1.
Bioorg Med Chem Lett
; 17(1): 78-81, 2007 Jan 01.
Article
in English
| MEDLINE
| ID: mdl-17049233
ABSTRACT
We describe an optimized series of acyclic hydroxyethylamine transition state isosteres of beta-secretase that incorporates a variety of P(2) side chains that yield potent inhibitors with excellent cellular activity. A 2.2A crystal structure of compound 13 is shown.