[Growth dynamics of breast cancer. Comparison of cytohistologic parameters of the primary tumor, lymph node metastases and recurrent tumors]. / Untersuchungen zur Wachstumsdynamik des Mammakarzinoms. Vergleich zyto-histologischer Parameter bei Primärtumor, Lymphknotenmetastasen und Rezidivtumoren.

The dynamic of tumor growth has been estimated in breast cancer using cytologic and histologic criteria. There were definite differences between primary tumors with simultaneously observed metastases and tumors which had metastasized within the first two years following primary treatment. The primary tumors of the recurrent diseases were receptor positive more seldom, and they had a significant lower receptor concentration. Morphologically they were composed of larger cells with polymorphism and more mitoses. Between primary tumors and metastases there were no significant differences. We suspect the grade of malignancy is a typical attribute of a tumor not changing after having metastasized or recidivation. Changing tumor growth is caused by other reasons like general resistance.

Volume, staging and grading of gastro-intestinal carcinoma--a population-based study.

All cases of the Regional Cancer Registry, North Baden who developed a gastro-intestinal cancer during the period 1975-1980 were re-examined according to the following parameters: tumor volume, pT stage, pN stage, grading. In the period considered, 8424 cases out of 14,061 cases with histologically proven gastrointestinal cancer could be grouped according to the pT stage. Most of the cases were operated at the pT2 or pT3 stage. Remarkable differences in the different tumor localizations were obtained. Stomach carcinoma had the highest percentage of the pT4 stage (36.2%), rectum carcinoma the lowest (7%). In all primaries a close coherence of tumor volume and pT stage was noted. Carcinoma at the pT1 stage measured 20 cm3 on average, those at the pT4 stage 170 cm3. No coherence of staging and age of the patients could be obtained. Younger patients showed a higher percentage of undifferentiated carcinoma than older patients. Survival data could not be obtained due to the data protection law.

[Correlation of estrogen receptors and histologic and cytologic grading of breast cancer]. / Die Beziehungen zwischen den Ostrogenrezeptoren und dem histologischen und zytologischen Grading beim Mammakarzinom.

Correlations between estrogen receptors and other prognostic criteria have been examined. These criteria are clinical extent, status of lymph nodes, histologic differentiation, histologic and cytologic grading. Cancers with a good prognosis are much more receptor positive than those with a bad prognosis. The quantity of receptors does not allow any prognostic statement. Possible reasons for it are discussed.