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1.
Proc Natl Acad Sci U S A ; 109(27): 10811-4, 2012 Jul 03.
Article in English | MEDLINE | ID: mdl-22699494

ABSTRACT

Measurement techniques based upon the Hall effect are invaluable tools in condensed-matter physics. When an electric current flows perpendicular to a magnetic field, a Hall voltage develops in the direction transverse to both the current and the field. In semiconductors, this behavior is routinely used to measure the density and charge of the current carriers (electrons in conduction bands or holes in valence bands)--internal properties of the system that are not accessible from measurements of the conventional resistance. For strongly interacting electron systems, whose behavior can be very different from the free electron gas, the Hall effect's sensitivity to internal properties makes it a powerful tool; indeed, the quantum Hall effects are named after the tool by which they are most distinctly measured instead of the physics from which the phenomena originate. Here we report the first observation of a Hall effect in an ultracold gas of neutral atoms, revealed by measuring a Bose-Einstein condensate's transport properties perpendicular to a synthetic magnetic field. Our observations in this vortex-free superfluid are in good agreement with hydrodynamic predictions, demonstrating that the system's global irrotationality influences this superfluid Hall signal.


Subject(s)
Cold Temperature , Magnetics/methods , Quantum Theory , Semiconductors , Electric Conductivity , Electrons , Evaluation Studies as Topic , Hydrodynamics
2.
Am J Dent ; 24(5): 322-8, 2011 Oct.
Article in English | MEDLINE | ID: mdl-22165462

ABSTRACT

PURPOSE: To demonstrate the robustness of the Featherstone pH cycling model when tested in three independent laboratories and to evaluate the use of "non-inferiority" testing at those laboratories. METHODS: The fundamental principles for the Featherstone laboratory pH cycling model to be an appropriate alternative to animal testing is that it must demonstrate equivalent accuracy to the "Gold Standard" (rat caries model) by: (1) providing a meaningful representation of the caries process; (2) demonstrating a proportionate response to fluoride dose (or concentration); (3) being able to show that clinically proven formulations perform similarly relative to the controls; and (4) differentiating products that have attenuated fluoride activity. RESULTS: This cross-validation study confirmed the ability of the three independent laboratories to discriminate between various concentrations of fluoride-containing dentifrice formulations, demonstrated that clinically proven formulas perform as expected and identified an attenuated fluoride formulation (NaF/CaCO3 dentifrice - 1100 ppm NaF) as inferior compared to the 1100 ppm F (NaF/silica) positive control.


Subject(s)
Animal Testing Alternatives , Cariostatic Agents/therapeutic use , Dental Caries , Dentifrices/chemistry , Fluorides/therapeutic use , Animals , Cattle , Dental Caries/physiopathology , Dental Caries/prevention & control , Dental Enamel , Dentifrices/therapeutic use , Dose-Response Relationship, Drug , Humans , Hydrogen-Ion Concentration , Prospective Studies , Reproducibility of Results
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