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1.
Clin Case Rep ; 9(12): e05229, 2021 Dec.
Article in English | MEDLINE | ID: mdl-34963810

ABSTRACT

This report describes surgical decompression and stabilization of 2 hemivertebrae in a German shepherd dog. Long-term clinical and imaging outcomes are documented. Spinal cord decompression via corpectomy improved neurological function and intrinsic spinal cord changes on MRI. The dog improved to have minimal paraparesis and an active lifestyle.

2.
Clin Tech Small Anim Pract ; 21(2): 76-81, 2006 May.
Article in English | MEDLINE | ID: mdl-16711613

ABSTRACT

Chronic inflammatory rhinitis is commonly found in dogs with chronic nasal disease and is characterized by lymphoplasmacytic infiltrates in the nasal mucosa in the absence of an obvious etiologic process. The pathogenesis of lymphoplasmacytic rhinitis remains unknown. Animals respond poorly to antibiotics, oral glucocorticoids, and antihistamines, making primary infectious, immune-mediated, or allergic etiologies unlikely. Aberrant immune response to inhaled organisms or allergens may induce inflammation in some animals. Common clinical signs include nasal discharge, sneezing, coughing, epistaxis, and stertor. Diagnosis is made by performing a thorough history, physical examination, radiography or advanced imaging (via computed tomography or magnetic resonance imaging), rhinoscopy, and nasal mucosal biopsy to rule out primary etiologies of nasal discharge. Treatment strategies have included various antibiotics, antihistamines, oral and inhalant steroids, nonsteroidal antiinflammatories, and antifungal medications. Some dogs may respond partially to doxycycline or azithromycin, although it is unclear whether response is related to antimicrobial or antiinflammatory properties of these drugs. Hydration of the nasal cavity through nasal drops or aerosols may limit nasal discharge, and some animals may improve with inhalant (but rarely oral) glucocorticoids.


Subject(s)
Dog Diseases/pathology , Endoscopy/veterinary , Nasal Mucosa , Rhinitis/veterinary , Animals , Anti-Bacterial Agents/therapeutic use , Anti-Inflammatory Agents/therapeutic use , Antifungal Agents/therapeutic use , Dog Diseases/diagnosis , Dog Diseases/diagnostic imaging , Dog Diseases/drug therapy , Dogs , Endoscopy/methods , Nasal Mucosa/cytology , Nasal Mucosa/pathology , Radiography , Rhinitis/diagnosis , Rhinitis/diagnostic imaging , Rhinitis/pathology
3.
J Vet Intern Med ; 20(2): 250-6, 2006.
Article in English | MEDLINE | ID: mdl-16594580

ABSTRACT

Lymphoplasmacytic rhinitis (LPR) is a common histologic finding in dogs with chronic nasal disease; however, potential etiologies of this disorder have not been examined. We investigated the hypothesis that specific microbes contribute to clinical disease in dogs with LPR. Paraffin-embedded nasal biopsies were obtained from 19 dogs with LPR, 10 dogs with nasal neoplasia, and 10 dogs with nasal aspergillosis. Nucleic acids were extracted from paraffin blocks, and real-time quantitative polymerase chain reaction (PCR) was employed for detection of target genes for bacterial and fungal DNA, canine adenovirus 2 (CAV-2), parainfluenza virus 3 (PI-3), Chlamydial Chlamydophila spp., and Bartonella spp. Conventional PCR was used for detection of Mycoplasma spp. Statistical analysis was performed using the Mann-Whitney U-test for nonparametric data, and significance was set at P < 0.05. DNA or RNA for CAV-2, PI-3, Bartonella, Mycoplasma, and Chlamydophila was not detected in any nasal biopsy. DNA loads for bacterial DNA did not differ among disease groups. Detection of fungal DNA in nasal biopsies was highest in dogs with aspergillosis (P < 0.0001); however, nasal biopsies of LPR dogs also displayed higher fungal DNA levels than samples from dogs with nasal neoplasia (P = 0.016). Detection of high levels of fungal DNA in nasal biopsies of dogs with LPR suggests that fungal organisms may be causally associated with the inflammation observed, although the possibility of entrapment or accumulation of fungi in the nasal cavity due to chronic inflammation cannot be excluded. Further investigations are required to elucidate the underlying etiopathogenesis of LPR.


Subject(s)
Bacterial Infections/veterinary , Dog Diseases/microbiology , Mycoses/veterinary , Nasal Mucosa/microbiology , Polymerase Chain Reaction/veterinary , Rhinitis/veterinary , Virus Diseases/veterinary , Animals , Bacterial Infections/diagnosis , DNA, Bacterial/analysis , DNA, Fungal/analysis , DNA, Viral/analysis , Dog Diseases/diagnosis , Dogs , Mycoses/diagnosis , Polymerase Chain Reaction/methods , RNA, Viral/analysis , Rhinitis/microbiology , Virus Diseases/diagnosis
4.
J Am Vet Med Assoc ; 224(12): 1952-7, 2004 Jun 15.
Article in English | MEDLINE | ID: mdl-15230450

ABSTRACT

OBJECTIVE: To determine clinical signs and rhinoscopic, computed tomographic, and histologic abnormalities in dogs with idiopathic lymphoplasmacytic rhinitis. DESIGN: Retrospective case series. ANIMALS: 37 dogs. PROCEDURE: Clinical information was obtained from medical records. Nasal computed tomographic images and histologic slides of biopsy specimens were reviewed. RESULTS: Dogs ranged from 1.5 to 14 years old (mean, 8 years); most (28) were large-breed dogs. Nasal discharge was unilateral in 11 of 26 (42%) dogs and bilateral in 15 of 26 (58%) dogs. In dogs with unilateral disease, duration of clinical signs ranged from 1.5 to 36 months (mean, 8.25 months; median, 2 months), and in dogs with bilateral disease, duration of signs ranged from 1.25 to 30 months (mean, 6.5 months; median, 4 months). Computed tomography (n = 33) most often revealed fluid accumulation (27/33 [82%]), turbinate destruction (23/33 [70%]), and frontal sinus opacification (14/33 [42%]). Rhinoscopy (n = 37) commonly demonstrated increased mucus and epithelial inflammation; turbinate destruction was detected in 8 of 37 (22%) dogs. Bilateral biopsy specimens from all 37 dogs were examined. Four dogs had only unilateral inflammatory changes. The remaining 33 dogs had bilateral lesions; in 20, lesions were more severe on 1 side than the other. CONCLUSIONS AND CLINICAL RELEVANCE: Findings suggest that idiopathic lymphoplasmacytic rhinitis is a key contributor to chronic nasal disease in dogs and may be more common than previously believed. In addition, findings suggest that idiopathic lymphoplasmacytic rhinitis is most often a bilateral disease, even among dogs with unilateral nasal discharge.


Subject(s)
Dog Diseases/pathology , Nasal Mucosa/pathology , Rhinitis/veterinary , Animals , Biopsy/veterinary , Dog Diseases/diagnosis , Dogs , Endoscopy/veterinary , Female , Male , Nasal Mucosa/cytology , Retrospective Studies , Rhinitis/diagnosis , Rhinitis/pathology , Tomography, X-Ray Computed/veterinary
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