1.
Diabetologia
; 42(9): 1131-7, 1999 Sep.
Article
in English
| MEDLINE
| ID: mdl-10447526
ABSTRACT
AIMS/HYPOTHESIS: To investigate the contribution of mutations in maturity-onset diabetes of the young (MODY) and mitochondrial genes to early-onset diabetes with a strong family history of diabetes in a cohort with a high prevalence of Type I (insulin-dependent) diabetes mellitus. METHODS: Screening for sequence variants in the hepatocyte nuclear factor (HNF)-4alpha (MODY1), glucokinase (MODY2), HNF-1alpha (MODY3) genes and mitochondrial DNA was carried out in 115 Finnish and Swedish patients with early-onset (
Subject(s)
DNA, Mitochondrial/genetics , Diabetes Mellitus, Type 2/genetics , Genetic Variation , Glucokinase/genetics , Mutation , Nuclear Proteins , Phosphoproteins/genetics , Polymorphism, Single-Stranded Conformational , Transcription Factors/genetics , Adult , Age Factors , Aged , Aged, 80 and over , Basic Helix-Loop-Helix Leucine Zipper Transcription Factors , DNA-Binding Proteins/genetics , Diabetes Mellitus, Type 2/enzymology , Exons , Family , Female , Hepatocyte Nuclear Factor 1 , Hepatocyte Nuclear Factor 1-alpha , Hepatocyte Nuclear Factor 1-beta , Hepatocyte Nuclear Factor 4 , Humans , Introns , Male , Middle Aged , Pedigree , Point Mutation , Promoter Regions, Genetic , Scandinavian and Nordic Countries , Sequence Deletion
2.
Diabetes
; 48(2): 423-5, 1999 Feb.
Article
in English
| MEDLINE
| ID: mdl-10334325
