Oral Potentially Malignant Disorders.

Oral potentially malignant disorders (OPMDs) are precursor lesions that may undergo malignant transformation to oral cancer. These lesions most commonly present clinically as white patches (leukoplakia). However, they may also be red (erythroplakia), or red and white (erythroleukoplakia). There are many risk factors associated with the development of an OPMD, and with the risk of malignant transformation of the lesion. A biopsy with subsequent microscopic examination from the lesional tissue is necessary in identification of OPMD. This article reviews the clinical appearance of OPMDs, associated risk factors, diagnosis and histologic appearance, and treatment.

Treatment of a rare ganglioneuroma with resection and reconstruction of the mandible: a case report and literature review.

Ganglioneuromas are rare neuroblastic tumors that develop from the neural crests of the sympathetic nervous system. Because ganglioneuromas of the mandible have been infrequent, they do not have a standardized management protocol. As of 2000, only 5 cases had been reported. Ganglioneuromas are unique tumors that can undergo histologic maturation from a malignancy to a benign variant. We present the case of a 15-year-old boy with a ganglioneuroma of the mandible and the results of surgical management, including immediate reconstruction with a free fibula microvascular flap.