The influence of chronic periodontitis on serum TNF-alpha, IL-6 and hs-CRP concentrations, and function of graft and survival of kidney transplant recipients.

OBJECTIVE: The aim of the study is to analyze whether chronic periodontitis (CP) influences serum tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and high-sensitivity C-reactive protein (hs-CRP) concentrations in renal transplant recipients and patients or graft survival. BACKGROUND: CP is associated both with higher serum concentrations of cytokines and CRP and high cardiovascular risk. METHODS: One hundred and seventeen patients with a transplanted kidney (Tx) were divided according to the Community Periodontal Index of Treatment Needs (CPITN) into two subgroups: TxP+: severe CP (CPITN 3-4) and TxP-: no or moderate CP (CPITN 0-2). The control group (C) consisted of 36 subjects with no kidney disease and with no or moderate CP (CPITN 0-2). RESULTS: hs-CRP concentration was higher in TxP+ than in TxP- patients [2.0 mg/L (0.7-4.4) vs. 0.9 mg/L (0.3-1.9), p = 0.006]. There were no differences in serum TNF-alpha and IL-6 between TxP+ and TxP-. Significant positive correlation between CPITN score and hs-CRP concentration was found both in Tx and C. The hazard ratio of death was 7.17 (1.4-76.4) for TxP+ patients. CP status did not increase the risk of graft loss or doubling of serum creatinine. CONCLUSIONS: Severe CP is associated with increased serum hs-CRP concentration in patients after kidney transplantation. Severe periodontitis seems to increase the risk of patients' death after kidney transplantation.

Association between chronic periodontal disease and left ventricular hypertrophy in kidney transplant recipients.

Periodontal disease (PD) may cause a systemic inflammatory reaction and contribute to left ventricular hypertrophy (LVH) in hypertensive subjects. This study aimed to assess whether chronic PD may contribute to LVH in patients after kidney transplantation. The study analyzed 99 patients divided according to Community Periodontal Index of Treatment Needs (CPITN) score into patients with advanced PD (CPITN 3-4) and patients without or with moderate periodontal lesions (CPITN 0-2). Patients with CPITN 3 to 4 were characterized by a significantly higher plasma high-sensitivity C-reactive protein (HS-CRP) concentration (6.2+/-2.2 vs. 1.7+/-0.3 mg/L, P<0.05) and left ventricular mass index (LVMI) (150+/-7 vs. 111+/-3 g/m, P<0.001) in comparison with patients with CPITN 0 to 2. In the multiple regression model, LVMI was dependent on CPITN (P<0.001), HS-CRP (P<0.05), serum cholesterol (P<0.05), and creatinine concentration (P<0.05). In conclusion, it appears that advanced PD in patients after kidney transplantation is associated with LVH.

[Influence of smoking tobacco on the condition of dentition and occurence of periodontal diseases in patients of the Clinic of Maxillo-Facial Surgery at the Silesian Medical Academy in Katowice]. / Wplyw palenia tytoniu na stan uzebienia i wystepowania chorób przyzebia wsród pacjentów Kliniki Chirurgii Szczekowo- Twarzowej SAM w Katowicach.

Popularity of smoking cigarettes in the Polish society is a widely known and discussed subject. Negative effects of smoking cigarettes as well as passive expose to the tobacco smoke are often described. Still, only a few publications focus on the frequency of a smoking habit among patients of clinics and facial and maxillary surgery wards as well as its influence on condition of their oral cavities. It is obvious that these people should particularly avoid smoking cigarettes due to the deterioration of the oral cavity hygiene, substantial differences in healing wounds and induction of neo-plastic changes. The goal of the survey was examining the frequency of the smoking habit among patients of the Departmental Outpatient Clinic of Maxillo-Facial Surgery at the Silesian Medical Academy in Katowice, the assessment of influence of the smoking habit on the oral cavity condition and hygiene. The survey covered 50 patients have been selected at random and they are all treated in the Departmental Outpatient Clinic of Maxillo-Facial Surgery at the Silesian Medical Academy in Katowice. The patients' age was from 21 to 64. In the group being surveyed, 17 patients (34% of the whole) admitted to the smoking habit. 7 patients, the so-called "heavy smokers", admitted to smoking more than 5 cigarettes a day (this group equalled 14% of the whole). Ten patients (20% of the whole) were moderate smokers who smoked fewer than 5 cigarettes a day. In spite of efforts of managing physicians, advertisements supporting a healthy lifestyle, and discouraging information on packets of cigarettes, fighting the habit is very difficult and it does not always lead to giving up smoking.

[The effect of tobacco smoking on occurrence of precancerous lesions and cancers of oral cavity--literature reviews and own experiences]. / Wplyw palenia tytoniu na wyst powanie zmian przednowotworowych i nowotworów jamy ustnej--przeglqd pismiennictwa i doswiadczenia wlasne.

Tobacco smoking results in many serious health problems. It exhibits also significant influence on oral health and is linked with occurrence of oral precancers and cancers. In this paper, on the basis of literature review and own experiences, we tried to prove the close relationship between tobacco smoking and occurrence of oral precancers, their malignant transformations and therapeutic effects. We pointed out on significantly higher cancer occurrence in this region among smokers. We emphasized the role of physicians, whose professional interest was focused on oral health, in prophylaxis of oral cancers and advising patients smoking cessation.

[Cigarette smoking practices in patients with malignant neoplasms of the oral cavity and jaws]. / Palenie papierosów wsród pacjentów z nowotworami jamy ustnej i szczek.

The aim of this study was to estimate the cigarette smoking practices in patients with malignant neoplasms of the oral cavity and jaws, who were treated in the Outpatient Department of the Maxillofacial Department of Silesian Medical Academy in Katowice from january 2000 to june 2004. It was found that significant number of patients (100% of men and 72.72% of women) with oral squamous cell carcinoma had been smoking in the period of time preceding appearance of neoplasm. The men smoked more cigarettes a day and started smoking in a younger age than women. Gender factor did not influence significantly the period of time from starting of smoking practices to the appearance of neoplasm. The patients with the other types of neoplasms denied cigarette smoking.