Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 3 de 3
Filter
Add more filters










Database
Language
Publication year range
1.
Vet Radiol Ultrasound ; 65(3): 303-307, 2024 May.
Article in English | MEDLINE | ID: mdl-38513150

ABSTRACT

A potbelly pig was evaluated for anorexia and icterus. Clinicopathologic abnormalities suggested an active inflammatory hepatobiliary process. Ultrasound and CT of the abdomen revealed an extrahepatic biliary obstruction of the common bile duct (CBD). Surgical exploration and choledochotomy revealed a markedly dilated CBD containing a large volume of intraluminal inspissated biliary material. This case report describes the imaging findings of an extrahepatic biliary obstruction secondary to abscessation within the CBD in a pig.


Subject(s)
Cholestasis, Extrahepatic , Swine Diseases , Tomography, X-Ray Computed , Animals , Swine , Tomography, X-Ray Computed/veterinary , Cholestasis, Extrahepatic/veterinary , Cholestasis, Extrahepatic/diagnostic imaging , Cholestasis, Extrahepatic/etiology , Swine Diseases/diagnostic imaging , Swine Diseases/diagnosis , Abscess/veterinary , Abscess/diagnostic imaging , Common Bile Duct Diseases/veterinary , Common Bile Duct Diseases/diagnostic imaging , Bile Ducts, Extrahepatic/diagnostic imaging , Male , Common Bile Duct/diagnostic imaging , Common Bile Duct/pathology , Female
2.
Cells ; 12(7)2023 04 05.
Article in English | MEDLINE | ID: mdl-37048164

ABSTRACT

Asthma is characterized by chronic lower airway inflammation that results in airway remodeling, which can lead to a permanent decrease in lung function. The pathophysiology driving the development of asthma is complex and heterogenous. Animal models have been and continue to be essential for the discovery of molecular pathways driving the pathophysiology of asthma and novel therapeutic approaches. Animal models of asthma may be induced or naturally occurring. Species used to study asthma include mouse, rat, guinea pig, cat, dog, sheep, horse, and nonhuman primate. Some of the aspects to consider when evaluating any of these asthma models are cost, labor, reagent availability, regulatory burden, relevance to natural disease in humans, type of lower airway inflammation, biological samples available for testing, and ultimately whether the model can answer the research question(s). This review aims to discuss the animal models most available for asthma investigation, with an emphasis on describing the inciting antigen/allergen, inflammatory response induced, and its translation to human asthma.


Subject(s)
Asthma , Humans , Mice , Rats , Animals , Guinea Pigs , Sheep , Horses , Dogs , Disease Models, Animal , Asthma/drug therapy , Proteins , Inflammation
3.
Front Vet Sci ; 9: 997139, 2022.
Article in English | MEDLINE | ID: mdl-36713876

ABSTRACT

Equine asthma is a naturally occurring lung disease characterized by chronic, partially reversible airway obstruction, pulmonary remodeling, and lower airway inflammation. Asthma is currently divided into two major groups, mild to moderate asthma (mEA) and severe asthma (sEA), but further subtyping by phenotype (i.e., clinical presentation) and/or endotype (i.e., cellular mechanisms) may be warranted. For this study, we were interested in further investigation of cellular and inflammatory characteristics of EA, including airway mast cells. The purpose of this study was to: (1) compare mast cell protease mRNA expression between healthy and asthmatic horses, (2) analyze the cytokine profile present in BALF of currently defined equine asthma groups, and (3) use these data to evaluate potential biomarkers of defined asthma groups. We hypothesized that there would be significant differences in the cellular mast cell phenotypes (i.e., mucosal vs. connective tissue) and cytokine profiles in the BALF of asthmatic vs. healthy horses and across asthma groups. We assert these characteristics may inform additional subtypes of equine asthma. Adult horses were recruited from the institution's teaching herd and clinical caseload. Mast cell protease gene expression of the BALF cellular component and multiplex bead immunoassay for cytokine concentrations in the BALF supernatant were investigated. Airway mast cells primarily expressed tryptase, with low levels of chymase. No significant changes in protease expression were detected across groups. Horses with severe asthma had increased TNF-α, CXCL-8, and IFN-γ concentrations in BALF supernatant. Multidimensional analysis demonstrated healthy and mEA horses have overlapping characteristics, with sEA separating from the other groups. This difference was primarily due to BALF neutrophil and lymphocyte concentrations. These study results further inform understanding of EA immunopathology, and future studies designed to investigate asthma phenotypes and endotypes. Ultimately, a better understanding of these groups could help identify novel therapeutic strategies.

SELECTION OF CITATIONS
SEARCH DETAIL
...