1.
BMJ Qual Saf
; 31(3): 230-233, 2022 03.
Article
in English
| MEDLINE
| ID: mdl-35046102
2.
Genomics
; 83(4): 566-71, 2004 Apr.
Article
in English
| MEDLINE
| ID: mdl-15028279
ABSTRACT
Alternative splicing of pre-mRNAs is an important mechanism for the generation of vertebrate protein diversity. Unfortunately, the contribution of alternative splicing to protein diversity is currently not well understood because many full-length mRNA sequences have yet to be identified. In this report, we describe the use of RT-PCR to identify and clone 279 novel alternatively spliced mRNAs from 114 well-known drug target genes. Our findings demonstrate the existence of many novel alternatively spliced mRNA transcripts and suggest that many more genes undergo functionally significant alternative splicing than previously thought.