ABSTRACT
Energy released from beta emission causes molecules that incorporate tritium (3 H) and carbon-14 (14 C) atoms to be less stable than their stable labeled counterparts, thus making radiolabeled compounds prone to self-radiolysis. This literature review examines the stability of organic compounds incorporating 3 H and 14 C atoms and discusses stability of the compound with respect to functional groups within the radiolabeled molecules. The goal of this paper is to serve as a reference for the stability of radiolabeled compounds.
Subject(s)
Carbon RadioisotopesABSTRACT
Radiolabeled compounds are invaluable tools used to study synthetic and biological processes. Radiolabeled polymers find uses in mechanistic pathway elucidation, bioincorporation studies, biodegradation studies, and drug delivery applications. This literature review examines the syntheses (or biosyntheses), physical properties, and applications of radiolabeled polymers which contain covalently bound tritium and carbon-14 atoms.