to natural pregnancies, substantiates the role of excessive RAAS activation.


Subject(s)
Renin-Angiotensin System , Sperm Injections, Intracytoplasmic , Pregnancy , Male , Female , Humans , Pregnancy Trimester, First , Renin , Aldosterone , Semen , Fertilization , Fertilization in Vitro , Telomere
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