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2.
AJNR Am J Neuroradiol ; 43(12): 1784-1791, 2022 12.
Article in English | MEDLINE | ID: mdl-36456082

ABSTRACT

BACKGROUND AND PURPOSE: Social media has made inroads in medical education. We report the creation and 3-year (2018-2021) longitudinal assessment of the American Society of Head and Neck Radiology Case of the Week (#ASHNRCOTW), assessing viewership, engagement, and impact of the coronavirus disease 2019 (COVID-19) pandemic on this Twitter-based education initiative. MATERIALS AND METHODS: Unknown cases were tweeted from the American Society of Head and Neck Radiology account weekly. Tweet impressions (number of times seen), engagements (number of interactions), and new followers were tabulated. A social media marketing platform identified worldwide distribution of Twitter followers. Summary and t test statistics were performed. RESULTS: #ASHNRCOTW was highly visible with 2,082,280 impressions and 203,137 engagements. There were significantly greater mean case impressions (9917 versus 6346), mean case engagements (1305 versus 474), case engagement rates (13.06% versus 7.76%), mean answer impressions (8760 versus 5556), mean answer engagements (908 versus 436), answer engagement rates (10.38% versus 7.87%), mean total (case + answer) impressions (18,677 versus 11,912), mean total engagements (2214 versus 910), and total engagement rates (11.79% versus 7.69%) for cases published after the pandemic started (all P values < .001). There was a significant increase in monthly new followers after starting #ASHNRCOTW (mean, 134 versus 6; P < .001) and significantly increased monthly new followers after the pandemic started compared with prepandemic (mean, 178 versus 101; P = .003). The American Society of Head and Neck Radiology has 7564 Twitter followers throughout 130 countries (66% outside the United States). CONCLUSIONS: Social media affords substantial visibility, engagement, and global outreach for radiology education. #ASHNRCOTW viewership and engagement increased significantly during the COVID-19 pandemic.


Subject(s)
COVID-19 , Radiology , Social Media , Humans , United States , Pandemics/prevention & control , Radiology/education , Educational Status
3.
Clin Radiol ; 77(3): 167-178, 2022 03.
Article in English | MEDLINE | ID: mdl-34799048

ABSTRACT

Non-invasive imaging plays an increasingly important role in assessing the extracranial vasculature. The applications of computed tomography angiography (CTA) and magnetic resonance angiography (MRA) continue to expand with growing demand for stroke imaging and anatomical assessment preceding vascular intervention. Imaging of the neck is performed for a variety of clinical indications with different imaging protocols. Even on non-dedicated vascular imaging, such as soft-tissue studies, the neck vessels and the proximal aortic arch are readily evaluable, providing an opportunity to promptly identify critical vascular abnormalities with significant therapeutic implications. Vascular abnormalities can have non-specific clinical signs and symptoms resulting in delays in both diagnosis and treatment. Understanding the common locations and appearances of vascular pathologies will help the radiologist to develop a systematic search strategy for evaluating neck imaging. Not only is identifying the pathology of paramount importance but also understanding how imaging further prognosticates and determines treatment options. As imaging techniques advance, further vascular radiological features are recognised with therapeutic implications, particularly for stroke. Such features include plaque morphology and vulnerability with imaging helping to identify those at high risk of stroke and recurrent strokes. Using clinical cases from a quaternary care academic medical centre a spectrum of clinically relevant arterial pathologies and associated features that could add further benefit to the radiology report are illustrated. A suggested systematic approach to evaluating the vasculature on neck imaging is also presented.


Subject(s)
Computed Tomography Angiography , Magnetic Resonance Angiography , Neck/blood supply , Vascular Diseases/diagnostic imaging , Aortic Dissection/diagnostic imaging , Aneurysm, False/diagnostic imaging , Aorta, Thoracic/diagnostic imaging , Arteritis/diagnostic imaging , Blood Vessels/abnormalities , Blood Vessels/diagnostic imaging , Carotid Artery Diseases/diagnostic imaging , Delayed Diagnosis , Humans , Incidental Findings , Neck/diagnostic imaging , Plaque, Atherosclerotic/complications , Plaque, Atherosclerotic/diagnostic imaging , Stroke/diagnostic imaging , Stroke/etiology
4.
AJNR Am J Neuroradiol ; 39(12): 2378-2384, 2018 12.
Article in English | MEDLINE | ID: mdl-30385469

ABSTRACT

BACKGROUND AND PURPOSE: Patient preparation for myelography and postprocedural monitoring varies widely between practices, despite published guidelines. Our aim was to examine the current practice variations in discontinuing reportedly seizure threshold-lowering medications before myelography and to assess the reported incidence of postmyelographic seizures. MATERIALS AND METHODS: An e-mail survey was sent to American Society of Neuroradiology members concerning the number of postmyelographic seizures experienced in the past 5 years, the presence of an institutional policy for discontinuing seizure threshold-lowering medications, and the type of myelographic contrast used. We compared the postmyelographic seizure frequency in the responses. RESULTS: Of 700 survey responses, 57% reported that they do not discontinue seizure threshold-lowering medications before myelography. Most (97%) indicated never having a patient experience a seizure following myelography. The number of postmyelographic seizures between those who discontinue seizure threshold-lowering medications and those who do not was not statistically significant (OR = 2.13; 95% CI, 0.91-4.98; P = .08). Most (95%) reported using nonionic hypo-osmolar agents. CONCLUSIONS: Survey results revealed widely variable practices for patient myelography preparation and postprocedural monitoring. We found no difference in reported seizures between those who discontinued seizure threshold-lowering medications and those who did not. In light of our findings, we propose that discontinuing reportedly seizure threshold-lowering medications is not warranted with the current nonionic water-soluble contrast agents and may be potentially harmful in some instances. This work supports revision of existing recommendations to withhold such medications before myelography.


Subject(s)
Myelography/methods , Practice Guidelines as Topic , Practice Patterns, Physicians' , Anticonvulsants/therapeutic use , Guideline Adherence/statistics & numerical data , Humans , Male , Myelography/adverse effects , Myelography/standards , Practice Guidelines as Topic/standards , Seizures/drug therapy , Seizures/epidemiology , Surveys and Questionnaires
5.
AJNR Am J Neuroradiol ; 39(11): 2007-2013, 2018 11.
Article in English | MEDLINE | ID: mdl-30337437

ABSTRACT

BACKGROUND AND PURPOSE: Demyelination is a recently recognized cause of FLAIR hyperintensities associated with developmental venous anomalies. Our purpose was to quantify the prevalence of white matter signal abnormalities associated with developmental venous anomalies in patients with multiple sclerosis compared with controls. MATERIALS AND METHODS: A retrospective, blinded, multireader study compared the prevalence of FLAIR hyperintense signal abnormalities adjacent to developmental venous anomalies in patients with MS compared with controls (patients with developmental venous anomalies without MS). Study findings were positive if a central vein was demonstrated using FLAIR and contrast-enhanced fat-saturated T1 sequences. Imaging parameters also included developmental venous anomaly location, developmental venous anomaly drainage, white matter lesion size, and depth of white matter lesions. Clinical parameters included age, sex, and the presence of confounding variables (hypertension, diabetes, migraines, and/or vasculopathy). RESULTS: FLAIR signal abnormality was present around 47.3% (35/74) of developmental venous anomalies in patients with MS, and 13.5% (10/74) of developmental venous anomalies in the control group (P < .001). The multivariate logistic regression model controlling for covariates (including migraines, hypertension, diabetes mellitus, vasculopathy, age, sex, and drainage direction of developmental venous anomalies) showed that the odds of FLAIR hyperintensity around developmental venous anomalies was 6.7-fold higher in patients with MS (relative risk MS = 6.68; 95% CI, 2.79-15.97; P < .001). CONCLUSIONS: The association of developmental venous anomalies and FLAIR hyperintensities was more common in patients with MS, which suggests that the underlying demyelinating pathologic process of MS may be the cause of this propensity in patients with MS. Impaired venous drainage in the territory of developmental venous anomalies may predispose to development of these lesions, and an associated central vein is helpful in understanding an atypical location of MS plaques.


Subject(s)
Arteriovenous Fistula/epidemiology , Intracranial Arteriovenous Malformations/epidemiology , Multiple Sclerosis/diagnostic imaging , Multiple Sclerosis/epidemiology , Adult , Arteriovenous Fistula/diagnostic imaging , Comorbidity , Female , Humans , Intracranial Arteriovenous Malformations/diagnostic imaging , Magnetic Resonance Imaging/methods , Male , Middle Aged , Multiple Sclerosis/pathology , Retrospective Studies
6.
AJNR Am J Neuroradiol ; 39(1): 97-101, 2018 01.
Article in English | MEDLINE | ID: mdl-28912286

ABSTRACT

We present 5 cases of demyelination in patients diagnosed with multiple sclerosis that are closely associated with a developmental venous anomaly. Although the presence of a central vein is a known phenomenon with multiple sclerosis plaques, demyelination occurring around developmental venous anomalies is an underreported phenomenon. Tumefactive demyelination can cause a diagnostic dilemma because of its overlapping imaging findings with central nervous system neoplasm. The relationship of a tumefactive plaque with a central vein can be diagnostically useful, and we suggest that if such a lesion is closely associated with a developmental venous anomaly, an inflammatory or demyelinating etiology should be a leading consideration.


Subject(s)
Central Nervous System Vascular Malformations/pathology , Multiple Sclerosis/pathology , Adult , Demyelinating Diseases/pathology , Female , Humans , Magnetic Resonance Imaging , Male , Middle Aged
7.
AJNR Am J Neuroradiol ; 39(2): 344-349, 2018 Feb.
Article in English | MEDLINE | ID: mdl-29217745

ABSTRACT

BACKGROUND AND PURPOSE: Esthesioneuroblastoma is a neuroectodermal tumor that commonly arises in the nasal cavity olfactory recess and, when isolated to the intranasal cavity, can be indistinguishable from benign processes. Because lesional aggressiveness requires a more invasive operation for resection than polypectomy, patients with isolated intranasal lesions were studied to define distinguishing CT characteristics. MATERIALS AND METHODS: Patients with intranasal esthesioneuroblastoma and controls without esthesioneuroblastoma with olfactory recess involvement were identified by using a report search tool. Studies demonstrating skull base invasion and/or intracranial extension were excluded. The imaging spectrum of these lesions was reviewed on both CT and MR imaging, and CT findings were compared with those of controls without esthesioneuroblastoma. Two blinded readers assessed subjects with esthesioneuroblastomas and controls without esthesioneuroblastoma and, using only CT criteria, rated their level of suspicion for esthesioneuroblastoma in each case. RESULTS: Eight histologically proved cases of intranasal esthesioneuroblastoma were reviewed. All cases had CT demonstrating 3 main findings: 1) an intranasal polypoid lesion with its epicenter in a unilateral olfactory recess, 2) causing asymmetric olfactory recess widening, and 3) extending to the cribriform plate. Twelve patients with non-esthesioneuroblastoma diseases involving the olfactory recess were used as controls. Using these 3 esthesioneuroblastoma CT criteria, 2 blinded readers evaluating patients with esthesioneuroblastoma and controls had good diagnostic accuracy (area under the curve = 0.85 for reader one, 0.81 for reader 2) for predicting esthesioneuroblastoma. CONCLUSIONS: Esthesioneuroblastoma can present as a well-marginated intranasal lesion that unilaterally widens the olfactory recess. CT patterns can help predict esthesioneuroblastoma, potentially preventing multiple operations by instigating the correct initial operative management.


Subject(s)
Esthesioneuroblastoma, Olfactory/diagnostic imaging , Nasal Cavity/diagnostic imaging , Nasal Polyps/diagnostic imaging , Nose Neoplasms/diagnostic imaging , Tomography, X-Ray Computed/methods , Adult , Aged , Esthesioneuroblastoma, Olfactory/pathology , Female , Humans , Male , Middle Aged , Nasal Cavity/pathology , Nasal Polyps/pathology , Nose Neoplasms/pathology
8.
Am J Transplant ; 17(8): 2117-2128, 2017 Aug.
Article in English | MEDLINE | ID: mdl-28226404

ABSTRACT

Histologic assessment of kidney transplant biopsies relies on cortex rather than medulla, but for microarray studies, the proportion cortex in a biopsy is typically unknown and could affect the molecular readings. The present study aimed to develop a molecular estimate of proportion cortex in biopsies and examine its effect on molecular diagnoses. Microarrays from 26 kidney transplant biopsies divided into cortex and medulla components and processed separately showed that many of the most significant differences were in glomerular genes (e.g. NPHS2, NPHS1, CLIC5, PTPRO, PLA2R1, PLCE1, PODXL, and REN). Using NPHS2 (podocin) to estimate proportion cortex, we examined whether proportion cortex influenced molecular assessment in the molecular microscope diagnostic system. In 1190 unselected kidney transplant indication biopsies (Clinicaltrials.govNCT01299168), only 11% had <50% cortex. Molecular scores for antibody-mediated rejection, T cell-mediated rejection, and injury were independent of proportion cortex. Rejection was diagnosed in many biopsies that were mostly or all medulla. Agreement in molecular diagnoses in paired cortex/medulla samples (23/26) was similar to biological replicates (32/37). We conclude that NPHS2 expression can estimate proportion cortex; that proportion cortex has little influence on molecular diagnosis of rejection; and that, although histology cannot assess medulla, rejection does occur in medulla as well as cortex.


Subject(s)
Biomarkers/metabolism , Graft Rejection/diagnosis , Kidney Cortex/pathology , Kidney Medulla/pathology , Kidney Transplantation/adverse effects , Adolescent , Adult , Aged , Aged, 80 and over , Child , Female , Follow-Up Studies , Gene Expression Profiling , Graft Rejection/etiology , Graft Survival , Humans , Kidney Cortex/injuries , Kidney Cortex/metabolism , Kidney Failure, Chronic/surgery , Kidney Medulla/injuries , Kidney Medulla/metabolism , Male , Middle Aged , Postoperative Complications , Prognosis , Young Adult
9.
AJNR Am J Neuroradiol ; 37(6): 1185-9, 2016 Jun.
Article in English | MEDLINE | ID: mdl-26869468

ABSTRACT

BACKGROUND AND PURPOSE: Rhabdomyosarcoma and Langerhans cell histiocytosis are malignant lesions that can affect the skull base with similar radiographic characteristics on CT and MR imaging. We hypothesized that location within the temporal bone determined radiographically can provide useful adjunctive information in differentiating these distinct neoplasms. MATERIALS AND METHODS: We identified patients with Langerhans cell histiocytosis and rhabdomyosarcoma by using an imaging data base and International Classification of Diseases, Ninth Revision codes at a tertiary care academic medical center. Cross-sectional images were reviewed by a neurotologist and neuroradiologist, who evaluated the location of the lesions and scored each subsite-middle ear, mastoid, petrous apex, retrosigmoid/posterior fossa-on a scale of 0 (no involvement), 1 (partial), or 2 (complete involvement). RESULTS: We identified 12 patients representing 14 cases of Langerhans cell histiocytosis, and 9 patients representing 9 cases of rhabdomyosarcoma. For patients with Langerhans cell histiocytosis, mastoid involvement was rated 23/28 (82%) compared with 6/18 (33%) with rhabdomyosarcoma (P = .001). Langerhans cell histiocytosis was present in only the anterior portion of the temporal bone (petrous apex and middle ear) in 1 case (7.1%) and in the anterior portion of the temporal bone only in 5/9 (55%) cases of rhabdomyosarcoma (P = .018). The cortical bone was more commonly involved in Langerhans cell histiocytosis, 11/28 (39%) of cases compared with 2/18 (11%) cases in rhabdomyosarcoma (P < .05). CONCLUSIONS: These results indicate that lesions involving only the anterior portion of the temporal bone (petrous apex and middle ear) are more likely to be rhabdomyosarcoma. Lesions involving the mastoid are more likely to be Langerhans cell histiocytosis. This difference in primary location may be helpful in predicting the pathology of these lesions on the basis of imaging.


Subject(s)
Histiocytosis, Langerhans-Cell/diagnostic imaging , Rhabdomyosarcoma/diagnostic imaging , Skull Base Neoplasms/diagnostic imaging , Temporal Bone/diagnostic imaging , Child , Cross-Sectional Studies , Diagnosis, Differential , Female , Histiocytosis, Langerhans-Cell/pathology , Humans , Image Interpretation, Computer-Assisted , Male , Rhabdomyosarcoma/pathology , Skull Base Neoplasms/pathology , Temporal Bone/pathology , Tomography, X-Ray Computed
10.
Aging Ment Health ; 19(7): 571-5, 2015 Jul.
Article in English | MEDLINE | ID: mdl-25847497

ABSTRACT

Since the publication of A Measure of Quality of Life in Early Old Age: The Theory, Development and Properties of a Needs Satisfaction Model (CASP-19) just over 10 years ago, the scale has gone on to be used in a wide variety of studies in over 20 countries across the world and the original paper has become the most highly cited paper for Aging and Mental Health. Therefore it was felt that it was a good time to look back and reflect on the developments in the use of the scale as well as to look forward to what new research is being done and could be done with the measure. To this end we are extremely grateful for the editors for allowing us to bring together a collection of papers that represent cutting edge research using the CASP scale. These papers cover a wide variety of issues, from working conditions to religiosity, from a range of countries, covering Western and Eastern Europe as well as Africa. Each makes an important individual contribution to our understanding of the factors that influence quality of life in later life as well as pointing to the limitations of the measure and future work that can be done in this area.


Subject(s)
Aging/psychology , Psychometrics/instrumentation , Quality of Life/psychology , Surveys and Questionnaires/standards , Biomedical Research/trends , Humans
11.
AJNR Am J Neuroradiol ; 35(12): 2366-70, 2014 Dec.
Article in English | MEDLINE | ID: mdl-25034778

ABSTRACT

BACKGROUND AND PURPOSE: While enhanced T1WI is considered the "gold standard" for detection of internal auditory canal pathology, unenhanced fluid-sensitive sequences have shown high sensitivity for lesion identification. Our purpose was to evaluate the diagnostic accuracy of an unenhanced MR imaging protocol using axial CISS and coronal T2WI for detection of small (10 mm or less) internal auditory canal lesions. MATERIALS AND METHODS: Twenty-three patients with small internal auditory canal lesions and 13 patients without lesions who had undergone MR imaging using the screening protocol and confirmatory gadolinium-enhanced thin section T1WI were identified. Two blinded neuroradiologists retrospectively evaluated all examinations using 1) only axial CISS, 2) only coronal T2WI, and 3) axial and coronal sequences together. Accuracy, specificity, sensitivity, and interobserver agreement were assessed. RESULTS: Median maximum lesion dimension was 4 mm (range, 2-10 mm). Accuracy, specificity, and sensitivity for axial CISS alone were 0.94, 0.96, and 0.91 for observer 1 and 0.94, 0.92, and 1.00 for observer 2. The data for the coronal T2WI sequence only were 0.94, 0.96, and 0.91 for observer 1, and 0.99, 1.00, and 0.96 for observer 2. Using axial and coronal sequences, the data were 0.97, 0.96, and 1.00 for observer 1, and 0.99, 0.98, and 1.00 for observer 2. κ coefficients were 0.84 for the axial sequence only, 0.90 for coronal only, and 0.91 for axial and coronal both. CONCLUSIONS: Screening noncontrast MR imaging using a combination of axial CISS and coronal T2WI sequences can detect small internal auditory canal lesions with 100% sensitivity and excellent interobserver agreement.


Subject(s)
Labyrinth Diseases/diagnosis , Mass Screening , Neuroma, Acoustic/diagnosis , Semicircular Canals/pathology , Adult , Aged , Female , Humans , Image Interpretation, Computer-Assisted/methods , Magnetic Resonance Imaging/methods , Male , Middle Aged , Observer Variation , Retrospective Studies , Sensitivity and Specificity
12.
AJNR Am J Neuroradiol ; 35(8): 1642-6, 2014 Aug.
Article in English | MEDLINE | ID: mdl-24763415

ABSTRACT

BACKGROUND AND PURPOSE: The STIR sequence is routinely used to assess acute traumatic osseous injury. Because the composition of the odontoid in older individuals may be altered with osteopenia and decreased vascularity, the STIR sequence may not accurately depict the acuity of an odontoid fracture. The purpose of this study was to evaluate the reliability of the STIR sequence to differentiate acute-versus-chronic type II odontoid fractures in older patients, particularly those with osteopenia. MATERIALS AND METHODS: A retrospective review was performed for patients with type II odontoid fractures during a 10-year period with both CT and MR imaging performed within 24 hours of injury. Patients were paired with controls of similar ages and were grouped by age. The STIR images were evaluated in a blinded fashion for the presence of hyperintensity in the odontoid. Demographic and clinical characteristics were also recorded. RESULTS: Seventy-five patients with type II odontoid fracture and 75 healthy controls (mean and median age of 57 years) were identified. The sensitivity of STIR to detect fracture in the age group 57 years and older was significantly worse than that in the age group younger than 57 years (54% and 82%, respectively; P = .018). CONCLUSIONS: Older patients, particularly those with osteopenia, may have acute odontoid injuries without corresponding STIR hyperintensity. Additionally, interobserver agreement in STIR interpretation decreases with increasing patient age. As such, in this patient population, in which the presence of bone marrow edema as an indicator of fracture acuity may impact therapeutic decisions, correlation with CT findings and clinical history is crucial.


Subject(s)
Multimodal Imaging/methods , Odontoid Process/injuries , Spinal Fractures/diagnosis , Adolescent , Adult , Aged , Female , Humans , Magnetic Resonance Imaging/methods , Male , Middle Aged , Reproducibility of Results , Retrospective Studies , Tomography, X-Ray Computed/methods , Young Adult
13.
Clin Radiol ; 69(1): e33-6, 2014 Jan.
Article in English | MEDLINE | ID: mdl-24156799

ABSTRACT

AIM: To test the hypothesis that computed tomographic angiography (CTA) can identify carotid body enlargement in patients with sympathetically mediated diseases. MATERIALS AND METHODS: A retrospective chart review of all patients obtaining CTAs of the cervical vasculature at University of Utah Health Sciences Center over a 6-month period was performed. Widest axial measurements of both carotid bodies were performed on a picture archiving and communication system (PACS). Statistical analysis was then performed to compare the mean carotid body size between control patients and patients with diabetes mellitus, hypertension, and congestive heart failure. RESULTS: Measurements were performed on 288 patients, with 134 controls. Of the remaining 154, 72 patients had diabetes mellitus, 46 had congestive heart failure, and 130 had hypertension. The control patients had a mean carotid body diameter of 2.3 mm. There was a statistically significant (p < 0.01) 20-25% increase in mean diameter with diabetes mellitus (2.8 mm), hypertension (2.7 mm), and congestive heart failure (2.7 mm; p < 0.01). CONCLUSIONS: This study found a 20-25% larger mean carotid body size in patients with diabetes mellitus, hypertension, and congestive heart failure relative to controls. However, this small enlargement should not mimic other carotid body diseases, such as a paraganglionoma. Moreover, these findings further support the proposed functional relationship between the carotid body and sympathetically mediated disease states.


Subject(s)
Carotid Body/diagnostic imaging , Cerebral Angiography/methods , Tomography, X-Ray Computed/methods , Adult , Carotid Body/pathology , Case-Control Studies , Comorbidity , Contrast Media , Female , Humans , Iopamidol , Male , Middle Aged , Retrospective Studies
14.
AJNR Am J Neuroradiol ; 32(6): 1096-9, 2011.
Article in English | MEDLINE | ID: mdl-21393408

ABSTRACT

BACKGROUND AND PURPOSE: Advances in multidetector CT provide exquisite detail with improved delineation of the normal anatomic structures in the head and neck. The carotid body is 1 structure that is now routinely depicted with this new imaging technique. An understanding of the size range of the normal carotid body will allow the radiologist to distinguish patients with prominent normal carotid bodies from those who have a small carotid body paraganglioma. MATERIALS AND METHODS: We performed a retrospective analysis of 180 CTAs to assess the imaging appearance of the normal carotid body in its expected anatomic location. RESULTS: The carotid body was detected in >80% of carotid bifurcations. The normal size range measured from 1.1 to 3.9 mm ± 2 SDs, which is consistent with the reported values from anatomic dissections. CONCLUSIONS: An ovoid avidly enhancing structure at the inferomedial aspect of the carotid bifurcation within the above range should be considered a normal carotid body. When the carotid body measures >6 mm, a small carotid body paraganglioma should be suspected and further evaluated.


Subject(s)
Angiography/methods , Carotid Body/diagnostic imaging , Tomography, X-Ray Computed/methods , Adolescent , Adult , Female , Humans , Male , Middle Aged , Young Adult
15.
AJNR Am J Neuroradiol ; 31(7): 1283-9, 2010 Aug.
Article in English | MEDLINE | ID: mdl-20299438

ABSTRACT

BACKGROUND AND PURPOSE: Occlusion of the AOP results in a characteristic pattern of ischemia: bilateral paramedian thalamus with or without midbrain involvement. Although the classic imaging findings are often recognized, only a few small case series and isolated cases of AOP infarction have been reported. The purpose of this study was to characterize the complete imaging spectrum of AOP infarction on the basis of a large series of cases obtained from multiple institutions. MATERIALS AND METHODS: Imaging and clinical data of 37 patients with AOP infarction from 2000 to 2009 were reviewed retrospectively. The primary imaging criterion for inclusion was an abnormal signal intensity on MR imaging and/or hypoattenuation on CT involving distinct arterial zones of the bilateral paramedian thalami with or without rostral midbrain involvement. Patients were excluded if there was a neoplastic, infectious, or inflammatory etiology. RESULTS: We identified 4 ischemic patterns of AOP infarction: 1) bilateral paramedian thalamic with midbrain (43%), 2) bilateral paramedian thalamic without midbrain (38%), 3) bilateral paramedian thalamic with anterior thalamus and midbrain (14%), and 4) bilateral paramedian thalamic with anterior thalamus without midbrain (5%). A previously unreported finding (the "V" sign) on FLAIR and DWI sequences was identified in 67% of cases of AOP infarction with midbrain involvement and supports the diagnosis when present. CONCLUSIONS: The 4 distinct patterns of ischemia identified in our large case series, along with the midbrain V sign, should improve recognition of AOP infarction and assist with the neurologic evaluation and management of patients with thalamic strokes.


Subject(s)
Anterior Cerebral Artery/pathology , Cerebral Infarction/pathology , Magnetic Resonance Imaging , Stroke/pathology , Thalamus/blood supply , Thalamus/pathology , Adult , Aged , Aged, 80 and over , Angiography, Digital Subtraction , Anterior Cerebral Artery/diagnostic imaging , Cerebral Angiography , Cerebral Infarction/diagnostic imaging , Female , Humans , Male , Mesencephalon/blood supply , Mesencephalon/diagnostic imaging , Mesencephalon/pathology , Middle Aged , Retrospective Studies , Stroke/diagnostic imaging , Thalamus/diagnostic imaging , Tomography, X-Ray Computed
16.
J Clin Microbiol ; 47(6): 1824-9, 2009 Jun.
Article in English | MEDLINE | ID: mdl-19357201

ABSTRACT

We used a PCR method to quantify the loads of Chlamydia trachomatis organisms in self-collected urine and vulvovaginal swab (VVS) samples from 93 women and 30 men participating in the Chlamydia Screening Studies Project, a community-based study of individuals not seeking health care. For women, self-collected VVS had a higher mean chlamydial load (10,405 organisms/ml; 95% confidence interval [95% CI], 5,167 to 21,163 organisms/ml) than did first-void urines (FVU) (503 organisms/ml; 95% CI, 250 to 1,022 organisms/ml; P < 0.001). Chlamydial loads in female and male self-collected FVU specimens were similar (P = 0.634). The mean chlamydial load in FVU specimens decreased with increasing age in females and males. There was no strong statistical evidence of differences in chlamydial load in repeat male and female FVU specimens taken when patients attended for treatment a median of 23.5 (range, 14 to 62) and 28 (range, 13 to 132) days later, respectively, or in VVS taken a median of 35 (range, 14 to 217) days later. In this study, chlamydial load values for infected persons in the community who were not seeking treatment were lower than those published in other studies involving symptomatic patients attending clinical settings. This might have implications for estimates of the infectiousness of chlamydia. The results of this study provide a scientific rationale for preferring VVS to FVU specimens from women.


Subject(s)
Chlamydia Infections/diagnosis , Chlamydia Infections/microbiology , Chlamydia trachomatis/isolation & purification , Community-Acquired Infections/microbiology , Polymerase Chain Reaction/methods , Adolescent , Adult , Female , Humans , Male , Self-Examination/methods , Urine/microbiology , Vagina/microbiology , Vulva/microbiology , Young Adult
17.
J Epidemiol Community Health ; 62(11): 987-91, 2008 Nov.
Article in English | MEDLINE | ID: mdl-18854503

ABSTRACT

BACKGROUND: Resilience is having good outcomes despite adversity and risk and could be described in terms of preserving the same level of the outcome or rebounding back to that level after an initial set back. Using the latter definition, resilience as "bouncing back", this paper aims (1) to identify those members of a panel survey who demonstrated resilience, and (2) to identify the characteristics of the resilient individuals and the predictors of their resilience. METHODS: The study subjects were the 3581 participants in the British Household Panel Survey, selected from waves 1-14, who satisfied three requirements: exposure to an adversity; availability of consecutive General Health Questionnaire (GHQ)-12 scores; aged 50 or more years. The primary outcome variable was resilience, operationalised as a GHQ-12 score that increased after exposure to adversity and returned to its pre-exposure level in the next (after 1 year) wave of the survey. The adversities were: functional limitation; bereavement or marital separation; poverty. RESULTS: The prevalence of resilience, as defined, was 14.5%. After adjusting for regression to the mean, the GHQ-12 score of the resilient dropped by a mean of 3.6 points in the post-adversity period. Women predominated among the resilient, with this gender difference stronger among older women than younger women. The resilient were more likely to have high social support than the non-resilient, but otherwise were not different socioeconomically. High social support pre-adversity and during adversity increased the likelihood of resilience by 40-60% compared with those with low social support. CONCLUSIONS: Resilience is relatively rare and favours older women. It is fostered by high levels of social support existing before exposure to adversity.


Subject(s)
Adaptation, Psychological , Life Change Events , Mental Health , Aged , Educational Status , Female , Humans , Male , Middle Aged , Regression Analysis , Social Class , Social Support , Surveys and Questionnaires , United Kingdom/epidemiology
18.
AJNR Am J Neuroradiol ; 29(8): 1561-3, 2008 Sep.
Article in English | MEDLINE | ID: mdl-18499797

ABSTRACT

Esthesioneuroblastoma (ENB) is a malignant neoplasm of the olfactory epithelium. Metastasis of ENBs to retropharyngeal lymph nodes is an important finding on imaging examinations that alters staging and treatment. A total of 17 cases of ENB from 3 institutions were evaluated. The CT and MR imaging findings from the cases of 4 patients with ENB with retropharyngeal metastatic disease are reviewed. The vector of spread, staging, and treatment implications are discussed.


Subject(s)
Esthesioneuroblastoma, Olfactory/diagnosis , Esthesioneuroblastoma, Olfactory/secondary , Nasal Cavity/diagnostic imaging , Nasal Cavity/pathology , Nose Neoplasms/diagnosis , Pharynx/diagnostic imaging , Pharynx/pathology , Aged , Female , Humans , Lymphatic Metastasis , Magnetic Resonance Imaging , Male , Middle Aged , Tomography, X-Ray Computed
19.
Kidney Int ; 71(12): 1205-14, 2007 Jun.
Article in English | MEDLINE | ID: mdl-17410103

ABSTRACT

Glomerular diseases encompass a broad array of clinicopathologically defined syndromes which together account for 90% of end-stage kidney disease costing $20 billion per annum to treat in the United States alone. Recent insights have defined the central role of the podocyte as both the regulator of glomerular development as well as the determinant of progression to glomerulosclerosis. We can now place all glomerular diseases within this spectrum of podocytopathies with predictable outcomes based on podocyte biology impacted by temporal, genetic, and environmental cues. This simplified construct is particularly useful to rationalize clinical effort toward podocyte preservation and prevention of progression as well as to focus basic research effort on understanding podocyte biology and for clinical research toward development of practical monitoring strategies for podocyte injury, dysfunction, and loss.


Subject(s)
Glomerulonephritis/etiology , Glomerulonephritis/pathology , Kidney Glomerulus/pathology , Podocytes/pathology , Disease Progression , Glomerulonephritis/therapy , Humans , Kidney Glomerulus/growth & development , Podocytes/drug effects , Podocytes/physiology
20.
AJNR Am J Neuroradiol ; 27(10): 2204-9, 2006.
Article in English | MEDLINE | ID: mdl-17110695

ABSTRACT

BACKGROUND AND PURPOSE: Imaging characteristics of temporal bone meningioma have not been previously reported in the literature. CT and MR imaging findings in 13 cases of temporal bone meningioma are reviewed to define specific imaging features. METHODS: A retrospective review of our institutional case archive revealed 13 cases of histologically confirmed temporal bone meningioma. CT and MR imaging studies were reviewed to characterize mass location, vector of spread, bone changes, enhancement characteristics, and intracranial patterns of involvement. Clinical presenting signs and symptoms were correlated with imaging findings. RESULTS: Thirteen temporal bone meningiomas were reviewed in 8 women and 5 men, aged 18-65 years. Meningiomas were stratified into 3 groups on the basis of location and tumor vector of spread. There were 6 tegmen tympani, 5 jugular foramen (JF), and 2 internal auditory canal (IAC) meningiomas. Tegmen tympani and JF meningiomas were characterized by spread to the middle ear cavity. IAC meningiomas, by contrast, spread to the cochlea and vestibule. Hearing loss was the most common clinical presenting feature in all cases of temporal bone meningioma (10/13). The presence of tumor adjacent to the ossicles strongly correlated with conductive hearing loss (7/9). CONCLUSION: Meningioma involving the temporal bone is rare. Three subgroups of meningioma exist in this location: tegmen tympani, JF, and IAC meningioma. Tegmen tympani and JF meningiomas spread to the middle ear cavity. IAC meningiomas spread to intralabyrinthine structures. Conductive hearing loss is commonly seen in these patients and can be surgically correctable.


Subject(s)
Magnetic Resonance Imaging , Meningioma/diagnosis , Skull Neoplasms/diagnosis , Temporal Bone , Tomography, X-Ray Computed , Adolescent , Adult , Female , Humans , Male , Middle Aged , Retrospective Studies
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