ABSTRACT
Vulvar malignant melanoma is a rare neoplasm with mostly poor prognosis. As compared with malignant melanoma of the skin vulvar melanoma infiltrates early deep into tissues and into abundant lymph and blood vascularisation. Epidemiology, clinical and histopathological data of primary vulvar melanoma are presented. Currently used methods of treatment are analysed. According to many authors the radical vulvar excision with bilateral lymphangiectomy in all stages of melanoma is a treatment of choice. Due to small population of patients with vulvar melanoma the randomized trials comparing different methods of treatment are not existing. Vulvar melanoma remains controversial medical problem with poor prognosis.
Subject(s)
Melanoma/therapy , Vulvar Neoplasms/therapy , Female , Humans , Melanoma/epidemiology , Melanoma/pathology , Prognosis , Vulvar Neoplasms/epidemiology , Vulvar Neoplasms/pathologyABSTRACT
DNA content in 61 different types of melanocytic nevi was determined by video-imaging cytometry. The nevi were selected for this study because of melanoma risk associated with each nevus, which is 20-50% according to different authors. DNA ploidy was detected in paraffin embedded and fresh tissue material of each patient and the results were comparable. The sample preparation process and video-imaging method were presented in this study, 47 (77.0%) lesions exhibited diploid cell populations, 13 (21.3%) aneuploid and 1 (1.7%) tetraploid cell population. A significant correlation was observed between DNA ploidy measured in fresh tissue and retrospective material. The results indicate the presence of abnormal DNA content in some of the lesions.
