ABSTRACT
INTRODUCTION: Pachymeningitis is a fibrous inflammatory process with non-specific symptoms, involving the dura mater. Due to MRI development, diagnosis is both easier and earlier. CURRENT KNOWLEDGE AND KEY POINTS: We report seven cases and review current literature. Clinical features are headaches and cranial nerve palsies. CSF shows inflammatory changes, while MRI evidences thickening of the dura mater. Disease etiologies in the present study were tuberculosis in two cases, sarcoidosis, Lyme disease, lymphoma and dural puncture; in one case only the disease was of unknown origin. The condition of six patients improved with specific treatment. FUTURE PROSPECTS AND PROJECTS: Further MRI development should allow detection of new forms of pachymeningitis and standardization of patients' management through the study of more important series.
Subject(s)
Brain Diseases/diagnosis , Dura Mater/pathology , Meningitis/diagnosis , Adult , Aged , Brain Diseases/etiology , Brain Diseases/therapy , Female , Humans , Magnetic Resonance Imaging , Male , Meningitis/etiology , Meningitis/therapy , Middle AgedABSTRACT
The authors report a trial on the antidepressive activity of L.5-H.T.P. The clinical population is relatively homogeneous; it consists of melancholic patients, aged over 50. The results are inferior to those obtained with other antidepressant therapies. They do not verify that L.5-H.T.P. has an antidepressive action in elderlies. However, the authors do not put aside that L.5-H.T.P. can be interesting in some varieties of depression.
