ABSTRACT
OBJECTIVE: Probiotics and cranberry have been shown to inhibit Helicobacter pylori in vitro owing to bacteriocin production and high levels of proanthocyanidins, respectively. These effects have been confirmed in clinical trials with H. pylori-positive subjects. The aim of this study was to evaluate whether regular intake of cranberry juice and the probiotic Lactobacillus johnsonii La1 (La1) may result in an additive or synergistic inhibition of H. pylori in colonized children. METHODS: A multicentric, randomized, controlled, double-blind trial was carried out in 295 asymptomatic children (6-16 y of age) who tested positive for H. pylori by (13)C-urea breath test (UBT). Subjects were allocated in four groups: cranberry juice/La1 (CB/La1), placebo juice/La1 (La1), cranberry juice/heat-killed La1 (CB), and placebo juice/heat-killed La1 (control). Cranberry juice (200 mL) and La1 product (80 mL) were given daily for 3 wk, after which a second UBT was carried out. A third UBT was done after a 1-mo washout in those children who tested negative in the second UBT. RESULTS: Two hundred seventy-one children completed the treatment period (dropout 8.1%). Helicobacter pylori eradication rates significantly differed in the four groups: 1.5% in the control group compared with 14.9%, 16.9%, and 22.9% in the La1, CB, and CB/La1 groups, respectively (P < 0.01); the latter group showed a slight but not significant increase when compared with the other treated groups. The third UBT was carried out only in 19 of the 38 children who tested negative in the second UBT and H. pylori was detected in 80% of them. CONCLUSION: These results suggest that regular intake of cranberry juice or La1 may be useful in the management of asymptomatic children colonized by H. pylori; however, no synergistic inhibitory effects on H. pylori colonization were observed when both foodstuffs were simultaneously consumed.
Subject(s)
Helicobacter Infections/prevention & control , Helicobacter pylori/growth & development , Lactobacillus/physiology , Proanthocyanidins/pharmacology , Probiotics , Vaccinium macrocarpon/chemistry , Adolescent , Beverages , Breath Tests , Child , Cross-Over Studies , Double-Blind Method , Drug Synergism , Female , Helicobacter Infections/microbiology , Humans , Male , Treatment OutcomeSubject(s)
Humans , Male , Candy , Food, Fortified , Sports , Adult , Anaerobiosis , Body Composition/drug effects , Body Weight/drug effects , Energy Intake , Energy Metabolism , English Abstract , Food Preferences , Oxygen Consumption/drug effectsABSTRACT
O propósito desse estudo foi examinar o efeito imediato e retardado dos lipídios séricos e lipoproteicos em mulheres que competem em triatlon. Oito mulheres triatletas treinadas foram examinadas. Todas fizeram parte de uma competiçao de triatlon que consistiu em 1,9 Km de nataçao, 90 Km de ciclismo e 21 Km de corrida. As amostras sangüíneas foram obtidas 24 horas antes da competiçao (-24h) e a 10 minutos, 24h, 48h e 72h pós exercício. A análise incluiu determinaçoes dos triglicerídeos plasmáticos (TG), colesterol total (TC), lipoproteínas - colesterol de alta densidade (HDL-C), lipoproteínas-colesterol de baixa densidade (LDL-C) e glicerol (G). Mudanças significativas nao foram encontradas em triglicerides. O Glicerol sérico aumentou aos 10 minutos após o triatlon (177.6 mumol.1(-1); p<0.006), enquanto LDL-C decresceu ao mesmo tempo (126mg.dl-1 para 77mg.dl-1; p<0,05). Além disso, um aumento tardio ocorreu em TG ao redor das 72h após o triatlon (51.6 mg.dl-1 para 70.3mg.dl(-1); p < 0,05). Finalmente nós encontramos uma diminuiçao significativa em TG as 24h após o triatlon. Esses resultados demonstram que o triatlon de longa duraçao induz a alteraçoes imediatas e tardias os lipídeos séricos e lipoproteínas em mulheres treinadas.
