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1.
Effect of malathion on the initiation and elongation steps of transcription.
Walter, Z; Wiszkowska, H.
Acta Biochim Pol ; 37(1): 73-6, 1990.
Article in English | MEDLINE | ID: mdl-2087919

ABSTRACT

In isolated cell nuclei of pig thymus malathion, S-1,2-bis(ethoxycarbonyl)-ethyl-O,O-dimethyldithiophosphate inhibited both initiation and elongation of all three classes of nuclear RNA polymerases; proflavin was used as an inhibitor of initiation, and actinomycin, as an inhibitor of elongation.


Subject(s)
Cell Nucleus/metabolism , Malathion/pharmacology , Transcription, Genetic/drug effects , Animals , Dactinomycin/pharmacology , Kinetics , Proflavine/pharmacology , Swine , Thymus Gland/metabolism
2.
[Effect of malathion (O,O-dimethyl-S-1,2-dicarboethoxy-ethyl-dithiophosphate) on the transcription activity of chromatin in vitro and transcription products in cell nuclei from the calf thymus gland]. / Wplyw malationu (O,O-dimetylo-s-1,2-dikarboetoksyetylo-ditiofosforanu) na aktywnosc transkrypcyjna chromatyny in vitro i produkty transkrypcji w jadrach komórkowych z grasicy cielecia.
Wiszkowska, H; Walter, Z.
Folia Med Cracov ; 28(1-2): 185-92, 1987.
Article in Polish | MEDLINE | ID: mdl-2442080

Subject(s)
Cell Nucleus/metabolism , Chromatin/drug effects , Malathion/pharmacology , Thymus Gland/metabolism , Transcription, Genetic/drug effects , Animals , Cattle , In Vitro Techniques , RNA/metabolism , Thymus Gland/ultrastructure
3.
The effect of malathion on RNA polymerase activity of cell nuclei and transcription products in lymphocyte culture.
Wiszkowska, H; Kulamowicz, I; Malinowska, A; Walter, Z.
Environ Res ; 41(2): 372-7, 1986 Dec.
Article in English | MEDLINE | ID: mdl-2430789

ABSTRACT

Malathion decreased polymerase activity of cell nuclei and inhibited RNA synthesis in cultured lymphocytes. The mechanism of action of this compound at the cellular level is suggested.


Subject(s)
Cell Nucleus/drug effects , DNA-Directed RNA Polymerases/antagonists & inhibitors , Lymphocytes/drug effects , Malathion/toxicity , Transcription, Genetic/drug effects , Cell Nucleus/enzymology , Cells, Cultured , Humans , Lymphocytes/metabolism , RNA/biosynthesis
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