Antibiotic prophylaxis in spine surgery: a comparison of single-dose and 72-hour protocols.

BACKGROUND: Despite the general consensus on the use of single-dose antimicrobial prophylaxis (AMP) in instrumented spine surgery, evidence supporting this approach is not robust. AIM: To compare the efficacies of single-dose and 72 h AMP protocols for the prevention of surgical site infection (SSI) in instrumented spine surgery (ISS) in a before-and-after study. METHODS: Prospective non-randomized cohort study on 5208 patients who underwent spine surgery in one neurosurgical department between 2003 and 2014. Two protocols of AMP were compared in ISS: a single-dose protocol from 2003 to 2008, and a 72 h protocol from 2009 to 2014. Patients undergoing non-instrumented spine surgery (NSS) received single-dose prophylaxis throughout both periods. The outcome measure was the incidence of SSI. FINDINGS: For ISS, the SSI incidences were 5.3% for the single-dose protocol and 2.2% for the 72 h protocol (P < 0.01). For NSS, the SSI incidence was 0.8% between 2003 and 2008 and 1.2% between 2009 and 2014 (P = 0.054). Multiple correspondence analysis showed that in surgeries with an implant a one-dose prophylaxis carries a 7.1% risk of SSI; patients who received 72 h prophylaxis had a lower (3.6%) risk of SSI. CONCLUSION: Analysis of individual categories of data suggests that 72 h prophylaxis was the most important factor for minimizing the risk of wound infection in our study group.

Assessment of two gait training models: conventional physical therapy and treadmill exercise, in terms of their effectiveness after stroke.

BACKGROUND: Rehabilitation provided to patients after stroke mainly aims at improvement in gait function. The most common gait training strategies include treadmill exercise and traditional overground gait training. The study was designed to assess the effectiveness of two models of gait re-education in post-stroke patients, namely conventional physical therapy and treadmill training. METHODS: A systematic literature review was performed, taking into account the online databases of Medline (PubMed), Science Direct, Web of Science, Google Scholar, and clinical trials registries. The following inclusion criteria were applied: studies published from 2008 to 2018, written in English, involving treatment and control groups, investigating conventional physical therapy and treadmill training administered for gait re-education after stroke. RESULTS: Out of 160 articles identified, 23 met the inclusion criteria and were reviewed and analyzed. One hundred fifteen projects involving clinical trials were identified; out of these nine reports from the last five years are included in the review. The number of participants in all the studies totaled at 1,772. The participants in all the studies represented both sexes, and their age ranged from 18 to the late 80s, with an average of 60+ years of age. In most cases, the patients examined were at a chronic stage post-stroke, i.e., more than six months following stroke onset. The most frequently applied types of treadmill training included: high-intensity aerobic treadmill training and treadmill training with or without body weight support. Most interventions involved participation in 30- or 60-minute sessions, from three to five times weekly, for the duration of six to 16 weeks. CONCLUSIONS: Treadmill training seems to be a valuable and effective method of gait re-education, which can be used at various periods following a stroke, and mainly leads to improvement in walking speed and walking capacity. However, no standard has been defined so far with regard to treadmill-supported recovery of gait function in patients after stroke. We still do not know the optimum duration and frequency of exercise. Further study should investigate long-term effects and the way treadmill training impacts on patients' daily activities. HIPPOKRATIA 2018, 22(2): 51-59.