ABSTRACT
Thiols have been shown to be related to insulin secretion and to uptake of glucose into tissues. In the present study the effects of i.v. administration of acetylcysteine (N-acetylcysteine, NAC, CAS 616-91-1) on glucose consumption and plasma free thiols were studied in young healthy volunteers during hyperglycemic clamp. NAC (0.5-2.0 mg/kg) significantly increased glucose consumption. This effect was not obvious at higher doses of NAC. Plasma free NAC depended on the dose of NAC injected. The t1/2 of NAC was 11 min. NAC produced significant increases of plasma cysteine concentrations, and a slight but insignificantly increase of plasma glutathione. These data suggest that a moderate increase in plasma thiols augments glucose consumption during hyperglycemic clamp.
Subject(s)
Acetylcysteine/pharmacology , Blood Glucose/metabolism , Glucose/metabolism , Acetylcysteine/adverse effects , Acetylcysteine/pharmacokinetics , Adult , Female , Glutathione/blood , Half-Life , Humans , Insulin/blood , Male , Models, BiologicalABSTRACT
We present the case of a 21-year-old woman with an acute monocytic leukemia. When she was in complete hematological remission, she developed rapid progressive hemiparesis on the right caused by a left frontoparietal chloroma as confirmed by surgery and histological examination. Postoperatively, the patient recovered completely, and x-ray therapy followed. Since intracerebral myeloblastic tumors are extremely rare and since the neurosurgeon may be involved in treatment of these lesions, we are encouraged to present our findings.
Subject(s)
Brain Neoplasms/surgery , Frontal Lobe/surgery , Leukemia, Monocytic, Acute/surgery , Leukemia, Myeloid/surgery , Neoplasms, Second Primary/surgery , Parietal Lobe/surgery , Adult , Brain Neoplasms/pathology , Cerebral Angiography , Female , Frontal Lobe/pathology , Humans , Leukemia, Monocytic, Acute/pathology , Leukemia, Myeloid/pathology , Neoplasms, Second Primary/pathology , Parietal Lobe/pathology , Tomography, X-Ray ComputedABSTRACT
A 48-year-old woman with diabetes mellitus (type IIb) had to be treated with insulin because of poor blood-sugar control. Infiltrates at the sight of injection occurred with two different porcine insulin preparations, necessitating a switch to human insulin. After the third injection of the latter an anaphylactic reaction developed within minutes. During a pregnancy in 1968 the patient had briefly received bovine insulin. Tests now revealed an immediate-type allergy against all three available species insulins, which was successfully treated by hyposensitisation.
Subject(s)
Anaphylaxis/chemically induced , Desensitization, Immunologic , Insulin/adverse effects , Anaphylaxis/prevention & control , Animals , Cattle , Diabetes Mellitus, Type 2/drug therapy , Female , Humans , Immunoglobulin G/analysis , Immunoglobulin M/analysis , Insulin/immunology , Insulin Antibodies/analysis , Middle Aged , Pregnancy , Pregnancy in Diabetics/drug therapy , Species Specificity , Swine , Time FactorsABSTRACT
Intracranial tuberculomas today are rare in industrialized countries. We report the case of a 29 year old female German patient who in the sixth month of her pregnancy presented with epilepsy and mild hemiparesis. Cranial CT showed a parietal contrast-enhancing lesion. Mediastinal tuberculosis was confirmed by biopsy. Both the mediastinal and the cerebral lesion together with the neurological signs resolved under therapy with antituberculous drugs, and the patient gave birth to a healthy child.
