Subject(s)
Nerve Regeneration , Neurology/history , Spinal Cord/physiology , Animals , History, 20th Century , Rats , Research/history , United StatesABSTRACT
This is an account of the vicissitudes of the monkeys on Cayo Santiago. In it is described the relationship of the establishment of that primate colony to the development of the National Regional Primate Research Center Program in the United States and the Laboratory of Perinatal Physiology in Puerto Rico. The Cayo Santiago colony opened new aspects of biomedical research and stimulated the general use of nonhuman primates in behavioral as well as physiological investigations.
Subject(s)
Axons/physiology , Nerve Regeneration , Spinal Cord/physiology , Animals , Brain/physiology , Lampreys , Larva/physiologySubject(s)
Nerve Regeneration , Spinal Cord Injuries/physiopathology , Adult , Age Factors , Animals , Axons/physiology , Cats , Dogs , Female , Humans , Hypothermia, Induced , Male , Membranes, Artificial , Nerve Growth Factors/therapeutic use , Nerve Regeneration/drug effects , Pancreatic Elastase/therapeutic use , Peripheral Nerves/surgery , Peripheral Nerves/transplantation , Pyrogens/therapeutic use , Rats , Sex Factors , Spinal Cord/ultrastructure , Spinal Cord Injuries/therapy , Time Factors , Transplantation, Autologous , Trypsin/therapeutic use , Wounds, Nonpenetrating , Wounds, PenetratingSubject(s)
Spinal Cord Injuries/physiopathology , Spinal Cord Injuries/therapy , Age Factors , Animals , Cats , Disease Models, Animal , Dogs , Female , Humans , Hyaluronoglucosaminidase/therapeutic use , Nerve Regeneration , Pancreatic Elastase/therapeutic use , Paraplegia/physiopathology , Pyrogens/therapeutic use , Quadriplegia/physiopathology , Rats , Spinal Cord Injuries/surgery , Spinal Cord Neoplasms/surgery , Trypsin/therapeutic useSubject(s)
Central Nervous System/physiology , Nerve Regeneration , Animals , Axonal Transport , Biological Transport , Catecholamines/metabolism , Central Nervous System/metabolism , Humans , Nerve Growth Factors/physiology , Neural Pathways , Neurons/physiology , Neurons/transplantation , Paraplegia/physiopathology , Spinal Cord/physiology , Synapses/physiology , Transplantation, HomologousSubject(s)
Animals, Newborn/growth & development , Asphyxia Neonatorum/complications , Attention Deficit Disorder with Hyperactivity/etiology , Disease Models, Animal , Animals , Asphyxia Neonatorum/pathology , Brain/pathology , Depth Perception , Distance Perception , Haplorhini , Humans , Infant, Newborn , Learning Disabilities/etiology , Macaca , Memory , Memory, Short-Term , Motor Activity , Nerve Regeneration , Psychomotor Disorders/etiology , Reaction Time , Thalamus/pathology , Time FactorsABSTRACT
In "Developmental behaviors: delayed appearance in monkeys asphyxiated at birth" by J. A. Sechzer et al. (19 Mar., p. 1173), the last two lines of column 1 and the first five lines of column 2, page 1175, should read "Deficits in learning and memory (10, 11) when compared with the establishment of these developmental behaviors (although significantly delayed) suggest that brain damage by neonatal asphyxia can result in a degree of dissociation..."
ABSTRACT
Developmental behaviors were studied in monkeys subjected to asphyxia at birth. Visual depth perception, visual pla ing, and locomotion appeared significantly later than in nonasphyxiated monkeys. After these behaviors had been established in asphyxiates, however, there was little difference from those observed in normal monkeys. These results were compared with reports of permanent learning deficits that occur in monkeys asphyxiated at birth for similar periods of time. Such comparison suggests that the neural structures responsible for the developmental behaviors studied are not damaged by asphyxia to the same extent as those for acquisition. Delay in development may be an early indication of brain damage with subsequent mental retardation.
Subject(s)
Animals, Newborn , Asphyxia Neonatorum/physiopathology , Behavior, Animal , Depth Perception , Amnesia/etiology , Animals , Brain Diseases/complications , Developmental Disabilities/diagnosis , Humans , Hypoxia, Brain/complications , Infant, NewbornABSTRACT
The brains of monke guinea pigs asphyxiated at birth pletely resuscitated, and killed a ous times thereafter revealed no chial hemorrhages. However, postnatal distress and other factoring to a moribund state occurro brains revealed petechial hemor.
