Effects of Eccentric Speed during Front Squat Conditioning Activity on Post-activation Performance Enhancement of Hip and Thigh Muscles.

The phenomenon of post-activation performance enhancement plays an unidentified role in movement eccentric speed and individual muscle group responses. Therefore, this study aimed to determine whether the loaded front squat (FSq) speed of the eccentric phase would influence the post-activation performance enhancement effect and whether the FSq would elicit similar performance enhancement of knee flexion, knee extension, hip flexion, and hip extension muscles. Twenty resistance-trained handball players performed the FSq under maximum eccentric-concentric speed and 2-s eccentric speed (only the eccentric phase performed), while pre- and post-front squat countermovement jump, knee, and hip isokinetic flexion/extension performance were tested. The FSq conditioning activity was performed in a single set of three repetitions with either 90% (maximum eccentric-concentric speed) or 120% (2-s eccentric speed) of one repetition maximum, and post-performance was measured 4-12 min after the FSq. Athletes randomly changed the FSq eccentric speed and tested the hip or knee isokinetic flexion/extension strength at 180°/s. ANOVA showed that the rate of force development during the jump increased (Cohen d = 0.59-0.77) with no differences between 2-s eccentric and maximum speed eccentric protocols. Isokinetic strength increased after the 2-s eccentric FSq in hip extension (d = 0.76-0.86), knee flexion (d = 0.74-0.88), and hip flexion (d = 0.82), with no differences in knee extension strength. After maximum eccentric-concentric speed, isokinetic strength increased in hip extension (d = 1.25). In conclusion, the FSq conditioning activity enhances hip extensors' performance more than knee extensors' performance. Different eccentric types of muscle action during a conditioning activity alter the level of local muscle enhancement.

Fatigue and Metabolic Responses during Repeated Sets of Bench Press Exercise to Exhaustion at Different Ranges of Motion.

This study compared the acute effects of different ranges of motion (ROM) on fatigue and metabolic responses during repeated sets of bench press exercise. Ten resistance trained men performed three sets to momentary failure with two-min rest intervals at three different ROM: full ROM (FULL), and partial ROM in which the barbell was moved either at the bottom half (BOTTOM) or the top half (TOP) of the full barbell vertical displacement. In TOP, a higher load was lifted, and a higher total number of repetitions was performed compared to FULL and BOTTOM (130 ± 17.6 vs. 102.5 ± 15.9 vs. 98.8 ± 17.5 kg; 55.2 ± 9.8, 32.2 ± 6.5 vs. 49.1 ± 16.5 kg, respectively p < 0.01). Work per repetition was higher in FULL than TOP and BOTTOM (283 ± 43 vs. 205 ± 32 vs. 164 ± 31 J/repetition, p < 0.01). Mean barbell velocity at the start of set 1 was 21.7% and 12.8% higher in FULL compared to TOP and BOTTOM, respectively. The rate of decline in mean barbell velocity was doubled from set 1 to set 3 (p < 0.01) and was higher in FULL than both TOP and BOTTOM (p < 0.001). Also, the rate of mean barbell velocity decline was higher in BOTTOM compared to TOP (p = 0.045). Blood lactate concentration was similarly increased in all ROM (p < 0.001). Training at TOP ROM allowed not only to lift a higher load, but also to perform more repetitions with a lower rate of decline in mean barbell velocity. Despite the lower absolute load and work per repetition, fatigue was higher in BOTTOM than TOP and this may be attributed to differences in muscle length.

The Impact of Range of Motion on Applied Force Characteristics and Electromyographic Activity during Repeated Sets of Bench Press Exercise.

This study examined the effects of range of motion (ROM) on applied force, power output and surface electromyographic (sEMG) responses during repeated sets of bench press exercise executed as fast as possible. Ten resistance trained men performed three sets to momentary failure with two-min rest intervals under three different ROM conditions: (a) full ROM (FULL), (b) TOP, at the top half of ROM, and (c) BOTTOM, at the bottom half of ROM. Mean and peak force were higher in TOP compared to FULL and BOTTOM (mean force: 817 ± 80 vs. 657 ± 98 vs. 623 ± 122 N, respectively, p < 0.001) with no differences between FULL and BOTTOM. During repeated sets, large decreases were found in peak (by 29.4 to 45.3%) and mean power (by 55.5 to 64.7%) from the first to the last repetitions. However, the decrease in mean force was only 2% (p < 0.01) and decreases in peak force ranged from 6.7 and 8.8% to zero, indicating the velocity loss was the main contributor to fatigue in power output. Although force and power output in set 3 were unchanged in BOTTOM, mean power output decreased significantly, suggesting that lower performance and fatigue may be related to the longer muscle length. Fatigue was accompanied by an increase in sEMG activity and a decrease in median frequency in all muscles, with triceps brachialis sEMG reflecting more the force and power differences among ROMs. In conclusion, fatigue depends on velocity rather than force loss during bench press exercise at different ROMs.

The effect of complex contrast training with different training frequency on the physical performance of youth soccer players: a randomized study.

Background: Complex contrast training (CCT) is potentially an efficient method to improve physical abilities such as muscle strength, power output, speed, agility, are extremely important in developing soccer players of different age categories. Aim: This study aimed to analyze the effects of 6 weeks of CCT program applied in different training frequency (sessions per week) on youth soccer players performance. Methods: Twenty-one youth soccer players (age: 15.3 ± 1.1 years; body mass 64.9 ± 0.7 kg; height 175.4 ± 0.7 cm) were randomized into three groups: a regular pre-season training control group (G0, n = 8), a group with regular pre-season training plus twice-a-week CCT (G2, n = 6), and a group with regular pre-season training plus thrice-a-week CCT (G3, n = 7). The CCT consisted of soccer skills-based exercises distributed across five stations, to be performed before common regular practice during a 6-week pre-season period. The agility (505 Agility test), sprint (S5 and S15), jump (SJ and CMJ), and free kick speed (11 m from the goal) of the groups were analyzed pre- and post-CCT intervention. During a 6-week pre-season period, the players integrated CCT into their regular training sessions. Furthermore, performance variables were compared between the groups. Results: A statistical difference was identified for the timepoint for the players' CMJ (p = 0.023; η2 = 0.343) and the free kick speed (p = 0.013; η2 = 0.383) using ANOVA. The G3 showed a significant improvement in the CMJ (p = 0.001) and the free kick speed (p = 0.003) between pre- to post-CCT test. No other significant changes in performance were observed (p > 0.05). Conclusion: The CCT training program with a weekly frequency of 3 days per week is effective in improving free kick speed and CMJ performance in young male soccer players (U-15 and U-17 categories). CCT training programs have the potential to refine an athlete's preparation for competition. However, certain performance tests did not demonstrate substantial enhancements. Consequently, additional investigations are required to ascertain the effectiveness of CCT.

High-Intensity Conditioning Activity Causes Localized Postactivation Performance Enhancement and Nonlocalized Performance Reduction.

ABSTRACT: Kolinger D, Stastny P, Pisz A, Krzysztofik M, Wilk M, Tsoukos A, and Bogdanis GC. High-intensity conditioning activity causes localized postactivation performance enhancement and nonlocalized performance reduction. J Strength Cond Res 38(1): e1-e7, 2024-This study aimed to examine whether a conditioning activity (CA) performed by the legs (barbell back squat) may cause postactivation performance enhancement (PAPE) on muscle groups other than leg extensors in isokinetic (eccentric [ECC] and concentric [CON]) and dynamic movement. Twelve male basketball players (age: 21.3 ± 3.2, body mass: 89.6 ± 14.1 kg, height: 187.4 ± 4.6 cm, and 1 repetition maximum (1RM) barbell back squat: 113 ± 21 kg) with previous resistance-training experience of at least 2 years, performed 3 sets of 3-4 repetitions of back-squats with submaximal load (60, 90, and 90% 1RM) as CA. Before and after the CA, they performed pretest and post-test in the form of countermovement jumps (CMJs) (localized) or explosive push-ups (EPUs) (nonlocalized) along with isokinetic flexion and extension at the knee (localized) or at the elbow (nonlocalized). The localized and nonlocalized protocols were divided into 2 days in a randomized order. The back squat as CA significantly increased peak torque (PT) (p < 0.05) in all CON and ECC muscle actions and average power per repetition (APPR) (p < 0.05) (all muscle actions except ECC flexion) of the localized isokinetic tests with large (>0.8) and medium (0.4-0.79) effect sizes and significantly decreased (p < 0.01) the PT and APPR (p < 0.01) of the nonlocalized isokinetic test in the ECC flexion. The CMJ and EPU tests showed no significant differences (p > 0.05) between premeasures and postmeasures of take-off height. The effect of PAPE seems to be specific to the muscles most involved in the CA, and the CA inhibits PT of subsequent muscle ECC contractions in muscles not involved in the CA.

Reduction of leptin levels during acute exercise is dependent on fasting but not on caloric restriction during chronic exercise: A systematic review and meta-analysis.

BACKGROUND: The importance of leptin in controlling body mass has recently gained more attention. Its levels are directly associated with the amount of fat mass, but not necessarily dependent on it. Exercise has great potential in reducing leptin levels, however the response of exercise to this cytokine is still not well understood. OBJECTIVE: The objective of the review was to analyze the effects of physical exercise on plasma leptin concentration, either acutely (post-exercise/training session) and/or after a training period (short- or long-term), as well as to investigate the existence of possible moderating variables. METHODS: The studies included in this systematic review were published between 2005 and May 2023. Only peer-reviewed studies, available in English, performed with humans that evaluated the effects of any form of exercise on leptin levels were included. The search was conducted on May 03, 2023, in Embase (Elsevier), MEDLINE via PubMed®, and Web of Science (Core collection). The risk of bias in the included trials was assessed by the Physiotherapy Evidence Database tool, considering 11 questions regarding the methodology of each study with 10 questions being scored. The data (n, mean, and standard deviation) were extracted from included studies to perform random effects meta-analyses using standardized mean difference between the pre- and post-intervention effects. RESULTS: Twenty-five studies (acute effect: 262 subjects; short- and long-term effect: 377 subjects) were included in this systematic review and meta-analysis. Short- and long-term physical exercise and caloric restriction plus exercise reduce plasma leptin levels, presenting statistically significant differences (p<0.001); as well as acute effect (p = 0.035), however the latter result was influenced by the pre-exercise meal as shown in the subgroup analysis. In this meta-analysis the effect of moderating factors on leptin reduction, not addressed by past reviews, is verified, such as the relationship with caloric restriction, exercise intensity and pre-exercise meal on acute responses. CONCLUSION: Both acute and chronic exercise reduce leptin levels, yet the acute effect is dependent on the pre-exercise meal. In addition to having a long-term reduction in leptin levels, the minimum amount of weekly exercise to have a significant reduction in plasma leptin is 180 minutes of moderate-intensity exercise and 120 minutes of high-intensity exercise.

Effects of blood flow restriction on mechanical properties of the rectus femoris muscle at rest.

Introduction: This study examined the effects of blood flow restriction (BFR) and reperfusion on the mechanical properties of the rectus femoris muscle at rest (frequency and stiffness). Methods: Fourteen trained men (body weight = 81.0 ± 10.3 kg; BMI = 25 ± 3.0 m/kg2; height = 181 ± 4 cm; training experience = 6.0 ± 2.2 years) participated in an experimental session involving their dominant (BFR) and non-dominant leg (control). Muscle mechanical properties were measured using Myoton's accelerometer at the midpoint of the rectus femoris muscle at five time points. In the BFR leg, an 80% arterial occlusion pressure was applied by a cuff for 5 min. No cuff was applied in the control leg. Femoral Myoton measurements were taken from both legs 2 and 4 min after the start of BRF as well as 30 s and 2 min after the end of the occlusion period. Results: The two-way ANOVA revealed a statistically significant interaction effect for stiffness and frequency (p < 0.001; η2 > 0.67). The post hoc analysis showed that both stiffness and frequency increased during BFR compared with rest and then dropped to the resting levels post BFR period. Also, stiffness and frequency were higher than control only during the BFR period, and similar during rest and post BFR. Conclusion: These results indicate that the application of BFR at rest leads to significant changes in mechanical properties of the rectus femoris muscle.

Acute Effects of Supra- and High-Loaded Front Squats on Mechanical Properties of Lower-Limb Muscles.

Knowledge about the acute effects of supramaximal-loaded resistance exercises on muscle mechanical properties is scarce. Therefore, this study aimed to examine changes in dominant limb biceps femoris and vastus lateralis oscillation frequency and stiffness before and after high- and supramaximal-loaded front squats. Nineteen male handball players participated in the experimental session with a barbell front squat 1RM. The first set was performed at 70% of the 1RM for four repetitions, and the second and third sets were performed at 90%1RM in an eccentric-concentric or an eccentric-only manner at 120% of the 1RM for three repetitions. The handheld myometer was used for the measurement of the biceps femoris and vastus lateralis stiffness and the oscillation frequency of the dominant limb 5 min before and at the 5th and 10th min after front squats. A two-way ANOVA neither indicated a statistically significant interaction (p = 0.335; η2 = 0.059 and p = 0.103; η2 = 0.118), the main effect of a condition (p = 0.124; η2 = 0.126 and p = 0.197; η2 = 0.091), nor the main effect of the time point (p = 0.314; η2 = 0.06 and p = 0.196; η2 = 0.089) for vastus lateralis and biceps femoris stiffness. However, there was a statistically significant interaction (F = 3.516; p = 0.04; η2 = 0.163) for vastus lateralis oscillation frequency. The post hoc analysis showed a significantly higher vastus lateralis oscillation frequency at POST (p = 0.037; d = 0.29) and POST_10 (p = 0.02; d = 0.29) compared to PRE during the SUPRA condition. Moreover, Friedman's test indicated statistically significant differences in biceps femoris oscillation frequency (test = 15.482; p = 0.008; Kendall's W = 0.163). Pairwise comparison showed a significantly lower biceps femoris oscillation frequency in POST (p = 0.042; d = 0.31) and POST_10 (p = 0.015; d = 0.2) during the HIGH condition compared to that in the corresponding time points during the SUPRA condition. The results of this study indicate that the SUPRA front squats, compared to the high-loaded ones, cause a significant increase in biceps femoris and vastus lateralis oscillation frequency.

Acute Effects of High-Load vs. Plyometric Conditioning Activity on Jumping Performance and the Muscle-Tendon Mechanical Properties.

ABSTRACT: Krzysztofik, M, Wilk, M, Pisz, A, Kolinger, D, Bichowska, M, Zajac, A, and Stastny, P. Acute effects of high-load versus plyometric conditioning activity on jumping performance and the muscle-tendon mechanical properties. J Strength Cond Res 37(7): 1397-1403, 2023-The effectiveness of high-load and plyometric exercises as conditioning activity (CA) is not well described in the level of performance enhancement and muscle-tendon properties. Therefore, this study aimed to compare the effectiveness of high-loaded back squats and body mass tuck jumps among amateur soccer players on the height of countermovement jump performed without (CMJ) and with arm swing (CMJa) and to verify the usefulness of the myotonometry in assessing the level of CA-induced fatigue. Therefore, 16 male amateur soccer players (resistance training experience: 2 ± 1 year, relative 1 repetition maximum back squat strength: 1.41 ± 0.12 kg·body mass-1) performed 3 experimental sessions to compare the acute effects of 3 sets of 3 repetitions at 85% one repetition maximum of half back squats (HL), 3 sets of 5 repetitions of tuck jump exercises (PLY), and no CA (CTRL) on CMJ and CMJa height. Moreover, the gastrocnemius medialis and Achilles tendon tone and stiffness were examined. Measurements were performed 5 minutes before CA and in the third, sixth, and ninth minutes after CA. The CMJ height significantly increased from pre-CA to post-CA in the CTRL (p = 0.005; effect size [ES] = 0.36; Δ = +3.4%) and PLY (p = 0.001; ES = 0.83; Δ = +8.8%) conditions. Moreover, post-CA jump height was significantly higher in PLY than in the HL condition (p = 0.024; ES = 0.6; Δ = +5.9%). No significant differences were found for CMJa height, tone, and stiffness of gastrocnemius medialis and Achilles tendon. The low-volume plyometric CA (i.e., 3 sets of 5 repetitions) is recommended instead of high-loaded CA (≥85% one repetition maximum) for amateur athletes. In addition, it has been established that the performance improvement was independent of changes in the mechanical properties of the gastrocnemius medialis and Achilles tendon. Furthermore, it seems that the complexity of the post-CA task may affect the magnitude of the postactivation performance enhancement.

The effects of ischemia during rest intervals on strength endurance performance.

BACKGROUND: The study aimed to evaluate the effects of ischemia used during the rest periods between successive sets on maximal number of performed repetitions, time under tension and bar velocity during the bench press exercise. METHODS AND MATERIALS: Thirteen healthy resistance trained men volunteered for the study (age = 28.5 ± 7.1 years; body mass = 87.2 ± 8.6 kg; bench press 1RM = 143.1 ± 20.7 kg; training experience = 11.0 ± 6.9 years). In experimental protocol the subjects performed 5 sets of bench press exercise at 70%1RM with maximal number of repetitions in each and with 5 minutes rest periods between each set. During the ischemia condition occlusion with 80% arterial occlusion pressure (AOP) was applied using a 10 cm wide cuff, before the first set of the bench press exercise and during all rest periods between sets (for 4.5 minute). During the control condition no ischemia was applied. RESULTS: The two-way repeated measures ANOVA showed a statistically significant interaction effect for time under tension (p = 0.022; η2 = 0.20). However, the results did not show a statistically significant interaction effect for peak bar velocity (p = 0.28; η2 = 0.10) mean bar velocity (p = 0.38; η2 = 0.08), and for number of performed repetitions (p = 0.28; η2 = 0.09). The post hoc analysis for interaction showed significantly shorter time under tension for ischemia condition compared to control in set 1 (p < 0.01). The post hoc analysis for main effect of condition revealed that time under tension was significantly shorter for ischemia compared to control condition (p = 0.04). CONCLUSION: The results of this study indicate that ischemia intra-conditioning does not increase strength-endurance performance as well as bar velocity during bench press exercise performed to muscle failure.

Real-life data of abiraterone acetate and enzalutamide treatment in post-chemotherapy metastatic castration-resistant prostate cancer in Poland.

Background: Abiraterone acetate (ABI) and Enzalutamide (ENZA) are second-generation hormone drugs that show breakthrough activity in post-chemotherapy, metastatic castration-resistant prostate cancer (mCRPC). The leading oncological and urological guidelines indicate both drugs with the same strong recommendation. There is a lack of randomized trials which compare the efficacy of ABI and ENZA. The current study aimed to compare the effectiveness of the drugs with an analysis of prognostic factors related to those drugs. Patients and methods: The study included 420 patients with docetaxel (DXL) pretreated mCRPC from seven Polish cancer centers. Patients were treated according to inclusion and exclusion criteria in the Polish national drug program (1000 mg ABI and 10 mg prednisone, n=76.2%; ENZA, 160 mg; n=23.8%). The study retrospectively analyzed the overall survival (OS), time to treatment failure (TTF), PSA 50% decline rate (PSA 50%) and selected clinic-pathological data. Results: In the study group, the median OS was 17 months (95% CI: 15.6-18.3). The median OS (26.1 vs. 15.7 mo.; p<0.001), TTF (14.2 vs. 7.6 mo.; p<0.001) and PSA 50% (87.5 vs. 56%; p<0.001) were higher in ENZA than in ABI treatment. Multivariate analysis shows that ENZA treatment and PSA nadir <17.35 ng/mL during or after DXL treatment were related to longer TTF. ENZA treatment, DXL dose ≥750 mg, PSA nadir <17.35 ng/mL during or after DXL treatment was related to longer OS. Conclusions: ENZA treatment may be related to more favorable oncological outcomes than ABI treatment in the studied Polish population of patients. A 50% decline in PSA is an indicator of longer TTF and OS. Due to the non-randomized and retrospective nature of the analysis, the current results require prospective validation.

Cardiovascular and Perceptual Responses to Resistance Training with Practical Blood Flow Restriction Induced by a Non-Elastic Band vs. Pneumatic Cuff: A Crossover Randomized Study.

Our purpose in this study was to analyze perceptual and cardiovascular responses in low-load resistance training (RT) sessions associated with a fixed non-elastic band compressed to the proximal region of the arms (p-BFR) versus a pneumatic cuff inflated to a pressure of 150 mmHg (t-BFR). Participants (16 healthy trained men) were randomly assigned to two conditions of low-load RT (20% one repetition maximum [1RM]) with BFR (p-BFR or t-BFR). In both conditions, the participants performed five exercises (4 sets/30-15-15-15) for the upper-limbs, but in one of the conditions, the exercises were performed with a p-BFR induced by a non-elastic band, while in the other, the exercises were performed with a t-BFR using a device with similar width. The devices used to generate the BFR had similar widths (5 cm). Brachial blood pressure (bBP) and heart rate (HR) were measured before, after each exercise and after the experimental session (5-, 10-, 15-, and 20 min post-session). Rating of perceived exertion (RPE) and rating of pain perception (RPP) were reported after each exercise and 15 minutes post-session. HR increased during the training session in both conditions, with no differences between p-BFR and t-BFR. Neither intervention increased diastolic BP (DBP) during training, but there was a significant post-session reduction in DBP in the p-BFR, with no differences observed between conditions. There were no significant differences in RPE and RPP in the two training conditions, with both conditions associated with higher RPE and RPP at the end versus beginning of the experimental session. We conclude that when BFR device width and material are similar, low-load training with t-BFR and p-BFR promotes similar acute perceptual and cardiovascular responses in healthy trained men.

Acute Effects of Isometric Conditioning Activity on the Viscoelastic Properties of Muscles and Sprint and Jumping Performance in Handball Players.

ABSTRACT: Krzysztofik, M, Spieszny, M, Trybulski, R, Wilk, M, Pisz, A, Kolinger, D, Filip-Stachnik, A, and Stastny, P. Acute effects of isometric conditioning activity on the viscoelastic properties of muscles and sprint and jumping performance in handball players. J Strength Cond Res 37(7): 1486-1494, 2023-The effects of conditioning activity (CA) on muscle stiffness are currently unknown, suggesting that maximum CA effort can increase or decrease the stiffness of involved muscle groups. Therefore, this study aimed to investigate the effect of maximal isometric half-squats on the viscoelastic properties of muscles and postactivation performance enhancement (PAPE) in sprints and jumps. Twelve handball players underwent a standard warm-up and baseline assessment of muscle stiffness and tone of vastus lateralis and gastrocnemius medialis muscle, followed by 20-m sprint with intermediate measures at 5 and 10 m and countermovement jump. The PAPE was assessed by repeating the tests (at 4th, 8th, and 12th minute post-CA) after a CA protocol consisting of 3 sets of 3-second maximal isometric half-squats (EXP) or a control condition (CTRL) without any CA. The vastus lateralis stiffness in the 4th and 12th minute and muscle tone in the 4th minute post-CA significantly decreased compared with baseline ( p = 0.041, ES = 0.57; p = 0.013, ES = 0.52; p = 0.004, ES = 0.81, respectively) in the EXP condition. The 20-m sprint time significantly decreased at all post-CA time points compared with the baseline for the EXP condition ( p < 0.033) and the after values in the CTRL condition ( p < 0.036). In comparison to baseline, the 10-m sprint time decreased in the eighth minute post-CA ( p = 0.021; ES = 0.82) in the EXP condition. Moreover, it was significantly lower at the 8th and 12th minute post-CA ( p = 0.038; ES = 0.71 and p = 0.005; ES = 1.26) compared with that time points in the CTRL condition. The maximal isometric half-squats effectively improved sprint performance and significantly decreased vastus lateralis tone and stiffness. These findings offer new insights into the assessment of viscoelastic properties for evaluating the fatigue or potentiation state, which requires further investigation.

Acute Effects of Varied Back Squat Activation Protocols on Muscle-Tendon Stiffness and Jumping Performance.

ABSTRACT: Krzysztofik, M, Wilk, M, Pisz, A, Kolinger, D, Tsoukos, A, Zajac, A, Stastny, P, and Bogdanis, GC. Acute effects of varied back squat activation protocols on muscle-tendon stiffness and jumping performance. J Strength Cond Res 37(7): 1419-1427, 2023-Intensity, movement velocity, and volume are the principal factors to successfully use postactivation performance enhancement. Therefore, 15 resistance-trained volleyball players completed 3 different back squat configurations as a conditioning activity (CA) in randomized order: (a) 3 sets of 3 repetitions at 85% 1RM (HL); (b) a single set of back squats at 60% 1RM until 10% mean velocity loss (VB); (c) and 2 sets of back squats at 60% 1RM until 10% mean velocity loss (2VB) on subsequent countermovement jump performance, Achilles tendon, and vastus lateralis stiffness with concomitant front thigh skin surface temperature assessment. The measurements were performed 5 minutes before the CA and at 2, 4, 6, 8, and 10 minutes. The jump height was significantly increased in the second minute and at peak, post-CA compared with baseline for all conditions ( p = 0.049; ES = 0.23 and p < 0.001; ES = 0.37). Skin surface temperature was significantly increased for all post-CA time points compared with baseline in the 2VB condition ( p from <0.001-0.023; ES = 0.39-1.04) and in the fourth minute and at peak post-CA in HL condition ( p = 0.023; ES = 0.69 and p = 0.04; ES = 0.46), whereas for the VB condition, a significant decrease in peak post-CA was found ( p = 0.004; ES = -0.54). Achilles tendon stiffness was significantly decreased for second, fourth, eighth, 10th, and peak post-CA in comparison to baseline for all conditions ( p from p = 0.004-0.038; ES = -0.47 to -0.69). Vastus lateralis stiffness was significantly decreased for peak post-CA compared with baseline for all conditions ( p = 0.017; ES = -0.42). We recommend using a single set of barbell squats with a 10% velocity loss as a mechanism of fatigue control to acutely improve jump height performance and avoid unnecessary increases in training volume.

Effects of Unilateral Conditioning Activity on Acute Performance Enhancement: A Systematic Review.

This review aimed to summarize the reported effects of unilateral conditioning activity (CA) on unilateral performance, bilateral performance, and the contribution of activated body limb to bilateral performance. A systematic search on MEDLINE, SPORTDiscus, Scopus, and Google Scholar was conducted on February 2022. Twenty-three studies met the inclusion criteria. Throwing, jumping, swimming, change of direction, and isokinetic performance were used as outcome measures to assess the impact of unilateral CAs on inducing post-activation performance enhancement. Eleven studies examined the effectiveness of resistance exercises as a CA, seven investigated plyometric exercises, and five used isokinetic muscle actions as CAs. Notably, only three studies directly compared the effects of bilateral and unilateral CA, and no study reported possible changes in the contribution of each limb during bilateral exercises executed following unilateral CA. Split squats were the most often studied CA (7), and it was shown that multiple sets of high-loaded split squats (85% one-repetition maximum) executed as CA, improve vertical jumping and change of direction after 4 to 8 min of recovery. At the same time, multiple sets of alternate leg bounds performed with ~10% body weight or without any external load result in an improvement of sprint performance, 2 and 8 min later, with the effect being greater when loaded jumps are used. The unilateral CAs such as split squats, alternate leg bounds, and drop jumps can be effectively used to acutely improve a wide variety of athletic tasks, including jumping, sprinting, change of direction, and swimming performance.

Acute Effects of Percussive Massage Treatment on Drop Jump Performance and Achilles Tendon Stiffness.

This study aimed to investigate the impact of Achilles tendon (AT) mechanical percussion massage (PM) on the passive stiffness of that tendon and subsequent drop jump kinematics. Eleven physically active participants performed two conditions in random order: (i) 60 s of PM applied to each AT (EXP) and (ii) no PM (CTRL). Measurements were performed 5 min before, immediately after, and 5 min following the completion of the PM. In the CTRL, measurements were performed at the same time point but no massage was applied. The two-way ANOVA indicated that there was no statistically significant interaction effect on contact time (p = 0.786), reactive strength index (p = 0.914), and relative peak power (p = 0.896). However, a statistically significant interaction on peak velocity (p = 0.046) and jump height (p = 0.03) was found. Despite that, there was no significant post-hoc comparisons for jump height, it slightly decreased 5 min post-PM (p = 0.136; ES = -0.25; Δ = -3.1%) compared with the CTRL condition (p = 1.00; ES = 0.11; Δ = +1.5%). Friedman's test did not show significant differences in dominant (p = 0.073) and non-dominant limb (p = 0.091) AT stiffness. Although not significant, numerically, the dominant limb AT (p = 0.126; ES = -0.64; Δ = -7.8%) had a larger reduction in stiffness immediately post-PM compared with the non-dominant limb (p = 0.294; ES = -0.26; Δ = -3.6%). The results of this study indicated the temporary effect of PM on the reduction in tissue stiffness. Moreover, these findings show that a mechanical PM might slightly hinder subsequent explosive athletic performance.

Cardiac Biomarkers and Geriatric Assessment in Metastatic Castrate-Resistant Prostate Cancer During Abiraterone Acetate Therapy - A Cardio-Oncology Study.

BACKGROUND: Abiraterone acetate (AA) is a drug used in advanced prostate cancer. However, known clinical factors with predictive and prognostic value are scarce. This study evaluated cardiovascular (CV) factors and geriatric scales as potential markers of superior response during AA therapy. METHODS: This is a prospective observational study. Serum levels of high sensitivity troponin T (hsTnT), D-dimer, NT-proBNP and left ventricle ejection fraction (LVEF) were used for CV evaluation. Questionnaires of G8, VES-13, Activities of Daily Living (ADL), Instrumental Activities of Daily Living (iADL), and Geriatric Depression Scale (GDS) were included in the geriatric screening assessment. All measures were taken before AA initiation. Survival curves and Cox proportional hazard models (univariate and multivariate) were used to determine the predictors for a longer time to treatment failure (TTF). RESULTS: Forty nine patients were included in the study. Overall median TTF was 7.9 months (95% CI: 5.9-12.4). In univariate analysis, factors associated with inferior TTF were (P-value < .05): visceral metastases - HR 2.34; 95% CI: 1.24-4.45, history of coronary artery disease - HR 3.02; 95% CI: 1.19-7.66; LVEF < 50% - HR 2.53; 95% CI: 1.03-6.17; P = .041; age-adjusted D-dimer > upper reference limit (URL) - HR 3.53; 95% CI: 1.81-6.85; P < .001; hsTnT > URL - HR 2.17; 95% CI: 1.13-4.16; P = .016; NT-proBNP ≥ 300 pg/mL - HR 2.3; 95% CI: 1.22-4.34; P = .01; G8 score ≤14 points - HR 2.47; 95% CI: 1.29-4.74; P = .007. In multivariate analysis, age-adjusted D-dimer > URL, G8 score ≤ 14 points and visceral metastases remained statistically significant in prediction of inferior TTF. The number of these factors was associated with shorter median TTF: 0-1 factor - 14.1 months; 2 factors - 5.9 months; 3 factors - 2.7 months; P < .001, log-rank). CONCLUSIONS: Age-adjusted D-dimer, and geriatric G8 scores may predict TTF in men with metastatic castration-resistant prostate cancer during AA therapy. These observations require further study in a larger population.

Acute Effects of Ischemic Intra-Conditioning on 30 m Sprint Performance.

The present study aimed to evaluate the effects of ischemic intra-conditioning applied during rest intervals on 30 m sprint performance. Thirty-four trained male (n = 12) and female (n = 22) track and field and rugby athletes volunteered to participate in the study (age = 19.6 ± 4 years; training experience = 5.3 ± 1.9 years). In a randomized and counterbalanced order, participants performed six sets of 30 m sprints under three different testing conditions: without ischemic intra-conditioning, and with ischemic intra-conditioning at 60% or 80% arterial occlusion pressure applied bilaterally before the first trial of the sprint and during the rest periods between all sprint trials. During experimental sessions, subjects perform 6 × 30 m sprints with a 7 min rest interval between attempts. The cuffs were applied following a 1 min rest period and lasted for 5 min before being released at the 6th minute to allow for reperfusion (1 min + 5 min ischemic intra-conditioning + 1 min reperfusion). The two-way repeated measures ANOVA did not show statistically significant condition × set interaction for time of the sprint (p = 0.06; η2 = 0.05). There was also no main effect of ischemic intra-conditioning for any condition (p = 0.190; η2 = 0.05). This study indicates that ischemic intra-conditioning did not enhance the performance of 30 m sprints performed by athletes. However, ischemic intra-conditioning did not decrease performance either.

Acute effects of combined isometric and plyometric conditioning activities on sports performance and tendon stiffness in female volleyball players.

This study aimed to compare the effects of bilateral and unilateral conditioning activities (CA; combined isometric and plyometric) on countermovement jump performance, modified t-agility test, Achilles tendon stiffness and skin surface temperature. Thirteen female semi-professional volleyball players performed two CAs in random order: 1) bilateral isometric half back squats followed by bilateral drop jumps (BI-CA); and 2) unilateral isometric half back squats followed by unilateral drop jumps (UNI-CA). To assess the effects of CAs, countermovement jump, modified t-agility test, Achilles tendon stiffness and skin surface temperature measurements were performed 5 min before and 6 min after the CA. Both CAs significantly increased thigh skin surface temperature from pre- to post-CA (BI-CA, p < 0.001; effect size [ES] = 1.41 and UNI-CA, p = 0.001; ES = 1.39) but none of them influenced modified t-agility test time (interaction: p = 0.338, main effect of time: p = 0.121 and condition: p = 0.819). The countermovement jump height and modified reactive strength index significantly increased from pre-to post-CA during the BI-CA condition (p = 0.003, ES = 0.45, and p = 0.008, ES = 0.48) but not for UNI-CA (p = 0.061, ES = 0.18 and p = 0.065, ES = 0.26). No significant impact has been found for countermovement depth (interaction: p = 0.054, main effect of time: 0.097, and condition: p = 0.41) as well as for contraction time (interaction: p = 0.536, main effect of time: p = 0.224, and condition: p = 0.807). Moreover, stronger and weaker limb CMJ relative peak force significantly decreased from pre-to post-CA (p = 0.014, ES = -0.31, and p = 0.027, ES = -0.26; respectively) during UNI-CA condition but not for BI-CA (p = 0.096, ES = 0.23, and p = 1.41, ES = 0.18). The stronger and weaker limb Achilles tendon stiffness significantly increased from pre-to post-CA during the UNI-CA condition (p = 0.013, ES = 0.60 and p < 0.001, ES = 0.79; respectively) but not for BI-CA (p = 0.66; ES = 0.15 and p = 0.265; ES = 0.42). Furthermore, the post-CA stronger limb Achilles tendon stiffness during the UNI-CA was significantly higher than that noted during the BI-CA (p = 0.006, ES = 0.7). The present study showed that combined isometric and plyometric bilateral CA effectively improved the countermovement jump but did not enhance the t-agility test performance. These findings indicate that exercise combinations could effectively produce a post-activation performance enhancement effect but should replicate the following explosive task as much as possible.

Impact of movement tempo on bar velocity and time under tension in resistance exercises with different external loads.

The goal of the study was to determine the differences between volitional and maximal movement tempo during resistance exercise. Ten healthy men volunteered for the study (age = 26.4 ± 4.8 years; body mass = 93.8 ± 9.6 kg; barbell squat one-repetition maximum (1RM) = 175 ± 16.7 kg; bench press 1RM = 140.5 ± 26.8 kg). In a randomized order, the participants performed six sets of the barbell squat and the bench press exercise at progressive loads from 40% to 90%1RM (step by 10%) under two testing conditions: with volitional movement tempo or with maximal movement tempo. The three-way repeated measures ANOVA showed a statistically significant multi-interaction effect for time under tension (p < 0.001), peak bar velocity (p = 0.04) and for mean bar velocity (p < 0.001). There was also a statistically significant main effect of movement tempo for time under tension (p < 0.001), peak bar velocity (p < 0.001) and for mean bar velocity (p < 0.001). The post hoc analysis for main effect of tempo revealed that time under tension was significantly longer for volitional compared to maximal tempo (0.84 vs 0.67 s, respectively), peak bar velocity was significantly higher for maximal compared to volitional tempo (1.24 m/s vs 0.90 m/s, respectively), and mean bar velocity was significant higher for maximal compared to volitional tempo (0.84 m/s vs 0.67 m/s, respectively). The presented results indicate that there were significant differences between volitional and maximal movement tempos in time under tension and bar velocity (peak and mean), as well as significant differences in those variables between the two exercises. Therefore, the velocity of movement and time under tension is related to movement tempo, external load and type of exercise used.