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1.
Praxis (Bern 1994) ; 93(9): 315-20, 2004 Feb 25.
Article in French | MEDLINE | ID: mdl-15060972

ABSTRACT

Over the past two decades, multiple observational studies have suggested that hormone replacement therapy (HRT) reduced the risk of fracture, increased the quality of life and protected against the cardiovascular disease. HRT was often recommended, on the basis of this evidence, for that indications. But these recommendations were based entirely on observational evidence, which can sometimes be misleading. In the early 1990, several large randomized studies were initiated. The largest of these trials, the Women Health Initiative (WHI) was stopped prematurely last summer (only the group with estrogen plus progestin) because the disadvantages outweighted the advantages of treatment. The conclusions of that study were largely debated in the press and destabilised more than one patient or doctor. The Swiss menopausal society published some directive to precise the indications of HRT.


Subject(s)
Hormone Replacement Therapy , Osteoporosis, Postmenopausal/prevention & control , Age Factors , Aged , Alzheimer Disease/epidemiology , Breast Neoplasms/epidemiology , Cardiovascular Diseases/epidemiology , Cardiovascular Diseases/prevention & control , Climacteric , Colonic Neoplasms/epidemiology , Endometrial Neoplasms/epidemiology , Estrogens, Conjugated (USP)/administration & dosage , Female , Follow-Up Studies , Hormone Replacement Therapy/adverse effects , Humans , Hysterectomy , Medroxyprogesterone/administration & dosage , Meta-Analysis as Topic , Middle Aged , Multivariate Analysis , Ovarian Neoplasms/epidemiology , Placebos , Prognosis , Prospective Studies , Quality of Life , Randomized Controlled Trials as Topic , Risk , Risk Factors , Socioeconomic Factors , Time Factors
3.
J Gynecol Obstet Biol Reprod (Paris) ; 27(3): 265-76, 1998 Apr.
Article in French | MEDLINE | ID: mdl-9648004

ABSTRACT

There has been a dramatic reduction in the incidence of neonatal mortality due to fetal hemolytic disease since the introduction of Rhesus prophylaxis. Although routinely used since 1968, the exact mode of action of anti-D IgGs is still not fully understood. Notable advances have taken place in the screening and the management of fetal hemolytic disease. This article describes the antibody detection in the mother, and the fetal management with ultrasound amniocentesis, fetal blood sampling and intrauterine transfusions. Finally, the postnatal management is also considered.


Subject(s)
Erythroblastosis, Fetal/diagnosis , Erythroblastosis, Fetal/prevention & control , Prenatal Diagnosis/methods , Rho(D) Immune Globulin/therapeutic use , Algorithms , Decision Trees , Erythroblastosis, Fetal/etiology , Humans , Infant, Newborn , Postnatal Care
4.
J Gynecol Obstet Biol Reprod (Paris) ; 27(2): 135-43, 1998 Mar.
Article in French | MEDLINE | ID: mdl-9599759

ABSTRACT

Perinatal hemolytic disease is characterized by the destruction of fetal red blood cells by maternal antibodies directed against membrane antigens and can lead to immune fetal hydrops. More than 250 blood group antigens have been described. After considering the particular situation of ABO incompatibility, this article describes the classification of red blood cells antigens, with particular reference to the Rhesus system. Other antigens such as Kell, Kidd, Duffy, MNSs, P and Lutheran are also considered.


Subject(s)
Blood Group Antigens/immunology , Erythroblastosis, Fetal/complications , Erythroblastosis, Fetal/immunology , Blood Group Antigens/classification , Blood Group Antigens/genetics , Erythroblastosis, Fetal/blood , Humans , Hydrops Fetalis/immunology , Infant, Newborn , Phenotype , Polymorphism, Genetic
5.
Hum Reprod ; 11(6): 1173-6, 1996 Jun.
Article in English | MEDLINE | ID: mdl-8671417

ABSTRACT

The case of an arterial aorto-subclavian thromboembolism associated with a moderate ovarian hyperstimulation syndrome (OHSS) and following ovulation induction for in-vitro fertilization in a young woman is reported. Because of the lack of response to systemic thrombolysis, a left postero-lateral thoracotomy was performed on day 8 after embryo transfer. A fibrinocruoric embolus situated at the junction of the left subclavian artery from the aorta was removed through a left subclavian arteriotomy. The distal axillary embolus was removed by a retrograde balloon catheter embolectomy. A moderate OHSS was observed. The ovarian stimulation and OHSS-related risks of thromboembolism are discussed. We conclude that, in the absence of risk factors, counselling about possible complications resulting from stimulation must be emphasized.


Subject(s)
Ovarian Hyperstimulation Syndrome/complications , Ovulation Induction/adverse effects , Thromboembolism/etiology , Adult , Aorta , Chorionic Gonadotropin/therapeutic use , Female , Gonadotropin-Releasing Hormone/agonists , Humans , Menotropins/therapeutic use , Ovulation Induction/methods , Subclavian Artery , Triptorelin Pamoate/therapeutic use
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