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Daru ; 25(1): 10, 2017 Apr 17.
Article in English | MEDLINE | ID: mdl-28416008

ABSTRACT

Physicians often come across with cases of vitamin K antagonists-dependent coagulopathy for reasons such as accidental use of the vitamin K antagonists (VKA), excessive administration of prescribed anticoagulants of indirect action or not reported administration of vitamin K antagonists due to memory impairment and/or other mental disorders, even deliberate use thereof (attempt to murder or suicide). Rodenticide-poisoning (coumarins, warfarins) via food or occupational accidents are difficult to diagnose. This article discusses different types of acquired vitamin K-dependent coagulopathy. Differential diagnosis is primarily based on patient statements before additional causes of vitamin K deficiency are explored. Even when pathological vitamin K deficiency is not determined, appropriate and urgent medical treatment is necessary: administration of fresh frozen plasma or concentrated factors of the prothrombin complex, administration of vitamin K remedies along with symptomatic therapy. With early diagnosis and prescription of appropriate therapy, prognosis is favorable. Reasons for vitamin K antagonists-dependent coagulopathy cases.


Subject(s)
Anticoagulants/adverse effects , Blood Coagulation Disorders/chemically induced , Vitamin K/antagonists & inhibitors , Anticoagulants/poisoning , Blood Coagulation Disorders/diagnosis , Blood Coagulation Disorders/therapy , Drug Overdose/complications , Humans , Vitamin K/physiology
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