Acute opioid administration induces hypothalamic-pituitary-adrenal activation and is mediated by genetic variation in interleukin (Il)1B.

There is a complex relationship between drug dependence and stress, with alcohol and other drugs of abuse both relieving stress and potentially inducing physiological stress responses in the user. Opioid drugs have been shown to modulate hypothalamic-pituitary-adrenal (HPA) activity in animal models and individual response to this modulation may play a role in continuation of drug use. Healthy young Caucasian adults were administered a single dose of immediate release oxycodone (20mg, n=30) or assigned to a control group (n=19) that was not administered the drug. At 0, 1, 2, 4 and 6h post-administration, blood and saliva samples were collected along with assessment of pupil diameter. The HPA response was determined by measurement of salivary cortisol through a commercially available enzyme-linked immunosorbent assay (ELISA). The results were compared to genotype at the -511 and -31 positions in the interleukin1B (IL1B) gene. No difference in cortisol production was initially observed between the two groups, however, when participants were separated based on their genotype for two single nucleotide polymorphisms in the promoter of the IL1B gene, which have been shown to occur at a higher frequency in opioid-dependent populations, individuals carrying the -511T and -31 C alleles (-511 C/T, -31 C/T or -511 T/T, -31 C/C) had a significantly (p<0.05) higher cortisol levels compared to individuals homozygous for the -511 C and -31T alleles. These results suggest that individuals carrying the -511T and -31 C alleles experience HPA activation in response to opioid administration and therefore may be less likely to undertake subsequent self-administration.

Eavesdropping on the family: a pilot investigation of corporal punishment in the home.

This study tested the feasibility of using audio recorders to collect novel information about family interactions. Research into corporal punishment (CP) has relied, almost exclusively, on self-report data; audio recordings have the promise of revealing new insights into the use and immediate consequences of CP. So we could hear how parents respond to child conflicts, 33 mothers wore digital audio recorders for up to 6 evenings. We identified a total of 41 CP incidents, in 15 families and involving 22 parent-child dyads. These incidents were evaluated on 6 guidelines culled from the writings of CP advocates. The results indicated, contrary to advice, CP was not being used in line with 3 of the 6 recommendations and for 2 others, the results were equivocal. The last recommendation could not be assessed with audio. Latency analyses revealed children, after being hit, were misbehaving again within 10 minutes after 73% of the incidents. Mothers' self reports about whether they used CP were found to correspond to the audio data in 81% of the cases. Among the mothers who were hitting, CP occurred at a much higher rate than the literature indicates. These results should be viewed as preliminary because of the small sample of families and the even smaller number of families who used CP. Nevertheless, this pilot study demonstrates that audio recording naturally occurring momentary processes in the family is a viable method for collecting new data to address important questions about family interactions.