Subject(s)
Lipids/blood , Pre-Eclampsia/blood , Pregnancy , Dietary Fats/administration & dosage , Female , HumansABSTRACT
The influence of intraventricular injection of 50 microng of noradrenaline (NA) on behavior of female Wistar rats in various phases of the sexual cycle, and the influence of 17-beta-estradiol and progesterone in castrated female rats were studied. Changes in motor and exploratory activity were observed in the course of the sexual cycle in female rats. Sensitivity to NA injected intraventricular varied significantly in different phases of the sexual cycle. Castration depressed the action of NA on motor and exploratory activities in rats, and progesterone prevented the depressive effect of NA in castrated rats.
Subject(s)
Behavior, Animal/drug effects , Estrus/drug effects , Norepinephrine/pharmacology , Animals , Castration , Cerebral Ventricles , Diestrus/drug effects , Estradiol/pharmacology , Exploratory Behavior/drug effects , Female , Injections, Spinal , Motor Activity/drug effects , Norepinephrine/administration & dosage , Pregnancy , Proestrus/drug effects , Progesterone/pharmacology , RatsABSTRACT
In male Wistar rats PGF2alpha or PGE1 were injected intracerebroventricularly (icv) in a dose of 1 or 10 mug. Immediately or 1 hr after injection the locomotor and exploratory activity were measured. The levels of noradrenaline (NA), dopamine (DA) 5-hydroxytryptamine (5-HT), 5-hydroxyindoleacetic acid (5-HIAA) and acetylcholine (Ach) were measured in discrete brain areas. Both PGs applied ivc caused the depression of locomotor and exploratory activity in rats. PGE1 acted longer. Both substances but PGE1 more intensively affected the level of estimated biogenic amines in different brain structures. It is concluded that PGF2alpha and E1 are central nervous depressants. Both PGs affect neurons producing NA or 5-HT or Ach in discrete areas of brain in different manner. There is different susceptibility of brain structures on PGs action.
