Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Mol Biol Rep ; 41(11): 7053-62, 2014 Nov.
Article in English | MEDLINE | ID: mdl-25103020

ABSTRACT

Mitochondria are highly specialized in function, but mitochondrial and, therefore, cellular integrity is maintained through their dynamic nature. Through the frequent processes of fusion and fission, mitochondria continuously change in shape and adjust function to meet cellular requirements. Abnormalities in fusion/fission dynamics generate cellular dysfunction that may lead to diseases. Mutations in the genes encoding mitochondrial fusion/fission proteins, such as MFN2 and OPA1, have been associated with an increasing number of genetic disorders, including Charcot-Marie-Tooth disease type 2A (CMT2A) and autosomal dominant optic atrophy. In this review, we address the mitochondrial dynamic changes in several important genetic diseases, which will bring the new insight of clinical relevance of mitochondrial genetics.


Subject(s)
GTP Phosphohydrolases/metabolism , Genetic Diseases, Inborn/physiopathology , Mitochondrial Diseases/physiopathology , Mitochondrial Dynamics/physiology , Mitochondrial Proteins/metabolism , Apoptosis/physiology , Humans , Oxidative Stress/physiology
SELECTION OF CITATIONS
SEARCH DETAIL
...