Draf's endonasal drainage for inflammatory frontal sinus disease / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#To introduce endonasal drainage procedures to frontal sinus in inflammatory sinus disease and its indications, methods and efficacy.@*METHOD@#One hundred thirty two patients undergoing Draf I-III frontal sinus drainage procedures with 1-12 years follow-up were reviewed retrospectively.@*RESULT@#Forty two patients underwent type I frontal sinusotomy, 43 type II sinusotomy and 47 type III sinusotomy. A successful result was seen in these groups, 83.4%, 83.7%, and 89.4% respectively. Best effect was gained by type III sinusotomy. There was no significant difference in efficacy between the different Draf frontal sinus drainage procedures (P > 0.05).@*CONCLUSION@#Endonasal microscopic-endoscopic frontal drainage treatment of refractory, polypoid and recurrent frontal sinusitis can yield successful results.

Cytogenetic aberrations of esthesioneuroblastoma studied by comparative genomic hybridization / 中华肿瘤杂志

<p><b>OBJECTIVE</b>To characterize the cytogenetic alterations of esthesioneuroblastoma (ENB).</p><p><b>METHODS</b>Comparative genomic hybridization (CGH) was performed on genomic DNA extracted from 12 patients with primary ENB, 4 patients with tumor recurrence and 7 with metastasis. Equal amounts of biotin-labeled tumor DNA and digoxigenin-labeled normal reference DNA were hybridized to normal meta phase chromosomes. Tumor DNA was visualized by fluorescein (FITC) and normal DNA by rhodamin (TRITC ) and detected by fluorescence microscopy. The signal intensities of the different fluorochromes were quantitated as gray levels along the single chromosomes. The over-and under-represented DNA segments were determined by computation of FITC/TRITC ratio images and average ratio profiles.</p><p><b>RESULTS</b>Consensus deletion regions were most frequently observed on chromosomes 1p, 2q, 3p/q, 4p/q, 5p/q, 6q, 8p/q, 9p, 10p/q, 11p, 12q, 13q, 18q, and 21q. DNA over-representations were identified on chromosomes 1p, 7q, 9q, 11q, 14q, 16p/q, 17p/q, 19p/q, 20p/q and 22p/q. The genetic pattern of ENB was distinct from that of other small round-cell tumor types and neuroblastomas. The deletion on chromosome band 1p21-p31 was associated with bad prognosis. In particular, all patients died whose tumors had combined 1p21-p31 deletion, with tumors in clinical stage C or D, and of low differentiation (grade III or IV). Clonality analysis revealed a high concordance between pairs of primaries and metastases.</p><p><b>CONCLUSION</b>CGH analysis identifies characteristic cytogenetic aberrations of esthesioneuroblastoma associated with its malignant phenotype.</p>