Evaluation of the application of veterinary judgement in the pre-emptive cull of contiguous premises during the epidemic of foot-and-mouth disease in Cumbria in 2001.

This paper presents a detailed analysis of the application of contiguous culling in Cumbria between May 1 and September 30, during the outbreak of foot-and-mouth disease in 2001. The analysis shows that the application of veterinary risk assessment and judgement identified and removed groups of susceptible stock which were at risk of direct transmission of infection and avoided infected animals being left that might have spread the disease. When compared with an automatic contiguous cull, fewer culls were made and some of these were reduced in scale, providing economies in the use of resources. The data suggest that farms contiguous to an infected premises faced a 5 per cent risk of infection by direct transmission and a 12 per cent risk of infection by indirect transmission.

Treatment of tinea imbricata: a randomized clinical trial using griseofulvin, terbinafine, itraconazole and fluconazole.

BACKGROUND: Griseofulvin has been the mainstay of treatment for tinea imbricata (TI) for decades; however, there have been few reports of efficacy of newer antifungals in the treatment of this condition. Many patients with TI have several obstacles to treatment due to their remote geographical locations and the primitive nature of their societies. OBJECTIVES: The aim of this study was to compare the efficacy of itraconazole, terbinafine and fluconazole with that of griseofulvin after 4 weeks of therapy. METHODS: Patients aged 12-76 years with the clinical diagnosis of TI were randomly assigned to one of four treatment groups: griseofulvin 500 mg twice daily for 4 weeks, terbinafine 250 mg daily for 4 weeks, itraconazole 200 mg twice daily for 1 week or fluconazole 200 mg once weekly for 4 weeks. Disease activity was monitored weekly. Laboratory measurements included monitoring complete blood count and liver function enzymes. Fifty-nine patients were included in the efficacy analysis: 13 in the fluconazole group, 15 in the griseofulvin group, 12 in the terbinafine group and 19 in the itraconazole group. RESULTS: Significant remission was achieved in the terbinafine and griseofulvin groups, lasting up to 8 weeks after cessation of therapy. The fluconazole group experienced no significant remission, and remission was of short duration in the itraconazole group. No adverse events were reported, and non-compliance with medications or follow-up was the only reason for removal from the study. CONCLUSIONS: Griseofulvin and terbinafine are effective in the treatment of TI. The decision of whether to treat at all and which medication to choose depends greatly on the extent of involvement, the social situation, and the availability of resources such as laboratory testing and follow-up.

Adult aging and listening patterns for spoken prose: spontaneous segmentation versus self-paced listening.

Young and older adults were allowed to control the delivery rate of spoken prose for later recall using two methods. In one method (spontaneous segmentation), participants were allowed to interrupt speech passages whenever they wished. In the other method (self-paced listening), speech passages were presented in segments, with participants allowed to initiate presentation of subsequent segments via a key-press. Older adults' segment sizes in the spontaneous segmentation condition were unchanged when the passages were presented for a second time. By contrast, pause latencies to initiating subsequent segments in the self-paced listening condition were affected by experience with the passage. Results suggested that the segment sizes selected in the spontaneous segmentation condition were driven by the linguistic structure and prosody of the speech, rather than reflecting ineffective metamemory on the part of the older adults.

Memory and encoding of spoken discourse following right hemisphere damage: evidence from the Auditory Moving Window (AMW) technique.

We investigated the hypotheses that impaired discourse processing following right hemisphere damage is mediated by task difficulty and is associated with deficits in discourse encoding. Spoken discourse passages differing in contextual predictability were presented to right hemisphere-damaged (RHD) patients and to non-brain-damaged (NBD) controls for subsequent recall using the Auditory Moving Window paradigm. To manipulate processing difficulty, speech segments were of normal or accelerated speech rates. The recall results showed that RHD adults recalled less than NBD controls overall and failed to recall major idea units better than minor idea units for high predictability passages presented at accelerated speech rates. Both RHD patients and NBD controls failed to recall major idea units better than minor idea units for low predictability passages, regardless of speech rate. The encoding results showed that RHD adults were both slower overall and differentially slower than NBD controls when listening to accelerated passage segments. Taken together, the encoding and recall results are consistent with the view that extracting passage gist under difficult listening conditions is especially vulnerable for patients with right hemisphere strokes.

Resource allocation during spoken discourse processing: effects of age and passage difficulty as revealed by self-paced listening.

The allocation of processing resources during spoken discourse comprehension was studied in a manner analogous to self-paced reading using the auditory moving window technique (Ferreira, Henderson, Anes, Weeks, & McFarlane, 1996). Young and older participants listened to spoken passages in a self-paced segment-by-segment fashion. In Experiment 1, we examined the influence of speech rate and passage complexity on discourse encoding and recall performance. In Experiment 2, we examined the influence of speech rate and presentation mode (self-paced vs. full-passage presentation) on recall performance. Results suggest that diminished memory performance in the older adult group relative to the young adult group is attributable to age-related differences in how resources were allocated during the initial encoding of the spoken discourse.

A functional relation between learning and organization in free recall.

It is well known that multitrial free recall is accompanied by increased organization of output over learning trials, even when the order of presentation is randomized. We compared the relation between learning and organization in 30 young and 30 older adults as they learned categorized materials to a criterion of 100% recall. The importance of this age manipulation was that it allowed us to examine, using two groups that differ significantly in their learning ability, whether organization and learning follow the same function. As was expected, older adults showed less organization on any given learning trial. However, when equated for degree of learning, the older adults showed approximately the same level of organization as the young. This finding suggests that the organization-learning relation remains invariant in the face of significant differences in participants' mnemonic abilities.

Effects of age and hearing sensitivity on the use of prosodic information in spoken word recognition.

It is well known that spoken words can often be recognized from just their onsets and that older adults require a greater word onset duration for recognition than young adults. In this study, young and older adults heard either just word onsets, word onsets followed by white noise indicating the full duration of the target word, or word onsets followed by a low-pass-filtered signal that indicated the number of syllables and syllabic stress (word prosody) in the absence of segmental information. Older adults required longer stimulus durations for word recognition under all conditions, with age differences in hearing sensitivity contributing significantly to this age difference. Within this difference, however, word recognition was facilitated by knowledge of word prosody to the same degree for young and older adults. These findings suggest, first, that listeners can detect and utilize word stress in making perceptual judgments and, second, that this ability remains spared in normal aging.

One voice too many: adult age differences in language processing with different types of distracting sounds.

An experiment is reported that investigated factors that might contribute to age differences in the ability to process spoken language under conditions of competition from various types of background noise. Age differences in recall of spoken sentences were shown to depend on the type of background noise as well as its intensity. Increased intensity levels of just one competing speaker produced differentially greater impairment in older adults than in young adults. Analyses showed that listening performance was predicted not only by individual differences in hearing ability but also by speed of processing, which underscores the combined role of age-related auditory and cognitive changes in processing spoken language.

Regaining lost time: adult aging and the effect of time restoration on recall of time-compressed speech.

Two experiments in which time was restored to artificially accelerated (time-compressed) speech are reported. Experiment 1 showed that although both young and older adults' recall of the speech benefited from the restoration of time, time restoration failed to boost the older adults to their baseline levels for unaltered speech. In Experiment 2, either 100% or 125% of lost time was restored by inserting pauses, either at linguistic boundaries or at random points within the passages. Experiment 2 showed that the beneficial effects of time restoration depended on where processing time was inserted, as well as how much time was restored. Results are interpreted in terms of age-related slowing in speech processing moderated by preserved linguistic knowledge and short-term conceptual memory.

The influence of prosodic structure on the interpretation of temporary syntactic ambiguity by young and elderly listeners.

The contribution of prosody to the interpretation of temporary syntactic ambiguity was examined for young and elderly listeners using a sentence-completion task. Temporary syntactic ambiguity refers to cases where it may be temporarily unclear whether a syntactic clause boundary has or has not been reached based on what has been heard in the sentence to that point. Results suggest that both young and elderly adults use a computationally less demanding late-closure parsing strategy whenever possible, but that sentence prosody can override this tendency when an alternative closure position is clearly signaled. Although subtle differences appeared in regard to sentence completion strategies and latencies to completion, results suggest that efficient resolution of syntactic boundary uncertainty and effective use of sentence prosody are two features of language comprehension that remain well-preserved in normal aging.

An experimental and computational analysis of age differences in the recognition of fragmented pictures: inhibitory connections versus speed of processing.

Young and older adults were tested for the ability to identify degraded pictures presented either in a series of incremental steps with each step increasing the completeness of the visual information (ascending condition) or in one single exposure (fixed condition). Significant interference effects, indicated by a superiority of fixed over ascending presentations, appeared at a lower level of performance for the older adults than for the young adults. This finding was consistent with the notion of an inhibition deficit operating in normal aging. A computer simulation, based on simple connectionist architecture, demonstrated that an age-related inhibition deficit in the identification of fragmented pictures can be produced by slowed processing rates.

The role of prosody in the mental lexicon.

Current models of spoken word recognition take into account factors such as word frequency, word onset cohort size, and phonological neighborhood density. Using the word onset gating technique we tested word recognition when bandpass filtering was used to allow subjects to hear the full prosodic pattern of a word (number of syllables and syllabic stress), deprived of segmental information beyond that contained in the onset gate. Subjects also heard either word onsets plus duration information or only word onsets. Results suggest that word prosody is represented in the mental lexicon and is effectively used by listeners in spoken word recognition.

Effects of age and passage difficulty on listening-rate preferences for time-altered speech.

When younger and older adults were allowed to adjust the speech rate of time-compressed and time-expanded speech passages, older adults tended to select as preferred rates significantly slower speech rates than the younger adults. Both age groups, however, selected slower rates for difficult speech passages (low cloze predictability) than for easy passages (high cloze predictability). Recall performance showed effects of speech rate and passage difficulty, with participants' recall at their selected speech rates comparable to their performance at slower rates. Results suggest that older adults are as effective as the young in their ability to monitor the difficulty of a speech passage as it is being heard and to moderate their listening rate selections accordingly.

Decision latencies for phonological and semantic information in object identification.

Several on-line studies in the literature have been cited in support of a two-stage model of name-retrieval in which semantic processing precedes and mediates access to phonology. Because of inconsistencies in prior studies an off-line experiment was designed to provide converging evidence on this issue. An experiment is reported in which young and elderly adults were required to give speeded judgments of whether a pictured object matched a named category, a named physical attribute, or a rhyming cue. Latencies for the young adults were fastest for category judgments and slowest for rhyming judgments. For the elderly adults physical attributes and rhyming judgments were equivalent. Results are discussed in terms of "lemma" theory in object naming.

The boston corpus of aphasic naming errors.

This report provides verbatim error responses to picture naming given by 30 aphasic patients (10 Broca's aphasics, 6 Wernicke's aphasics, 7 conduction aphasics, and 7 anomic aphasics). The error corpus is intended to supply a rich set of raw data for investigators interested in the characteristics of aphasic word-finding problems as well as those interested in general models of lexical retrieval.

Response latencies for false memories: gist-based processes in normal aging.

Three experiments have demonstrated that age-related increases in both probability and speed of false recognitions for word lists depended on the use of a gist-based memory strategy. When test conditions promoted a gist strategy, both younger and older participants were as likely to falsely recognize a thematically associated lure as to correctly recognize a studied item, and both groups were equally fast in making these decisions. However, when test conditions deemphasized a gist-based strategy, older adults were more likely than younger adults, and faster, to falsely recognize both strong and weakly associated lures. These findings suggest an age-related increase in reliance on gist-based processing that may underlie age differences in false memory.

The changing relationship between anatomic and cognitive explanation in the neuropsychology of language.

Changing trends in the approach to neurolinguistics are reviewed. We suggest that these trends are marked by a distinct convergence between linguistic/cognitive and anatomic/physiological approaches to the study of aphasia. With respect to the former, we cite the refinement of analysis of language symptoms and the introduction of experimental methods that reveal real-time aspects of language processing. With respect to the latter, we cite the technical advances in static and dynamic brain imaging that have allowed the in vivo analysis of lesion sites in aphasic patients, and the identification of foci of metabolic activity during linguistic/cognitive tasks in normal brains. We cite recent imaging studies of category-specific lexical dissociations as examples of the productive convergence of anatomic and technological advances to illuminate a particularly challenging problem.

Taking charge of remembering: locus of control and older adults' memory for speech.

The relation between control beliefs and recall of spoken word lists and prose passages was assessed for 32 older adults, ages 62 to 85, in a task where they were given control over presentation of stimuli. They differed in the degree to which they believed that factors within their control (internals) or outside their control (externals) affected their intellectual functioning; they were similar in age, education, vocabulary, and digit span. They were required to stop the speech input at points of their own choosing to recall the stimuli on a segment-by-segment basis. Externals were more likely than internals to make inaccurate predictions of the number of words they could remember and to choose longer segments than they could recall. Results suggest that externals are poorer than internals in monitoring on-line memory processing.

The importance of word-initial phonology: error patterns in prolonged naming efforts by aphasic patients.

Whether multiple conscious efforts at word search bring a subject closer to an elusive word and to eventual successful retrieval remains a subject of debate. Previous work with normal participants has shown that multiple attempts eventuating in correct retrieval are not usually associated with a systematic progression toward target word phonology in the intervening attempts. In this study we analyzed the naming errors produced by 30 aphasic patients who had received the Boston Naming Test. The analyses were designed to elucidate the characteristics of responses that led to eventual success. Our data showed that among aphasics, as with normal subjects, the presence of target-initial phonology in the subject's first response was the most important predictor of correct retrieval. Moreover, progression towards target phonology in the course of multiple attempts was unrelated to eventual correct retrieval.

Judgments of concept similarity by normal and aphasic subjects: relation to naming and comprehension.

A study was conducted in which aphasic patients, age-matched normals, and normal young adults performed five types of matching judgments for object pictures. These required matching for physical identity, basic object identity, and membership in the same superordinate category. Spoken name-to-picture matching was tested for the last two conditions. An analogous set of conditions was presented for letters. Latency patterns across the conditions showed general slowing for the aphasic patients, but with a differential decrement in the conditions that involved auditory (spoken name) input for the matching task. Results showed that variations in semantic judgment capability among the aphasics did not predict the patients' object naming ability.