1.
J Helminthol
; 51(2): 115-9, 1977 Jun.
Article
in English
| MEDLINE
| ID: mdl-886176
ABSTRACT
Praziquantel (Droncit) is a new anthelminthic agent with a strikingly wide therapeutic index. The efficiency of the drug against Diphyllobothrium latum was tested in vivo and in vitro. With a drug dose of 50 mg/kg, artificially infected hamsters were completely cured. The threshold value of the active dose was between 2-5 and 10-0 mg/kg. Clinical trials with Praziquantel against human diphyllobothriasis show great promise, all of ten patients treated with 25-0 mg/kg of the drug being cured. Praziquantel had little effect on larval or adult diphyllobothriids in vitro.
Subject(s)
Anticestodal Agents/therapeutic use , Diphyllobothriasis/drug therapy , Isoquinolines/therapeutic use , Animals , Anticestodal Agents/pharmacology , Cricetinae , Diphyllobothrium/drug effects , Humans , Isoquinolines/pharmacology , Mesocricetus
2.
Bol Chil Parasitol
; 32(1-2): 7-10, 1977.
Article
in Spanish
| MEDLINE
| ID: mdl-911437