Machine learning based urban sprawl assessment using integrated multi-hazard and environmental-economic impact.

The increasing demand for land development due to human activities has fueled urbanization. However, uncontrolled urban development in some regions has resulted in urban environmental problems arising from an imbalance between supply and demand. This study aims to develop an integrated model for evaluating and prioritizing the management of hazardous urban sprawl in the Bandung metropolitan region of Indonesia. The novelty of this study lies in its pioneering application of long-term remote sensing data-based and machine learning techniques to formulate an urban sprawl priority index. This index is unique in its consideration of the impacts stemming from human economic activity, environmental degradation, and multi-disaster levels as integral components. The analysis of hazardous urban sprawl across three distinct time periods (1985-1993, 1993-2008, and 2008-2018) revealed that the 1993-2008 period had the highest increase in human economic activity, reaching 172,776 ha. The 1985-1993 period experienced the highest level of environmental degradation in the study area. Meanwhile, the 1993-2008 period showed the highest concentration of multi-hazard locations. The combined model of hazardous urban sprawl, incorporating the three parameters, indicated that the highest priority for intervention was on the outskirts of urban areas, specifically in West Bandung Regency, Cimahi, Bandung Regency, and East Bandung Regency. Regions with high-priority indices require greater attention from the government to mitigate the negative impacts of hazardous urban sprawl. This model, driven by the urban sprawl priority index, is envisioned to regulate urban movement in a more sustainable manner. Through the efficient monitoring of urban environments, the study seeks to guarantee the preservation of valuable natural resources while promoting sustainable urban development practices.

A computational simulation appraisal of banana lectin as a potential anti-SARS-CoV-2 candidate by targeting the receptor-binding domain.

BACKGROUND: The ongoing concern surrounding coronavirus disease 2019 (COVID-19) primarily stems from continuous mutations in the genome of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), leading to the emergence of numerous variants. The receptor-binding domain (RBD) in the S1 subunit of the S protein of the virus plays a crucial role in recognizing the host's angiotensin-converting enzyme 2 (hACE2) receptor and facilitating cell membrane fusion processes, making it a potential target for preventing viral entrance into cells. This research aimed to determine the potential of banana lectin (BanLec) proteins to inhibit SARS-CoV-2 attachment to host cells by interacting with RBD through computational modeling. MATERIALS AND METHODS: The BanLecs were selected through a sequence analysis process. Subsequently, the genes encoding BanLec proteins were retrieved from the Banana Genome Hub database. The FGENESH online tool was then employed to predict protein sequences, while web-based tools were utilized to assess the physicochemical properties, allergenicity, and toxicity of BanLecs. The RBDs of SARS-CoV-2 were modeled using the SWISS-MODEL in the following step. Molecular docking procedures were conducted with the aid of ClusPro 2.0 and HDOCK web servers. The three-dimensional structures of the docked complexes were visualized using PyMOL. Finally, molecular dynamics simulations were performed to investigate and validate the interactions of the complexes exhibiting the highest interactions, facilitating the simulation of their dynamic properties. RESULTS: The BanLec proteins were successfully modeled based on the RNA sequences from two species of banana (Musa sp.). Moreover, an amino acid modification in the BanLec protein was made to reduce its mitogenicity. Theoretical allergenicity and toxicity predictions were conducted on the BanLecs, which suggested they were likely non-allergenic and contained no discernible toxic domains. Molecular docking analysis demonstrated that both altered and wild-type BanLecs exhibited strong affinity with the RBD of different SARS-CoV-2 variants. Further analysis of the molecular docking results showed that the BanLec proteins interacted with the active site of RBD, particularly the key amino acids residues responsible for RBD's binding to hACE2. Molecular dynamics simulation indicated a stable interaction between the Omicron RBD and BanLec, maintaining a root-mean-square deviation (RMSD) of approximately 0.2 nm for a duration of up to 100 ns. The individual proteins also had stable structural conformations, and the complex demonstrated a favorable binding-free energy (BFE) value. CONCLUSIONS: These results confirm that the BanLec protein is a promising candidate for developing a potential therapeutic agent for combating COVID-19. Furthermore, the results suggest the possibility of BanLec as a broad-spectrum antiviral agent and highlight the need for further studies to examine the protein's safety and effectiveness as a potent antiviral agent.

Spatial integration framework of solar, wind, and hydropower energy potential in Southeast Asia.

Amid its massive increase in energy demand, Southeast Asia has pledged to increase its use of renewable energy by up to 23% by 2025. Geospatial technology approaches that integrate statistical data, spatial models, earth observation satellite data, and climate modeling can be used to conduct strategic analyses for understanding the potential and efficiency of renewable energy development. This study aims to create the first spatial model of its kind in Southeast Asia to develop multi-renewable energy from solar, wind, and hydropower, further broken down into residential and agricultural areas. The novelty of this study is the development of a new priority model for renewable energy development resulting from the integration of area suitability analysis and the estimation of the amount of potential energy. Areas with high potential power estimations for the combination of the three types of energy are mostly located in northern Southeast Asia. Areas close to the equator, have a lower potential than the northern countries, except for southern regions. Solar photovoltaic (PV) plant construction is the most area-intensive type of energy generation among the considered energy sources, requiring 143,901,600 ha (61.71%), followed by wind (39,618,300 ha; 16.98%); a combination of solar PV and wind (37,302,500 ha; 16%); hydro (7,665,200 ha; 3.28%); a combination of hydro and solar PV (3,792,500 ha; 1.62%); and a combination of hydro and wind (582,700 ha; 0.25%). This study is timely and important because it will inform policies and regional strategies for transitioning to renewable energy, with consideration of the different characteristics present in Southeast Asia.

Multi-air pollution risk assessment in Southeast Asia region using integrated remote sensing and socio-economic data products.

Air pollution has massive impacts on human life and poor air quality results in three million deaths annually. Air pollution can result from natural causes, including volcanic eruptions and extreme droughts, or human activities, including motor vehicle emissions, industry, and the burning of farmland and forests. Emission sources emit multiple pollutant types with diverse characteristics and impacts. However, there has been little research on the risk of multiple air pollutants; thus, it is difficult to identify multi-pollutant mitigation processes, particularly in Southeast Asia, where air pollution moves dynamically across national borders. In this study, the main objective was to develop a multi-air pollution risk index product for CO, NO2, and SO2 based on Sentinel-5P remote sensing data from 2019 to 2020. The risk index was developed by integrating hazard, vulnerability, and exposure analyses. Hazard analysis considers air pollution data from remote sensing, vulnerability analysis considers the air pollution sources, and exposure analysis considers the population density. The novelty of this study lies in its development of a multi-risk model that considers the weights obtained from the relationship between the hazard and vulnerability parameters. The highest air pollution risk index values were observed in urban areas, with a high exposure index that originates from pollution caused by human activity. Multi-risk analysis of the three air pollutants revealed that Singapore, Vietnam, and the Philippines had the largest percentages of high-risk areas, while Indonesia had the largest total high-risk area (4361 km2). Using the findings of this study, the patterns and characteristics of the risk distribution of multiple air pollutants in Southeast Asia can be identified, which can be used to mitigate multi-pollutant sources, particularly with respect to supporting the clean air targets in the Sustainable Development Goals.

A 50-m forest cover map in Southeast Asia from ALOS/PALSAR and its application on forest fragmentation assessment.

Southeast Asia experienced higher rates of deforestation than other continents in the 1990s and still was a hotspot of forest change in the 2000s. Biodiversity conservation planning and accurate estimation of forest carbon fluxes and pools need more accurate information about forest area, spatial distribution and fragmentation. However, the recent forest maps of Southeast Asia were generated from optical images at spatial resolutions of several hundreds of meters, and they do not capture well the exceptionally complex and dynamic environments in Southeast Asia. The forest area estimates from those maps vary substantially, ranging from 1.73×10(6) km(2) (GlobCover) to 2.69×10(6) km(2) (MCD12Q1) in 2009; and their uncertainty is constrained by frequent cloud cover and coarse spatial resolution. Recently, cloud-free imagery from the Phased Array Type L-band Synthetic Aperture Radar (PALSAR) onboard the Advanced Land Observing Satellite (ALOS) became available. We used the PALSAR 50-m orthorectified mosaic imagery in 2009 to generate a forest cover map of Southeast Asia at 50-m spatial resolution. The validation, using ground-reference data collected from the Geo-Referenced Field Photo Library and high-resolution images in Google Earth, showed that our forest map has a reasonably high accuracy (producer's accuracy 86% and user's accuracy 93%). The PALSAR-based forest area estimates in 2009 are significantly correlated with those from GlobCover and MCD12Q1 at national and subnational scales but differ in some regions at the pixel scale due to different spatial resolutions, forest definitions, and algorithms. The resultant 50-m forest map was used to quantify forest fragmentation and it revealed substantial details of forest fragmentation. This new 50-m map of tropical forests could serve as a baseline map for forest resource inventory, deforestation monitoring, reducing emissions from deforestation and forest degradation (REDD+) implementation, and biodiversity.