ABSTRACT
The correlation between the absorbed energy and the induced biological damage still has unclear aspects, especially in the low energy and low dose rate irradiation regimes. From the knowledge of the molecular-induced effects (dissociations), it would be possible to better understand the side effects of radiation, such as induced cancers or damage to healthy tissue. With this in view, this paper presents results of a simulation of a 125I-seed treatment with an event-by-event MC code (LEPTS) specifically designed to account for the low energy secondary particle interactions, such as electron attachment, vibro-rotational and neutral dissociation interactions. This calculation allowed us to analyze the potential radiation damage not only in connection with the energy deposition, but also in terms of induced molecular dissociations by taking into account ionizing and non-ionizing dissociative processes. We propose that this description of the molecular level damage be the basis for nanodosimetric evaluations.
Subject(s)
Iodine Radioisotopes/adverse effects , Brachytherapy/adverse effects , Computer Simulation , Humans , Iodine Radioisotopes/administration & dosage , Iodine Radioisotopes/analysis , Male , Monte Carlo Method , Prostatic Neoplasms/radiotherapy , Radiation Dosage , Radiopharmaceuticals/administration & dosage , Radiopharmaceuticals/adverse effects , Radiopharmaceuticals/analysis , Radiotherapy Planning, Computer-Assisted/statistics & numerical data , WaterABSTRACT
The present study introduces LEPTS, an event-by-event Monte Carlo programme, for simulating an ophthalmic (106)Ru/(106)Rh applicator relevant in brachytherapy of ocular tumours. The distinctive characteristics of this code are the underlying radiation-matter interaction models that distinguish elastic and several kinds of inelastic collisions, as well as the use of mostly experimental input data. Special emphasis is placed on the treatment of low-energy electrons for generally being responsible for the deposition of a large portion of the total energy imparted to matter.
Subject(s)
Electrons/therapeutic use , Eye/radiation effects , Radioisotopes/therapeutic use , Rhodium/therapeutic use , Ruthenium Radioisotopes/therapeutic use , Computer Simulation , Humans , Monte Carlo MethodABSTRACT
The Spanish National Reference Database for Ionizing Radiations (BANDRRI) is being implemented by a reasearch team in the frame of a joint project between CIEMAT (Unidad de Metrologia de Radiaciones Ionizantes and Direccion de Informatica) and the Universidad Nacional de Educacion a Distancia (UNED, Departamento de Mecanica y Departamento de Fisica de Materiales). This paper presents the main objectives of BANDRRI, its dynamic and relational data base structure, interactive Web accessibility and its main radionuclide-related contents at this moment.
