ABSTRACT
Aim: Obtain clinical consensus on factors impacting first-line prescribing for transplant-ineligible (TIE) patients with newly diagnosed multiple myeloma (NDMM). Materials & methods: A double-blinded, modified Delphi panel was employed. USA-based hematologists/oncologists who treat TIE patients with NDMM were selected as expert panelists. Results: Consensus was reached that patient frailty, performance status, comorbidities, treatment efficacy, and adverse event profile affect first-line prescribing. All panelists agreed it is important to use the most efficacious treatment first; 88% of panelists considered daratumumab-containing regimens the most efficacious. Panelists agreed treatment should be continued until progression while benefits outweigh risk. Conclusion: Findings reinforce the importance of using the most efficacious regimen upfront for TIE NDMM, and nearly all panelists considered daratumumab-containing regimens the most efficacious treatment.
The purpose of this study was to determine the latest clinician preferences and opinions on factors affecting initial treatment selection for people recently diagnosed with multiple myeloma and unable to receive a bone marrow transplant, and to understand challenges with current treatments used in clinical practice. A panel of doctors with an average of two decades of experience treating blood disorders and cancers were recruited as expert panelists. Experts discussed treatment options by completing two rounds of surveys on treatment and one round of discussion. All experts agreed that the most effective treatment should be used first. Most experts considered treatment containing the drug daratumumab to be the most effective. Experts agreed that treatment should be continued until the cancer worsens if the treatment offers more benefits than side effects.
ABSTRACT
The COVID-19 pandemic has caused significant disruptions to healthcare, including reduced administration of routinely recommended HPV vaccines in a number of European countries. Because the extent and trends of accumulated vaccine dose deficits may vary by country, decision-makers need country-specific information regarding vaccine deficits to plan effective catch-up initiatives. To address this knowledge gap in Switzerland and Greece, this study used a previously published COVID-19 recovery calculator and historical vaccine sales data to quantify the cumulative number of missed doses and the catch-up rate required to clear the deficit in Switzerland and Greece. The resultant cumulative deficit in HPV doses for Switzerland and Greece were 24.4% and 21.7%, respectively, of the total number of doses disseminated in 2019. To clear the dose deficit by December 2025, monthly vaccination rates must be increased by 6.3% and 6.0% compared to 2019 rates in Switzerland and Greece, respectively. This study demonstrates that administration rates of routine HPV vaccines decreased significantly among Swiss and Greek adolescents during the COVID-19 pandemic and that a sustained increase in vaccination rates is necessary to recover the HPV dose deficits identified and to prevent long-term public health consequences.
ABSTRACT
Eyewitnesses to a crime rely heavily on their visual memory; however, there are many ways that the details of visual scenes can be missed, or distorted. In particular, for emotional scenes, the "boundaries" are narrowed at retrieval, whereas central details-such as a weapon-are remembered in greater detail. This phenomenon is known as boundary restriction, the reverse of boundary extension whereby people tend to expand the boundaries of a neutral scene at retrieval. In the present series of experiments, we investigated whether arousal is the element of an emotional scene that leads to increased boundary restriction or reduced boundary extension. We presented neutral images to participants either with or without a stress-inducing noise. In Experiment 1a and 1b, at test, participants viewed the image they originally viewed next to the same image but with narrower or wider boundaries and selected which of the two images they originally viewed. In Experiment 2, at test, participants viewed the identical image they originally viewed, but were told the boundaries had been changed. Participants selected the extent to which the images at test had restricted or extended boundaries compared to their memory of the original image. When the noise stressor was present, participants made more boundary restriction errors-selecting the image with narrower boundaries than the original-and fewer boundary extension errors than when the noise was absent. Our data suggest that arousal plays a key role in boundary judgements.
