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Am J Surg ; 206(4): 567-73, 2013 Oct.
Article in English | MEDLINE | ID: mdl-23809673

ABSTRACT

BACKGROUND: Neoadjuvant chemotherapy (NACT) is used in breast cancer to evaluate the response to treatment. We examined the usefulness of breast magnetic resonance imaging (MRI) in the evaluation of tumor response after NACT. METHODS: Breast MRIs of 87 women with MRI after NACT were reviewed. The Spearman coefficient was used for estimating the correlation between MRI and pathologic tumor sizes (ypTs). RESULTS: The median age was 50 years (range 25 to 83 years). The median MRI size was 1.25 cm (range 0 to 10 cm). The median ypT was 1.20 cm (range 0 to 10.4 cm). The Spearman coefficient between MRI and ypT was .78 (95% confidence interval, .67 to .85; P < .0001). MRI was found to have a positive predictive value of 92% and a negative predictive value of 64% for residual in-breast disease. The sensitivity and specificity of MRI were 86% and 77%, respectively. CONCLUSIONS: MRI correlates well with the final pathology and can be a useful modality to predict residual disease after NACT and aid in surgical planning.


Subject(s)
Breast Neoplasms/pathology , Breast Neoplasms/therapy , Magnetic Resonance Imaging , Neoadjuvant Therapy , Adult , Aged , Aged, 80 and over , Breast Neoplasms/metabolism , Carcinoma in Situ/metabolism , Carcinoma in Situ/pathology , Carcinoma in Situ/therapy , Carcinoma, Ductal, Breast/metabolism , Carcinoma, Ductal, Breast/pathology , Carcinoma, Ductal, Breast/therapy , Carcinoma, Lobular/metabolism , Carcinoma, Lobular/pathology , Carcinoma, Lobular/therapy , Chemotherapy, Adjuvant , Female , Humans , Mastectomy , Middle Aged , Predictive Value of Tests , Receptor, ErbB-2/metabolism , Retrospective Studies , Sensitivity and Specificity , Triple Negative Breast Neoplasms/pathology , Triple Negative Breast Neoplasms/therapy
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