Long-term results of arthroscopic and mini-open repair of small- to medium-size full-thickness rotator cuff tears.

BACKGROUND: This retrospective cohort study evaluated functional outcome and structural integrity after arthroscopic- or mini-open repair of small- to medium-size rotator cuff tears assessed at long-term follow-up. METHODS: All patients operated between 2001 and 2004 were invited to participate. Functional outcome was measured by Constant-Murley Score, Disability of Arm, Shoulder and Hand and Oxford Shoulder Score. Quality of life was assessed with EuroQol Health 5 Dimension. Patient satisfaction was assessed in terms of pain and overall result. Structural integrity of the rotator cuff repair was determined using ultrasound. RESULTS: Of the eligible 62 patients, 44 patients were available for follow-up. After a mean of 11.3 years, 76% of the patients had good to excellent functional outcome on the Constant-Murley Score (median 82, range 29-95). The majority of patients reported good results on both Disability of Arm, Shoulder and Hand and Oxford Shoulder Score (median Disability of Arm, Shoulder and Hand 5.0, range 1.0-54; median Oxford Shoulder Score 19, range 13-39). The quality of life was also good (mean EuroQol Health 5 Dimension utility score 0.88, standard deviation 0.12). Eighty per cent was satisfied with the overall result. Ultrasound examination revealed structural integrity in 76% of all cases. CONCLUSION: This study shows that functional outcome is good and structural integrity is high for the majority of patients 11.3 years after repair of small- to medium-size rotator cuff lesions.

Evaluation of the use of the hook plate in Neer type 2 lateral clavicle fractures and Rockwood types 3-5 acromioclavicular joint dislocations.

PURPOSE: For most types of acromioclavicular (AC) injuries, treatment is well established. For Neer type 2 lateral clavicle fractures and Rockwood types 3-5 AC dislocations, the ideal treatment is still a point of debate. The purpose of this study was to evaluate the functional and radiological outcome in patients treated for one of these two lesions in our hospital. METHODS: Our study group consisted of 30 patients with a Neer type 2 lateral clavicle fracture (n = 19) or Rockwood types 3-5 AC dislocation (n = 11) treated with the clavicle hook plate. All implants were removed after healing. At a mean follow-up of 40 months (12-92), data were collected by the analysis of questionnaires (DASH, NSST, OSS, SF-36), clinical examination (Constant-Murley score), and radiological evaluation (Zanca view). RESULTS: The mean Constant score was 88 [standard deviation (SD) 8] compared to 92 (SD 6) on the contralateral non-operated side. The questionnaires resulted in the following scores: median DASH: 4.5 (0-70); median NSST: 100 (8-100); mean OSS: 41 (SD 8); mean SF-36: 81 (SD 12). The mean coracoclavicular (CC) and AC distances were not significantly different. CONCLUSIONS: This study suggests that hook plate fixation is a reliable treatment for Neer type 2 lateral clavicle fractures and Rockwood types 3-5 AC injuries. It results in a good and comparable function of the shoulder when compared to the contralateral side, high union rate, good to excellent objective and subjective results, and allows early active motion with limited abduction. A disadvantage is the necessity to remove the plate.

Arthroscopic stabilization of posterior shoulder instability.

Posterior shoulder instability is a rare and challenging condition with a complex patho-anatomy. The role of arthroscopic repair in the treatment remains poorly defined. The purpose of this study is to evaluate the result of arthroscopic stabilization procedures in patients with posterior shoulder instability. In this case series, we treated eighteen patients (19 shoulders) with posterior shoulder instability with either arthroscopic thermal capsular shrinkage (9 patients), capsulorrhaphy (3) or labral refixation (7). There were eight male and ten female patients with a mean age of 26 years. The study group included unidirectional (6 patients; PI), bi-directional (8; PII) and multidirectional posterior instability (5; MDI). The Rowe-score and DASH-score as well as subjective and objective evaluations of the patients function, range of motion, pain and instability were used as clinical outcome measurements. At a mean follow-up of 50 months, the Rowe-score improved significantly from 46 to 74 (P = 0.005). Four patients (21%) had recurrent instability after arthroscopic treatment (2 with generalized ligamentous laxity; 3 after thermal shrinkage). Analysis of postoperative DASH-scores showed a tendency toward inferior outcomes after thermal shrinkage and in patients with an a-traumatic origin of shoulder instability. We conclude that arthroscopic shoulder stabilization by either labral refixation or capsulorrhaphy is a safe and effective treatment for posterior shoulder instability. Thermal capsular shrinkage however showed poor results and should be abandoned for this indication.

Contribution of the reverse endoprosthesis to glenohumeral kinematics.

After placement of a reverse shoulder endoprosthesis, range of motion is usually still compromised. To what extent this occurs from limitation in motion of the reverse endoprosthesis is, however, unclear. We measured the motion pattern of 16 patients (18 shoulders) during three active and passive range of motion tasks using a six degree-of-freedom electromagnetic tracking device. Despite rotator cuff deficiencies, glenohumeral elevation contributed roughly two-thirds of the total thoracohumeral elevation, which is comparable to healthy subjects. However, patients could not actively use the full range of motion provided by the prosthesis. Although we found considerable interindividual differences in shoulder kinematics, the limitation in glenohumeral range of motion appears related to a lack of generated muscle force and not the design of the prosthesis.

Autologous interleukin-1 receptor antagonist improves function and symptoms in osteoarthritis when compared to placebo in a prospective randomized controlled trial.

INTRODUCTION: Incubation of blood with CrSO(4)-coated glass beads stimulates the synthesis of anti-inflammatory cytokines, such as interleukin-1 receptor antagonist (IL-1ra), IL-4, IL-10, and IL-13. As IL-1beta is thought to play a key role in the development of osteoarthritis (OA), this product, also known as Orthokin, might be a viable treatment for symptomatic knee OA. The aim of the current study was to evaluate the efficacy of Orthokin for treatment of symptomatic knee OA in a randomized, multicentre, double-blind, placebo-controlled trial. PATIENTS AND METHODS: One hundred and sixty-seven patients received six intra-articular injections either with Orthokin or physiological saline. The primary efficacy objective consisted of 30% superiority on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) at 3, 6, 9, and 12 months post-treatment. Additionally, the patients completed the visual analogue scale for pain, the Knee injury and Osteoarthritis Outcome Score (KOOS) and Knee Society Clinical Rating System. RESULTS: Orthokin and placebo treatment resulted in similar improvements on the WOMAC (16.8% vs 16.5%, respectively; n.s.). Orthokin resulted in significantly more improvement for KOOS symptom (P = 0.002) and KOOS sport (P = 0.042) parameters as compared to placebo treatment. For most other outcome parameters, Orthokin-treated patients consistently showed higher improvement compared to placebo-treated patients, although none of these differences were statistically significant. Two serious adverse events were observed in the Orthokin group: one patient with repeated severe inflammatory reactions of the knee joint within hours after the injection and one patient with septic arthritis which was attributed to the injection procedure rather than the product. CONCLUSION: The statistically significant improvement of KOOS symptom and sport parameters together with the consistently higher, though non-statistically significant, improvement of most other parameters demonstrates that Orthokin clearly induces a biological response different from placebo treatment and warrant future investigations into the possible chondroprotective effect of Orthokin. However, in the current study the primary efficacy objective was not met and, therefore, the use of Orthokin currently cannot yet be recommended for the treatment of OA.

[The relationship between surgical delay for a hip fracture and the complication risk]. / De samenhang tussen uitstel van operatie bij een heupfractuur en het complicatierisico.

OBJECTIVE: To investigate the factors that contribute to surgical delay and whether this delay can be associated with post-operative complications. DESIGN: Retrospective cohort study. METHOD: Patients admitted with a hip fracture between 1 January 2001-31 December, 2003 to the Onze Lieve Vrouwe Gasthuis, Amsterdam, the Netherlands, were included. The delay before surgery was recorded in 446 patients who underwent surgical treatment for a hip fracture. As possible predictors of delay before surgery, the following factors were investigated: demographic and other patient information, pre-operative medication, co-morbidities, pre-operative acute co-morbidities, classification according to the American Society of Anesthesiologists (ASA) and whether or not the patient had already had surgery to the same hip. To measure the effect of delay before surgery, we investigated post-operative complications like: delirium, decubitus ulcers, urinary tract infections, pulmonary infections, pulmonary embolism, deep vein thrombosis, wound infection, failure ofosteosynthesis and in-hospital mortality. RESULTS: In total, 446 patients, 98 male and 348 female, with a mean age of 82.2 years met the inclusion criteria. Distinct predictors of delay before surgery were: ASA-classification, pre-operative urinary tract infection, pre-operative chest infection, pre-operative delirium, pre-operative anaemia and re-operation. There was no significant association between delay of surgery and the occurrence of post-operative complications. CONCLUSION: Presence of a pre-operative medical condition has an important effect on surgical delay for a hip fracture. The assumption of the Dutch Healthcare Inspectorate that delay of surgery for hip fracture causes more complications could not be confirmed.

Effect of transforming growth factor-beta and growth differentiation factor-5 on proliferation and matrix production by human bone marrow stromal cells cultured on braided poly lactic-co-glycolic acid scaffolds for ligament tissue engineering.

Tissue engineering of ligaments based on biomechanically suitable biomaterials combined with autologous cells may provide a solution for the drawbacks associated with conventional graft material. The aim of the present study was to investigate the contribution of recombinant human transforming growth factor beta 1 (rhTGF-beta1) and growth differentiation factor (GDF)-5, known for their role in connective tissue regeneration, to proliferation and matrix production by human bone marrow stromal cells (BMSCs) cultured onto woven, bioabsorbable, 3-dimensional (3D) poly(lactic-co-glycolic acid) scaffolds. Cells were cultured for 12 days in the presence or absence of these growth factors at different concentrations. Human BMSCs attached to the suture material, proliferated, and synthesized extracellular matrix rich in collagen type I and collagen III. No differentiation was demonstrated toward cartilage or bone tissue. The addition of rhTGF-beta1 (1-10 ng/mL) and GDF-5 (10-100 ng/mL) increased cell content (p < 0.05), but only TGF-beta1 also increased total collagen production (p < 0.05) and collagen production per cell, which is a parameter indicating differentiation. In conclusion, stimulation with rhTGF-beta1, and to a lesser extent with GDF-5, can modulate human BMSCs toward collagenous soft tissue when applied to a 3D hybrid construct. The use of growth factors could play an important role in the improvement of ligament tissue engineering.

Mid-term results of arthroscopic reconstruction in chronic posterior cruciate ligament instability.

The purpose of this study was to evaluate the clinical results of arthroscopic single bundle posterior cruciate ligament (PCL) reconstruction in patients with chronic PCL instability not responding to conservative treatment. 18 patients were available for follow-up with an average elapsed time of 3 years between onset of injury and surgery and an average duration of 3.3 years between reconstruction and evaluation. The clinical results were investigated using the IKDC form, the Tegner rating system, a subjective evaluation, and the VAS for pain rating. The presence of femoral degenerative changes correlated strongly to the elapsed time between injury and operation (P<0.05). Before surgery all patients were graded D (severely abnormal) using the IKDC evaluation form. The final IKDC score at follow-up resulted in grade A (normal) in five patients (28%), grade B (nearly normal) in eight patients (44%), grade C (abnormal) in four patients (22%) and grade D (severely abnormal) in one patient (6%). The VAS score for pain rating revealed very few complaints of pain and it demonstrated a strong correlation between the subjective evaluation and the Tegner rating score (P<0.01). Evaluation of the Tegner score resulted in a significant improvement after surgery when compared to the situation prior to operation (P<0.01). Although there still is some controversy on the indication for treatment of PCL injury, we conclude on the basis of our findings that arthroscopic reconstruction of symptomatic chronic PCL instability, not responding to conservative therapy, can be greatly beneficial.

Tissue engineering of ligaments: a comparison of bone marrow stromal cells, anterior cruciate ligament, and skin fibroblasts as cell source.

Anterior cruciate ligament (ACL) reconstruction surgery still has important problems to overcome, such as "donor site morbidity" and the limited choice of grafts in revision surgery. Tissue engineering of ligaments may provide a solution for these problems. Little is known about the optimal cell source for tissue engineering of ligaments. The aim of this study is to determine the optimal cell source for tissue engineering of the anterior cruciate ligament. Bone marrow stromal cells (BMSCs), ACL, and skin fibroblasts were seeded onto a resorbable suture material [poly(L-lactide/glycolide) multifilaments] at five different seeding densities, and cultured for up to 12 days. All cell types tested attached to the suture material, proliferated, and synthesized extracellular matrix rich in collagen type I. On day 12 the scaffolds seeded with BMSCs showed the highest DNA content (p < 0.01) and the highest collagen production (p < 0.05 for the two highest seeding densities). Scaffolds seeded with ACL fibroblasts showed the lowest DNA content and collagen production. Accordingly, BMSCs appear to be the most suitable cells for further study and development of tissue-engineered ligament.

Satisfactory cross cultural equivalence of the Dutch WOMAC in patients with hip osteoarthritis waiting for arthroplasty.

BACKGROUND: Cross cultural validity is of vital importance for international comparisons. OBJECTIVE: To investigate the validity of international Dutch-English comparisons when using the Dutch translation of the Western Ontario and McMaster Universities osteoarthritis index (WOMAC). PATIENTS AND METHODS: The dimensionality, reliability, construct validity, and cross cultural equivalence of the Dutch WOMAC in Dutch and Canadian patients waiting for primary total hip arthroplasty was investigated. Unidimensionality and cross cultural equivalence was quantified by principal component and Rasch analysis. Intratest reliability was quantified with Cronbach's alpha, and test-retest reliability with the intraclass correlation coefficient. Construct validity was quantified by correlating sum scores of the Dutch WOMAC, Arthritis Impact Measurement Scales (Dutch AIMS2), Health Assessment Questionnaire (Dutch HAQ), and Harris Hip Score (Dutch HHS). RESULTS: The WOMAC was completed by 180 Dutch and 244 English speaking Canadian patients. Unidimensionality of the Dutch WOMAC was confirmed by principal component and Rasch analysis (good fit for 20/22 items). The intratest reliability of the Dutch WOMAC for pain and physical functioning was 0.88 and 0.96, whereas the test-retest reliability was 0.77 and 0.92, respectively. Dutch WOMAC pain sum score correlated 0.69 with Dutch HAQ pain, and 0.39 with Dutch HHS pain. Dutch WOMAC physical functioning sum score correlated 0.46 with Dutch AIMS2 mobility, 0.62 with Dutch AIMS2 walking and bending, 0.67 with Dutch HAQ disability, and 0.49 with Dutch HHS function. Differential item functioning (DIF) was shown for 6/22 Dutch items. CONCLUSIONS: The Dutch WOMAC permits valid international Dutch-English comparisons after correction for DIF.

[Diagnostic image (130). A man with a lateral swelling of the knee. Meniscal cyst]. / Diagnose in beeld (130). Een man met een laterale zwelling aan de knie. Meniscuscyste.

A 35-year-old man had a swelling at the outer side of his left knee due to a meniscal cyst. He was cured by arthroscopic puncture.

Comparison of tibial tunnel enlargement after anterior cruciate ligament reconstruction using patellar tendon autograft or allograft.

This retrospective study was designed to compare tibial tunnel enlargement in patients with autograft or allograft anterior cruciate ligament reconstructions. The changes were related to position of the tibial tunnel and clinical outcome. Twenty-six patients with autograft reconstructions and 41 with allograft reconstructions were studied at a mean follow-up of 59 months (range, 41 to 84) after surgery. The average tunnel enlargement on the anteroposterior view was 2.2 mm (SD, 2.5) for autografts and 2.8 mm (SD, 2.1) for allografts. On the lateral view, the tunnel enlargement was 2.6 mm (SD, 2.4) and 3.4 mm (SD, 2.6) for autografts and allografts, respectively. No significant differences were found between the autograft and allograft groups. A trend was found in the correlation between the position of the tibial tunnel and the tunnel enlargement: more anteriorly placed tunnels had more enlargement. The changes in tunnel diameter did not relate to knee functional score or laxity. There was a significant correlation between malposition of the tibial tunnel and poor clinical scores. A significant negative correlation was found between postoperative follow-up time and tunnel enlargement in both groups. We conclude that placement of the tibial tunnel is a determining factor in tibial tunnel enlargement and clinical knee scores after anterior cruciate ligament replacement with an autograft or allograft. Tunnel enlargement tends to be less at a longer postoperative follow-up.

A new bioabsorbable interference screw: preliminary results of a prospective, multicenter, randomized clinical trial.

SUMMARY: A randomized clinical trial was conducted to compare a bioabsorbable polyglyconate screw (Endo-Fix; Smith & Nephew, Andover, MA) to a metal screw in anterior cruciate ligament reconstruction. A total of 124 patients were operated on and 113 assessed up to 1 year postoperatively. Assessments included a history and physical examination, the IKDC evaluation, and knee arthrometry measurements. No significant differences were found between the groups with respect to any of the IKDC problem areas at 1 year. The IKDC final evaluation was normal or nearly normal in 92% of polyglyconate patients and 90% of controls. The incidence of postoperative complications was similar in the 2 groups. One polyglyconate patient developed a subcutaneous cyst that may have been related to breakdown of the screw. This resolved without treatment and the patient had an excellent clinical outcome. This study shows that the polyglyconate screw is an effective alternative to metal in endoscopic reconstruction of the ACL.

Sonography and magnetic resonance imaging equivalent for the assessment of full-thickness rotator cuff tears.

OBJECTIVE: To investigate the diagnostic value of sonography (SG) and magnetic resonance imaging (MRI) in the assessment of full-thickness rotator cuff tears (RCTs). METHODS: Twenty-one consecutive, otherwise healthy patients with noninflammatory unilateral chronic (>3 months) shoulder complaints due to a possible full-thickness RCT were studied (9 women and 12 men, mean +/- SD age 56 +/- 12). According to standardized procedures, SG was performed by both a radiologist and a rheumatologist, and MRI was evaluated by 2 radiologists. All assessors were blinded to the patient's diagnosis. Within 3 weeks after SG and MRI, arthroscopy was performed. SG, MRI, and arthroscopy results were scored as negative or positive for the presence of a full-thickness RCT. The result of surgical inspection was used as the "gold standard." RESULTS: For full-thickness RCTs, the sensitivity was 0.81 for SG and 0.81 for MRI. The specificity was 0.94 for SG and 0.88 for MRI. The positive predictive value was 0.96 for SG and 0.91 for MRI. The negative predictive value was 0.77 for SG and 0.74 for MRI. Accuracy was 0.86 for SG and 0.83 for MRI. CONCLUSION: Full-thickness RCTs can be identified accurately by both SG and MRI. Because of its low cost and because it can be performed in the rheumatology unit, SG seems to be a promising diagnostic tool for use by the rheumatologist.

Arthroscopic anterior cruciate ligament reconstruction with bone-patellar tendon-bone allograft or autograft. A prospective study with an average follow up of 4 years.

A prospective study was performed with 36 patients who underwent an anterior cruciate ligament (ACL) reconstruction with the use of a fresh-frozen bone-patellar tendon-bone (BPTB) allograft. A group of 26 patients who underwent the same operation conducted by the same surgeon in the same period but with the use of an autograft BPTB served as controls. The average follow-up was 46 (range 30-64) months in the allograft group and 52 (range 42-74) months in the autograft group. The allograft group consisted of 17 men and 19 women with a mean age of 28 years (mean trauma to reconstruction interval was 55 months). The autograft group consisted of 9 men and 17 women with a mean age of 28 years (mean trauma to reconstruction interval was 30 months). Clinical and functional evaluation was performed according to the IKDC guidelines. Analysis of tibial tunnel placement with respect to the Blumenstaat line on a lateral radiograph with the knee in hyperextension was done in relation to an extension deficit and clinical score. In the autograft group 18 (70%) patients had a normal or nearly normal knee and 8, a fair result. In the allograft group 30 (85%) patients had a normal or nearly normal knee, 5 (13%) patients had a fair result, and one (2%) knee was poor. The difference between the two groups was not significant. The allograft BPTB is a good alternative graft in ACL reconstruction.

[One hundred years of orthopedics in Netherlands. V. Arthroscopy]. / Honderd jaar orthopedie in Nederland. V. Artroscopie.

Since the early eighties arthroscopy has become an important part of orthopaedics. Virtually every joint can be examined with an arthroscope. Apart from the diagnostic possibilities, an increasing number of arthroscopically guided surgical operations are possible. Knee arthroscopy can be used therapeutically for many conditions, including meniscal lesions, refractory synovitis, cruciate ligament lesions, tibial plateau fractures and osteochondral defects; in the shoulder it can be applied to lesions of the glenoid lip or the rotator cuff; in the ankle and foot, for osteochondral fractures and creation of an arthrodesis; in the wrist, for treatment of instability, intra-articular distal fractures of the radius and the carpal tunnel syndrome; in the hip, for removal of loose bodies and in the spine, for the performance of discectomy. Advantages over conventional open operations are smaller proportions of complications (< 2%), shorter hospital stay and more rapid rehabilitation. The areas of indication are defined in guidelines issued by the orthopaedic societies themselves; most orthopaedic surgeons follow these guidelines. A possibility for the future is use of laser in interventions on joints.

The uncemented Gerard bipolar double-cup arthroplasty of the hip. A five- to 11-year follow-up study.

Between 1978 and 1984, 183 hips in 154 patients with the uncemented Gerard double-cup arthroplasty were resurfaced. The clinical and radiographic results of the 106 original arthroplasties were reviewed after a median follow-up period of 98 months. Although many of these patients had clinically improved immediately, the Harris Hip score decreased significantly in most hips in subsequent years. No correlation was found between the clinical score and radiographic complications. Major revision surgery with removal of the double cup was performed in 54 of 183 patients, making the cumulative success rate after 132 months only 48%. Survival was significantly greater in patients younger than 50 years of age and in patients with a low body weight (Quetelet index less than 25). This high failure rate eliminates the Gerard double-cup arthroplasty, except possibly for the patient with a destructive inflammatory arthropathy for whom there are no other surgical alternatives.

[Arthroscopic treatment of anterior (sub)luxation of the shoulder]. / Artroscopische behandeling van de anterieure (sub)luxatie van de schouder.

Seventeen patients with a recurrent traumatic anterior shoulder (sub)luxation were operated on by means of arthroscopic capsulorrhaphy. Follow-up averaged 15 months. One patient showed a recurrent subluxation. Complications were rare and only minor. At follow-up the shoulder function was practically normal. All patients were satisfied with the results of the treatment. Nearly all patients resumed their athletic activities at the previous level. Although this method is still in its experimental phase the results of this 'closed' arthroscopic procedure are very satisfactory; and this technique appears promising.