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1.
The joint toxic action of perchloroethylene with benzene or toluene in rats.
Withey, R J; Hall, J W.
Toxicology ; 4(1): 5-15, 1975.
Article in English | MEDLINE | ID: mdl-1129807

ABSTRACT

The joint toxic action of mixtures of perchloroethylene with benzene or toluene was tested at five dose levels for each of six binary combinations with 20 rats per dose. LD50 data with 95% fiducial limits are reported for each mixture and tests for additive joint toxicity were made. The results indicate that the mixtures of perchloroethylene and benzene gave values for the LD50 which were slightly less than additive while perchloroethylene and toluene mixtures had LD50 values which could not be predicted by an additive model.


Subject(s)
Benzene/toxicity , Tetrachloroethylene/toxicity , Toluene/toxicity , Animals , Drug Interactions , Lethal Dose 50 , Male , Models, Biological , Rats
2.
A sensitive micro method for the analysis of benzene in blood.
Withey, R J; Martin, L.
Bull Environ Contam Toxicol ; 12(6): 659-64, 1974 Dec.
Article in English | MEDLINE | ID: mdl-4457178

Subject(s)
Benzene/blood , Animals , Benzene/analysis , Chromatography, Gas/methods , Humans , Microchemistry/methods , Swine , Time Factors , Water/analysis
3.
The surgical preparation and maintenance of pigs in biovailability studies.
Withey, R J; Willes, R F; Evans, J; Bryce, F R.
Lab Anim Sci ; 23(1): 122-5, 1973 Feb.
Article in English | MEDLINE | ID: mdl-4347752

Subject(s)
Biopharmaceutics , Swine/metabolism , Anesthesia, Inhalation , Animals , Catheterization/instrumentation , Dermatologic Surgical Procedures , Femoral Vein , Halothane , Methods , Saphenous Vein , Silicone Elastomers
4.
Proceedings: Bioavailability and therapeutic efficacy.
Withey, R J.
Rev Can Biol ; 32: Suppl:21-30, 1973.
Article in English | MEDLINE | ID: mdl-4777602

Subject(s)
Biopharmaceutics , Drug Therapy , Pharmaceutical Preparations/metabolism , Animals , Chloramphenicol/blood , Chloramphenicol/metabolism , Dosage Forms , Dose-Response Relationship, Drug , Intestinal Absorption , Pharmaceutical Preparations/administration & dosage , Solubility , Swine
5.
Studies on the physiological availability and metabolism of sulfonamides. 3. Triple sulfa.
Withey, R J; Van Petten, G R; Lettau, H F.
J Clin Pharmacol New Drugs ; 12(5): 190-5, 1972.
Article in English | MEDLINE | ID: mdl-4555877

Subject(s)
Biopharmaceutics , Sulfadiazine/metabolism , Sulfamerazine/metabolism , Sulfamethazine/metabolism , Sulfonamides/metabolism , Administration, Oral , Adult , Analysis of Variance , Clinical Trials as Topic , Drug Combinations , Humans , Male , Middle Aged , Solutions , Sulfadiazine/administration & dosage , Sulfamerazine/administration & dosage , Sulfamethazine/administration & dosage , Tablets , Time Factors
6.
Agitation of the solvent in tablet dissolution studies--a flow visualization technique.
Withey, R J; Bowker, A J.
J Pharm Pharmacol ; 24(5): 345-51, 1972 May.
Article in English | MEDLINE | ID: mdl-4403801

Subject(s)
Tablets/standards , Technology, Pharmaceutical , Oscillometry , Photography , Rotation , Solubility , Viscosity
7.
The kinetics of dissolution for a non-disintegrating standard substrate.
Withey, R J.
J Pharm Pharmacol ; 23(8): 573-82, 1971 Aug.
Article in English | MEDLINE | ID: mdl-4397739

Subject(s)
Sodium Chloride , Equipment and Supplies , Kinetics , Mathematics , Solubility , Technology, Pharmaceutical
8.
The physiologic availability of solid dosage forms of phenylbutazone. I. In vivo physiologic availability and pharmacologic considerations.
Van Petten, G R; Feng, H; Withey, R J; Lettau, H F.
J Clin Pharmacol New Drugs ; 11(3): 177-86, 1971.
Article in English | MEDLINE | ID: mdl-5211351

Subject(s)
Phenylbutazone/blood , Absorption , Administration, Oral , Adult , Analysis of Variance , Biopharmaceutics , Evaluation Studies as Topic , Humans , Male , Phenylbutazone/administration & dosage , Phenylbutazone/metabolism , Tablets , Time Factors
9.
The physiologic availability of solid dosage forms of phenylbutazone. II. Correlation of in vivo physiologic availability and in vitro dissolution parameters.
Withey, R J; Feng, H; Cook, D; Van Petten, G R; Lettau, H F.
J Clin Pharmacol New Drugs ; 11(3): 187-96, 1971.
Article in English | MEDLINE | ID: mdl-5211352

Subject(s)
Phenylbutazone/metabolism , Administration, Oral , Biopharmaceutics , Half-Life , Intestinal Absorption , Models, Biological , Phenylbutazone/administration & dosage , Phenylbutazone/blood , Solubility , Tablets , Time Factors
10.
Studies on the physiological availability and metabolism of sulfonamides. I. Sulfadiazine.
Van Petten, G R; Becking, G C; Withey, R J; Lettau, H F.
J Clin Pharmacol New Drugs ; 11(1): 27-34, 1971.
Article in English | MEDLINE | ID: mdl-4926393

Subject(s)
Biopharmaceutics , Sulfadiazine/metabolism , Adult , Clinical Trials as Topic , Humans , In Vitro Techniques , Intestinal Absorption , Male , Middle Aged , Solubility , Sulfadiazine/blood , Sulfadiazine/urine , Tablets , Time Factors
11.
Studies on the physiological availability and metabolism of sulfonamides. II. Sulfisoxazole.
Van Petten, G R; Becking, G C; Withey, R J; Lettau, H F.
J Clin Pharmacol New Drugs ; 11(1): 35-41, 1971.
Article in English | MEDLINE | ID: mdl-4926394

Subject(s)
Biopharmaceutics , Sulfisoxazole/metabolism , Adult , Clinical Trials as Topic , Humans , In Vitro Techniques , Intestinal Absorption , Male , Middle Aged , Solubility , Sulfisoxazole/blood , Sulfisoxazole/urine , Tablets , Time Factors
12.
A critical analysis of a capsule dissolution test.
Withey, R J; Mainville, C A.
J Pharm Sci ; 58(9): 1120-6, 1969 Sep.
Article in English | MEDLINE | ID: mdl-5346077

Subject(s)
Capsules , Chloramphenicol , Lactose , Methods , Pharmacopoeias as Topic , Solubility/standards , Spectrophotometry , Time Factors , Ultraviolet Rays
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