ABSTRACT
Isolated primary non-Hodgkin's lymphoma of the frontal sinus is rare. We describe the case of a middle-aged man who came to us with signs of orbital cellulitis complicating an acute infected frontal mucocele. His condition was initially controlled with medical therapy and subsequent endoscopic sinus surgery, but his symptoms eventually returned. We were able to diagnose the lymphoma only by approaching the sinus externally to obtain a biopsy. This case highlights the importance of making a full visual inspection of the involved sinus in order to avoid missing an unexpected, albeit a rarely encountered, pathology.
Subject(s)
Frontal Sinus , Lymphoma, B-Cell/diagnosis , Mucocele/complications , Paranasal Sinus Neoplasms/diagnosis , Postoperative Complications/diagnosis , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Cellulitis/etiology , Contraindications , Endoscopy , Frontal Sinus/pathology , Frontal Sinus/surgery , Humans , Lymphoma, B-Cell/complications , Lymphoma, B-Cell/pathology , Lymphoma, B-Cell/therapy , Male , Middle Aged , Mucocele/surgery , Paranasal Sinus Neoplasms/complications , Paranasal Sinus Neoplasms/pathology , Paranasal Sinus Neoplasms/therapy , Reoperation , Tomography, X-Ray ComputedABSTRACT
We have examined the incidence of Harvey ras mutations in human squamous cell carcinomas (SCC) of the upper aerodigestive tract using the polymerase chain reaction (PCR) followed by direct sequencing. No mutations were detected at codons 12, 13, 59 or 61 of this gene in any of six papillomas, five erythroplakias, 56 squamous cell carcinomas, and 16 SCC cell lines. Some of the SCC were lymph node metastases (three) or tumours which had recurred following radiotherapy (seven). We conclude that Harvey ras mutations are not a common event in the pathogenesis or recurrence of SCCs from Caucasian subjects, in contrast to the situation with Indian populations (Saranath et al., 1991).
Subject(s)
Carcinoma, Squamous Cell/genetics , Genes, ras , Head and Neck Neoplasms/genetics , Base Sequence , Humans , Molecular Sequence Data , Mutation , Polymerase Chain Reaction , Tumor Cells, Cultured , White PeopleSubject(s)
Ferricyanides , Halothane , Hypotension, Controlled , Metoprolol , Nitroprusside , Propanolamines , Adolescent , Adult , Anesthesia, Intravenous , Blood Pressure/drug effects , Drug Administration Schedule , Ear/surgery , Electrocardiography , Ferricyanides/administration & dosage , Heart Rate/drug effects , Humans , Male , Metoprolol/administration & dosage , Middle Aged , Nitroprusside/administration & dosage , Nose/surgery , Parotid Gland/surgery , Propanolamines/administration & dosageABSTRACT
A prospective survey of 738 children with high risk factors was carried out in the north-east of Scotland. High risk factors used in previous surveys were reviewed and considered inadequate. New and stringent standards are described. Results are compared with the national incidence of sensori-neural deafness and with other surveys.
