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1.
Valvular heart disease associated with fenfluramine-phentermine.
Wolff, F W.
N Engl J Med ; 337(24): 1774; author reply 1775-6, 1997 Dec 11.
Article in English | MEDLINE | ID: mdl-9411250

Subject(s)
Appetite Depressants/adverse effects , Fenfluramine/adverse effects , Heart Valve Diseases/chemically induced , Phentermine/adverse effects , Animals , Drug Evaluation, Preclinical , Humans , United States , United States Food and Drug Administration
2.
Fraud in medical science.
Wolff, F W.
Lancet ; 346(8971): 378, 1995 Aug 05.
Article in English | MEDLINE | ID: mdl-7677905

Subject(s)
Research/standards , Scientific Misconduct
3.
Drug toxicity findings and no action taken.
Wolff, F W.
Arch Toxicol Suppl ; 17: 346-8, 1995.
Article in English | MEDLINE | ID: mdl-7786171

Subject(s)
Drug-Related Side Effects and Adverse Reactions , Animals , History, 17th Century , History, 18th Century , History, 19th Century , Humans , Legislation, Drug/history , Pharmaceutical Preparations/history
4.
Cardiotoxicity studies with diazoxide, reserpine, guanethidine, and combinations of diazoxide and propranolol in dogs.
Balazs, T; Herman, E H; Earl, F L; Wolff, F W.
Toxicol Appl Pharmacol ; 33(3): 498-504, 1975 Sep.
Article in English | MEDLINE | ID: mdl-1188947

Subject(s)
Diazoxide/toxicity , Guanethidine/toxicity , Heart/drug effects , Propranolol/toxicity , Reserpine/toxicity , Animals , Blood Pressure/drug effects , Dogs , Drug Combinations , Electrocardiography , Female , Heart Rate/drug effects , Hydralazine/pharmacology , Male , Myocardium/pathology , Time Factors
5.
Drug failure in reducing pressor effect of isometric handgrip stress test in hypertension.
Lamid, S; Wolff, F W.
Am Heart J ; 86(2): 211-5, 1973 Aug.
Article in English | MEDLINE | ID: mdl-4719942

Subject(s)
Antihypertensive Agents/pharmacology , Blood Pressure/drug effects , Hand , Muscle Contraction , Stress, Physiological , Adult , Aged , Antihypertensive Agents/therapeutic use , Blood Pressure Determination , Electrocardiography , Female , Guanethidine/therapeutic use , Humans , Hydralazine/therapeutic use , Hydrochlorothiazide/therapeutic use , Hypertension/drug therapy , Male , Middle Aged , Pilot Projects , Reserpine/therapeutic use
6.
Some hypotensive thiadiazoles.
Grant, A M; Krees, S V; Mauger, A B; Rzeszotarski, W J; Wolff, F W.
J Med Chem ; 15(10): 1082-4, 1972 Oct.
Article in English | MEDLINE | ID: mdl-5069782

Subject(s)
Antihypertensive Agents/chemical synthesis , Thiadiazoles/chemical synthesis , Administration, Oral , Animals , Antihypertensive Agents/administration & dosage , Antihypertensive Agents/pharmacology , Blood Glucose/analysis , Blood Pressure/drug effects , Diuresis/drug effects , Male , Rats , Structure-Activity Relationship , Thiadiazoles/administration & dosage , Thiadiazoles/pharmacology
7.
Insulin secretion studied in the perfused rat pancreas. II. Effect of glucose, glucagon, 3'5' adenosine monophosphate, theophylline, imidazole and phenoxybenzamine; their interaction with diazoxide.
Basabe, J C; Lopez, N L; Viktora, J K; Wolff, F W.
Diabetes ; 20(7): 457-66, 1971 Jul.
Article in English | MEDLINE | ID: mdl-4397560

Subject(s)
Adenine Nucleotides/pharmacology , Diazoxide/pharmacology , Glucagon/pharmacology , Glucose/pharmacology , Imidazoles/pharmacology , Insulin/metabolism , Pancreas/metabolism , Phenoxybenzamine/pharmacology , Theophylline/pharmacology , Adrenergic alpha-Antagonists/pharmacology , Animals , Buffers , Cyclic AMP/analysis , Cyclic AMP/antagonists & inhibitors , Cyclic AMP/pharmacology , Diazoxide/analysis , Diazoxide/antagonists & inhibitors , Glucagon/analysis , Glucagon/antagonists & inhibitors , Glucose/analysis , Glucose/antagonists & inhibitors , Imidazoles/analysis , Imidazoles/antagonists & inhibitors , Insulin Secretion , Male , Pancreas/drug effects , Perfusion , Phenoxybenzamine/analysis , Phenoxybenzamine/antagonists & inhibitors , Radioimmunoassay , Rats , Stimulation, Chemical , Theophylline/analysis , Theophylline/antagonists & inhibitors
8.
Insulin secretion studied in the perfused rat pancreas. I. Effect of tolbutamide, leucine and arginine; their interaction with diazoxide, and relation to glucose.
Basabe, J C; Lopez, N L; Viktora, J K; Wolff, F W.
Diabetes ; 20(7): 449-56, 1971 Jul.
Article in English | MEDLINE | ID: mdl-5556282

Subject(s)
Arginine/pharmacology , Diazoxide/pharmacology , Glucose/pharmacology , Insulin/metabolism , Leucine/pharmacology , Pancreas/metabolism , Tolbutamide/pharmacology , Animals , Arginine/analysis , Arginine/antagonists & inhibitors , Buffers , Diazoxide/analysis , Diazoxide/antagonists & inhibitors , Glucose/analysis , Glucose/antagonists & inhibitors , Insulin Secretion , Leucine/analysis , Leucine/antagonists & inhibitors , Male , Pancreas/analysis , Pancreas/drug effects , Perfusion , Radioimmunoassay , Rats , Stimulation, Chemical , Tolbutamide/analysis , Tolbutamide/antagonists & inhibitors
9.
The effect of tolbutamide on blood pressure.
Wales, J K; Grant, A M; Wolff, F W.
J Pharmacol Exp Ther ; 178(1): 130-40, 1971 Jul.
Article in English | MEDLINE | ID: mdl-4325857

Subject(s)
Blood Pressure/drug effects , Tolbutamide/pharmacology , Angiotensin II/pharmacology , Animals , Blood Glucose , Diazoxide/pharmacology , Diuresis , Dogs , Hydralazine/pharmacology , Insulin/blood , Norepinephrine/pharmacology , Pentolinium Tartrate/pharmacology , Phentolamine/pharmacology
10.
Mode of action of a diazoxide analog (A025). Its effects on insulin secretion.
Grant, A M; Basabe, J C; Lopez, N L; Krees, S V; Wolff, F W.
Diabetes ; 19(9): 630-8, 1970 Sep.
Article in English | MEDLINE | ID: mdl-4990295

Subject(s)
Blood Glucose , Diazoxide , Hyperglycemia/chemically induced , Insulin/metabolism , Pancreas/drug effects , Adrenal Glands/physiology , Animals , Autoanalysis , Blood Pressure/drug effects , Blood Urea Nitrogen , Catecholamines/metabolism , Diazoxide/administration & dosage , Diazoxide/pharmacology , Dogs , Female , Glucose Tolerance Test , Haplorhini , Hyperglycemia/metabolism , Hypoglycemic Agents , Insulin/blood , Insulin Secretion , Liver Glycogen , Male , Mice , Rats , Time Factors , Tolbutamide/pharmacology
11.
Preliminary clinical evaluation of glybenclamide in treatment of diabetes mellitus.
Johnson, B F; Bhatia, C K; Rzeszotarski, W J; Wolff, F W.
Diabetes ; 19(8): 579-84, 1970 Aug.
Article in English | MEDLINE | ID: mdl-4915447

Subject(s)
Diabetes Mellitus/drug therapy , Hypoglycemic Agents/therapeutic use , Alkaline Phosphatase/analysis , Bilirubin/urine , Blood Cell Count , Blood Glucose , Blood Sedimentation , Blood Urea Nitrogen , Chlorpropamide/pharmacology , Clinical Trials as Topic , Creatinine/urine , Female , Humans , Hypoglycemia/chemically induced , Hypoglycemic Agents/administration & dosage , Hypoglycemic Agents/adverse effects , Insulin/blood , Male , Prothrombin Time , Transaminases/metabolism , Triglycerides/urine
12.
Trial of mannoheptulose in man.
Johnson, B F; Wolff, F W.
Metabolism ; 19(5): 354-62, 1970 May.
Article in English | MEDLINE | ID: mdl-4315222

Subject(s)
Heptoses/pharmacology , Adenoma, Islet Cell/drug therapy , Clinical Trials as Topic , Diarrhea/chemically induced , Glucose/metabolism , Heptoses/toxicity , Heptoses/urine , Humans , Hypoglycemia/chemically induced , Insulin/metabolism , Insulin Secretion , Nausea/chemically induced , Placebos
13.
Treatment of scopolamine-induced delirium.
Ullman, K C; Groh, R H; Wolff, F W.
Lancet ; 1(7640): 252, 1970 Jan 31.
Article in English | MEDLINE | ID: mdl-4189068

Subject(s)
Delirium/drug therapy , Physostigmine/therapeutic use , Scopolamine/adverse effects , Delirium/chemically induced , Female , Humans , Suicide
14.
A rat pancreas-small gut preparation for the study of intestinal factor(s) and insulin release.
Penhos, J C; Wu, C H; Basabe, J C; Lopez, N; Wolff, F W.
Diabetes ; 18(11): 733-8, 1969 Nov.
Article in English | MEDLINE | ID: mdl-5348516

Subject(s)
Insulin/metabolism , Intestine, Small/metabolism , Pancreas/metabolism , Animals , Buffers , Gastrointestinal Hormones/metabolism , Glucagon/metabolism , Glucose/analysis , Glucose/pharmacology , Insulin/analysis , Insulin Secretion , Methods , Perfusion , Rats
15.
The effect of diazoxide on glucose disappearance in eviscerated dogs.
Staquet, M J; Wales, J K; Bradley, P B; Wolff, F W.
Arch Int Pharmacodyn Ther ; 179(1): 36-9, 1969 May.
Article in English | MEDLINE | ID: mdl-5348397

Subject(s)
Blood Glucose/metabolism , Diazoxide/pharmacology , Animals , Dogs , Female , Infusions, Parenteral , Intestines/physiology , Intestines/surgery , Liver/physiology , Liver/surgery , Omentum/physiology , Omentum/surgery , Pancreas/physiology , Pancreas/surgery , Spleen/physiology , Spleen/surgery , Stomach/physiology , Stomach/surgery , Time Factors
16.
Effect of ingested mannoheptulose in animals and man.
Viktora, J K; Johnson, B F; Penhos, J C; Rosenberg, C A; Wolff, F W.
Metabolism ; 18(2): 87-102, 1969 Feb.
Article in English | MEDLINE | ID: mdl-4974849

Subject(s)
Heptoses/pharmacology , Adult , Animals , Blood Glucose , Dogs , Female , Haplorhini , Heptoses/analysis , Heptoses/blood , Heptoses/therapeutic use , Heptoses/urine , Humans , Hyperinsulinism/drug therapy , Hypoglycemia/drug therapy , Insulin/blood , Intestinal Absorption , Male , Middle Aged , Plants/analysis , Rats
17.
Structure-activity relationships of benzothiadiazine compounds as hyperglycemic agents.
Wales, J K; Krees, S V; Grant, A M; Viktora, J K; Wolff, F W.
J Pharmacol Exp Ther ; 164(2): 421-32, 1968 Dec.
Article in English | MEDLINE | ID: mdl-5699103

Subject(s)
Benzothiadiazines/pharmacology , Hyperglycemia/chemically induced , Animals , Benzothiadiazines/chemical synthesis , Blood Glucose , Chemistry, Pharmaceutical , Injections, Intraperitoneal , Rats , Urination/drug effects
18.
Structure activity of diuretics as hyperglycaemic agents.
Grant, A M; Krees, S; Viktora, J K; Wales, J K; Wolff, F W.
Br J Pharmacol ; 34(3): 676P-677P, 1968 Nov.
Article in English | MEDLINE | ID: mdl-4973221

Subject(s)
Diuretics/pharmacology , Hyperglycemia/chemically induced , Animals , Chlorthalidone/pharmacology , Drug Antagonism , Haplorhini
19.
Some effects of hydralazine on hypertensive patients with impaired kidney function.
Spechtmeyer, H; Krees, S V; Wolff, F W.
Med Ann Dist Columbia ; 37(10): 526-9, 1968 Oct.
Article in English | MEDLINE | ID: mdl-5245486

Subject(s)
Kidney/drug effects , Animals , Glomerular Filtration Rate , Humans , Hydralazine/adverse effects , Hydralazine/therapeutic use , Hypertension/drug therapy , Injections, Intravenous , Kidney Diseases/complications , Rats
20.
Clinical studies in the use of oral diazoxide in postsurgical and functional hypoglycemia.
Wales, J K; Spechtmeyer, H; Viktora, J K; Wolff, F W.
Med Ann Dist Columbia ; 37(9): 460-8, 1968 Sep.
Article in English | MEDLINE | ID: mdl-5248391

Subject(s)
Diazoxide/therapeutic use , Hypoglycemia/drug therapy , 17-Hydroxycorticosteroids/urine , 17-Ketosteroids/urine , Adolescent , Adult , Blood Glucose , Catecholamines/urine , Female , Glucose Tolerance Test , Humans , Insulin/blood , Kidney Function Tests , Male , Postgastrectomy Syndromes
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